Objective To explore the effect and complications of CT-guided radiofrequency thermocoagulation(RFTC)through foramen ovale approach in the treatment of maxillary neuralgia of cranial nerve V(CNV).Methods A total of 100 patients with maxillary neuralgia of CNV were retrospectively selected.According to different treatment method,they were divided into A group(48 cases,CT-guided RFTC through foramen ovale approach)and B group(52 cases,RFTC through maxillary nerve of pterygopalatine fossa approach).The imaging findings of CT-guided RFTC through foramen ovale approach were observed.The hospitalization time and operation time,visual analogue scale(VAS)scores and patients satisfaction score(PSS)before and after surgery,as well as occurrence of complications during RFTC were compared between the two groups.Results There were no significant differences in hospitalization and operation time between the two groups(P＞0.05).At 1 d and 1 month after surgery,VAS scores in A group were lower than those in B group(P＜0.05).At 1 month after surgery,PSS in A group was higher than that in B group(P＜0.05).During RFTC,there was no significant difference in incidence of complications between the two groups(P＞0.05).Conclusion CT-guided RFTC through foramen ovale approach is comparable to RFTC through maxillary nerve of pterygopalatine fossa approach in terms of operation time,hospitalization time and incidence of complications in patients with maxillary neuralgia of CNV.The former can alleviate maxillary neuralgia of CNV and improve patients satisfaction.

Objective: To explore the survival difference of patients with colon and rectal neuroendocrine neoplasm (NEN) at different stages. Methods: We identified 8 679 patients with colorectal NEN diagnosed between 1988 and 2014 from the Surveillance, Epidemiology, and End Results (SEER) registry, including 5 437 rectal NEN and 3 242 colon NEN ( 1 681 cecum NEN ). Survival curve was drawn by Kaplan-Meier method. Prognostic factors were analyzed by univariate analysis and multivariate Cox regression model. Results: The ratio of male patients with colon and rectal NEN was similar to female (P=0.095). Rectal NEN patients were younger (P<0.001), more highly differentiated (P<0.001), and with earlier stage (P<0.001). Survival analysis showed that the survival of rectal NEN was superior to that of colon NEN, with 10-year tumor-specific survival rates of 86.8% and 44.8% respectively (P<0.001). Multivariate Cox analysis showed that age, gender, marital status, primary tumor site, grade, stage and surgery were independent prognostic factors of colorectal NEN (all P<0.01). The most important factor was stage (HR=3.531), followed by differentiation grade (HR=1.856). Stratified analysis displayed that the survival of rectal NEN in stage Ⅰ, Ⅱ and Ⅳ were better than those of corresponding stage of colon NEN (all P<0.05), but worse in stage Ⅲ (P=0.012). While the survival of rectal NEN were significantly better than those of colon NEN within all stages after excluding 1681 cases of cecal NEN (all P<0.05). Among the patients with well-differentiated NEN, the survival of rectal NEN in stage Ⅰ, Ⅲ and Ⅳ were better than those of corresponding stage of colon NEN (all P<0.05) while there was no significant difference in stage Ⅱ(P=0.169). For poor-differentiated NEN, only the survival of rectal NEN patients in stage Ⅳ (P=0.001) was significant longer than those of colon NEN, while there was no significant difference in stage Ⅰ, Ⅱ and Ⅲ (stage Ⅰ: P=0.760; stage Ⅱ: P=0.181; stage Ⅲ: P=0.313). Conclusions The survival of NEN patients in colon and rectum is different. Cecum NEN should be considered as a separated tumor for prognostic analysis due to its special clinicopathologic characteristics.