Systemic lupus erythematosus(SLE)is a chronic autoimmune disease with complex etiology and diverse clinical manifestations.Its pathogenesis is complex,and the clinical treatment effect is not yet ide-al.Lipids are precursors of bioactive metabolites and components of cell membranes,exerting direct and indi-rect regulatory effects on signal transduction,gene regulation,and cell activation.Furthermore,lipids are one of the most significantly changing biomarkers in the serum of SLE patients.This article reviews the abnormal manifestations of lipid metabolism in SLE,the regulation of lipid metabolism and immune cell function,and possible therapeutic applications,providing new ideas for the diagnosis and treatment of SLE.

Objective To explore the relationship between the hepatic injury and the severity of the patients with non-gallstone severe acute pancreatitis,so as to provide some evidences in the treatment on the hepatic injury,to lower the systemic and local applications of SAP,as well as lower the morality of SAP.Methods Patients suffering from non-gallstone SAP were retrospectively analyzed.We statisticated the occurrence of multiple organ dysfunction syndrome.We adopted the occurrence of MODS of the patients as the indicatrix of prognosis and analyzed the results.Univariate analysis and multivariate logistic regression analysis were used to analyze the ralationship between the markers of heapatic injury and the prognosis of the patients suffered of non-gallstone SAP.Results The univariate logistic regression analysis of the relationship between hepatic dysfunction and the occur of MODS of non-gallstone SAP shows that there were correlation between the occur of MODS and AST,ALT,ALB,respectively.The multivariate logistic regression analysis shows that there were correlation between the occur of MODS and AST,ALT,ALB,respectively.Conclusion The study showed that the heighten of the serum consentration of AST,ALT,TB and the degrade of the serum consentration of Alb were the independent influencing factors of patients with non-gallstone SAP,respectively,and suggested the unfavourable prognosis of the patients.