ObjectiveTo investigate the mortality level and leading causes of death among the registered residents in Taishun County, Zhejiang Province from 2016 to 2023, as as to provide evidence for the formulation of relevant disease prevention and control strategies. MethodsDeath data of the registered residents in Taishun County were collected from the population death information registration and management system of Zhejiang Province Chronic Disease Surveillance Information Management System and Wenzhou City Disease Prevention and Control Information System. Excel 2021 software was used to calculate the mortality rates and cause-specific rankings of different genders, age groups, and surveillance years. ResultsDuring 2016‒2023, the crude mortality rate (CMR) of the registered residents in Taishun County was 663.97/10⁵, with a standardized mortality rate of 448.33/10⁵. The CMR for males (833.15/10⁵) was 1.73 times higher than that for females (480.77/10⁵). The mortality rate tended to decrease and then increase with age increased, with 78.25% of deaths occurring among individuals aged ≥65 years. The top five causes of death were malignant tumors, cerebral vascular diseases , cardiovascular diseases, chronic respiratory diseases, and injuries/poisoning, collectively accounting for 73.69% of the total deaths. The ranking orders for males and females were not exactly the same. Chronic diseases dominated the causes of death, accounting for 83.85% of the total deaths, from which, malignant tumors and cerebral vascular diseases accounted for 24.45% and 17.79%, respectively. ConclusionStatistically significant differences of mortality rates are observed among individuals from different ages and genders in Taishun County. Chronic diseases, particularly malignant tumors and cerebral vascular diseases, are the main causes of death among the registered residents in Taishun County. Therefore, it is needed to place weight on the prevention and management of chronic diseases, to alleviate the disease burden caused by premature deaths, and to promote the health of the whole population.

Objective To investigate the risk factors associated with cranial nerve impairment in patients with tuberculous meningitis.Methods A total of 121 patients with tuberculous meningitis who were admitted to Huashan Hospital from 2000 to 2011 were reviewed retrospectively.Demographic data (gender,age),course of disease,initial results of cerebral spinal fluid (CSF) tests,occurrence of cranial nerve impairment and prognosis of these patients were collected.All the patients were followed up for at least 3 months,and for those with cranial nerve impairment,the minimum follow-up period was 1 year in order to judge the recovery of cranial nerve impairment.Multivariate analysis was performed to study the associated risk factors.Results Out of 121 patients,22 (18.2 ％)developed cranial nerve impairment.Nerves involved were abducens nerve,oculomotor nerve,optic nerve and auditory nerve,and impairment of single nerve occurred in 9 (40.9 ％),8 (36.4 ％),7(31.8％) and 1(4.5％) patient,respectively.Three cases had more than one group of cranial nerves involved,accounting for 13.6％ of the 22 patients with cranial nerve impairment.The incidence of conscious disturbance was significantly higher in patients with cranial nerve impairment than those without impairment (77 ％ vs 45 ％,P=0.020).Delay in diagnosis (OR =1.017,95 ％ CI:1.001-1.033,P=0.040) and occurrence of conscious disturbance (OR =3.242,95 ％ CI:1.142-9.205,P=0.027) were independent predictive factors of cranial nerve injury.During one-year follow-up,90.9％ of patients were fully recovered from cranial nerve impairment,with a median duration of 1 month (range 0.5-6.0 months).Conclusions Cranial nerve impairment is a common complication in patients with tuberculous meningitis.Delay in diagnosis and occurrence of conscious disturbance were independent predictive factors.Most cranial nerve impairment were reversible,and timely diagnosis and treatment are important ways to reduce complications.

Objective To find a proper way for accurate results of blood counts,and provide reference for the user of 3 cluster blood cell analyzer.Methods Based on the results of blood cell analyzer KX21 and International Consensus Review Rules,set up the criteria for blood cell microscopic examination,1700 blood specimen were detected and the results were analyzed according to the criteria..Statistics analysis were made to evaluate the accordance between warnings of analyzer and manual examination,likewise the reliability of the criteria.Results According to the review rules and slide riview positive criteria[1],the true positive ratio,the false positive ratio,the true negative ratio and the false negative ratio were 11.88%(202/1 700),21.88%(372/1 700),64.29% (1 093/1 700) and 1.94% (33/1 700) respectively..No blast cell and immature cell was missed.Conclusion The smear review criteria suggested by the International Consensus Group could facilitate to establish the review criteria for 3 cluster blood cell analyzer..The review rules used on KX21 blood cell analyzer in this study are suitable for our laboratory.