EFFECT OF SUBGINGIVAL IRRIGATION WITH SILVER NANOCOLLOID ON CLINICAL PERIODONTAL PARAMETERS AS AN ADJUNCT TO SUBGINGIVAL ROOT DEBRIDEMENT: A RANDOMIZED, SPLIT MOUTH CONTROLLED TRIAL Local delivery of antimicrobials has been investigated as an adjunct to conventional therapy. This study aimed to determine the efficacy and clinical outcomes of nanocolloid silver irrigation as an adjunct to mechanical root debridement in the management of periodontitis. Fifty one (51) patients with the presence of at least 1 pocketing site of ≥ 6mm in both contralateral half mouth after periodontal assessment were enrolled. In this split mouth design study, pocketing sites of ≥ 6mm were treated with root surface instrumentation in combination with either Perioflush or saline subgingival irrigation. Bleeding score showed a significant reduction over the observation period in control group (p = 0.034). The probing pocket depths were reduced for both groups, with a significant treatment effect (p < 0.001) from baseline to 6-week review. Also, there was a notable reduction in overall median pocket depth in both genders. In conclusion, within the limitations of the study, no additional benefits were observed with the use of nanocolloid silver irrigation following mechanical debridement.