Objective:To study the impact of hyperbaric oxygen (HBO) therapy on emotion and cognitive disorders in patients with Parkinson’s disease (PD).Methods:A total of 60 patients diagnosed as PD in the Department of Neurology of Guangzhou Xinhai Hospital from July 2014 to July 2019 were selected as study objects and given HBO therapy on the basis of conventional medication. The Hamilton anxiety rating scale (HAMA), the Hamilton depression rating scale (HAMD), the unified Parkinson’s disease rating scale (UPDRS), and P300 wave were used before and after 4 courses of HBO treatment to measure the changes of patients’ medical conditions, so as to evaluate the effects of HBO on emotion, mental behavior, motor and cognitive functions of PD patients.Results:Compared with those before the 4 courses of HBO treatment, the incidences of anxiety, depression, and cognitive disorder in 60 patients dropped significantly; the HAMA and HAMD scores were significantly decreased; the incubation period of P300 wave was significantly reduced, while its amplitude was significantly increased ( P<0.05); the total UPDRS score, and the scores of UPDRSⅠ, UPDRSⅡ and UPDRSⅢ were all significantly decreased ( P<0.05); the daily levodopa equivalent dosage (DLED) was significantly reduced ( P<0.05) and the Hoehn and Yahr scale improved when the medication was "off" ( P<0.05). Conclusion:HBO therapy can effectively relieve the emotional and cognitive disorders and other non-motor symptoms in PD patients by reducing the incidence of their depression and anxiety, so as to contain the PD condition, lessen the severity of cognitive dysfunction, hence improving their activity of daily living.

Objective:To study the impact of hyperbaric oxygen (HBO) therapy on emotion and cognitive disorders in patients with Parkinson’s disease (PD).Methods:A total of 60 patients diagnosed as PD in the Department of Neurology of Guangzhou Xinhai Hospital from July 2014 to July 2019 were selected as study objects and given HBO therapy on the basis of conventional medication. The Hamilton anxiety rating scale (HAMA), the Hamilton depression rating scale (HAMD), the unified Parkinson’s disease rating scale (UPDRS), and P300 wave were used before and after 4 courses of HBO treatment to measure the changes of patients’ medical conditions, so as to evaluate the effects of HBO on emotion, mental behavior, motor and cognitive functions of PD patients.Results:Compared with those before the 4 courses of HBO treatment, the incidences of anxiety, depression, and cognitive disorder in 60 patients dropped significantly; the HAMA and HAMD scores were significantly decreased; the incubation period of P300 wave was significantly reduced, while its amplitude was significantly increased ( P<0.05); the total UPDRS score, and the scores of UPDRSⅠ, UPDRSⅡ and UPDRSⅢ were all significantly decreased ( P<0.05); the daily levodopa equivalent dosage (DLED) was significantly reduced ( P<0.05) and the Hoehn and Yahr scale improved when the medication was "off" ( P<0.05). Conclusion:HBO therapy can effectively relieve the emotional and cognitive disorders and other non-motor symptoms in PD patients by reducing the incidence of their depression and anxiety, so as to contain the PD condition, lessen the severity of cognitive dysfunction, hence improving their activity of daily living.