A 78-year-old male was referred to our facility due to persistent fever and arthralgia. Transesophageal echocardiography revealed fragile vegetations measuring 26 mm in length attached to the mitral valve (MV), along with severe mitral regurgitation. Magnetic resonance imaging showed multiple cerebral infarctions. He also had an abscess at his left sternoclavicular joint caused by Streptococcus agalactiae, which was identical to the strain identified in his blood culture. He was diagnosed with active infective endocarditis due to Streptococcus agalactiae and severe mitral regurgitation. To prevent postoperative mediastinitis, which could be a complication of median sternotomy in the presence of a left sternoclavicular joint abscess, he underwent urgent minimally invasive mitral valve surgery. Intraoperative Findings: The MV exhibited massive vegetation and partial valve destruction on the medial side of P2 and throughout P3, along with an annular abscess. The MV and annular abscess were debrided down to the left ventricular muscular layer. Mitral valve replacement was performed with reconstruction of the mitral posterior annulus using a bovine pericardial patch. The postoperative course was uneventful, and the left sternoclavicular joint abscess diminished with intravenous antibiotic therapy. He was discharged on the 36th day after surgery, and no relapse has been observed.

Methadone, which has unique mechanism of long-acting mu receptor agonism paired with N-Methyl-D-Aspartate（NMDA）antagonism, is thought to have potential to control pain no longer responsive to other opioids. Fatal adverse effects of methadone are respiratory suppression and QT interval prolongation, which leads to ventricular tachycardia. Here we report a case of a patient who benefited from starting on methadone in hospital and increasing methadone safely in a home-based care setting. A 79-year-old Japanese woman, who developed local recurrence after resection for primary retroperitoneal leiomyosarcoma, presented with frequent burning pain in right groin area. After receiving palliative radiation therapy, she took oxycodone and adjuvant analgesics but without relief, and began experiencing somnolence. She underwent opioid switching from oxycodone to methadone with her breakthrough pain remarkably improved. When her breakthrough pain recurred after discharge, escalating dosages of methadone was performed successfully with no serious adverse effects even in a home-based care setting, by forming multidisciplinary collaboration for the management of prescribing methadone among healthcare providers near her home.

The main purpose of basic clinical training for housestaff is to acquire the ability to be a primary physician who can properly manage acute medical problems, develop intimate bonds with patients, and provide them with continuous care. We emphasize the importance of training in the office, clinic, or patients' homes. Although residents have so far spent most of their clinical rotations in an inpatient setting, a training program that devotes substantial time to ambulatory care is indispensable to improve basic clinical training in primary care medicine.