Hepatocellular carcinoma(HCC)is a common and lethal malignant tumor.Recently,the role of the gut microbiota-mediated gut-liver axis in HCC has attracted widespread attention.Gut microbiota dysbiosis could reportedly promote HCC onset and progression through mechanisms such as inflammatory response induction,immune reaction regulation,and metabolic reprogramming.Specific alte-rations in gut microbiota composition demonstrate a potential diagnostic value for early HCC screening.Furthermore,gut microbiota can significantly influence postoperative recovery and comprehensive treatment responses in patients with HCC,suggesting that the gut micro-biota could serve as a potential target for HCC therapy.Currently,interventional strategies such as dietary adjustments,probiotics/prebio-tics,and fecal microbiota transplantation show promise for improving the gut-liver microenvironment,enhancing treatment sensitivity,and delaying disease progression.In this review,we systematically elaborate on recent research advances concerning the role of gut microbiota in HCC pathogenesis,early diagnosis,and therapeutic intervention,aiming to provide a theoretical basis and novel strategies for the com-prehensive HCC prevention and management.

Hepatocellular carcinoma(HCC)is a common and lethal malignant tumor.Recently,the role of the gut microbiota-mediated gut-liver axis in HCC has attracted widespread attention.Gut microbiota dysbiosis could reportedly promote HCC onset and progression through mechanisms such as inflammatory response induction,immune reaction regulation,and metabolic reprogramming.Specific alte-rations in gut microbiota composition demonstrate a potential diagnostic value for early HCC screening.Furthermore,gut microbiota can significantly influence postoperative recovery and comprehensive treatment responses in patients with HCC,suggesting that the gut micro-biota could serve as a potential target for HCC therapy.Currently,interventional strategies such as dietary adjustments,probiotics/prebio-tics,and fecal microbiota transplantation show promise for improving the gut-liver microenvironment,enhancing treatment sensitivity,and delaying disease progression.In this review,we systematically elaborate on recent research advances concerning the role of gut microbiota in HCC pathogenesis,early diagnosis,and therapeutic intervention,aiming to provide a theoretical basis and novel strategies for the com-prehensive HCC prevention and management.

Objective: To analyze the application of digital games for interventions to reduce risky sexual behavior among adolescents, so as to provide a reference for reducing adolescent risky sexual behavior. Methods: The study used PubMed, Web of Science, Cochrane Library, Scopus, Embase, China Biomedical Database, CNKI, Wanfang Database and VIP to carry out a literature search of the application of digital games for interventions aimed at reducing risky sexual behavior among adolescents covering the time period up until February 2024. Results: A total of 10 English articles were included, involving a total of 3 063 adolescents aged 10-24 years old. The publication time spanned from 2013 to 2023. The development and design of the digital games were mostly based on cognitive behavior theory and authentic decision making situations and dialogues. The game participants were divided into single party and multi party categories, mainly using virtual role playing, interactive narrative, and adventure challenges, and there were some differences in content. Digital game intervention had good feasibility and acceptability, which could improve adolescents sexual health knowledge, attitudes, self efficacy, and risk perception, so as to reduce the occurrence of risky behavior. Conclusion As an intervention aimed at reducing risky sexual behavior in adolescents, digital show has significant advantages and can serve as a new prevention and control strategy.