Objective To investigate the effect of Siwu Wuzi Decoction in the treatment of wet age-related macular degeneration(wAMD)on the levels of vascular endothelial growth factor(VEGF),transforming growth factor-β1(TGF-β1),and inflammatory factors in patients.Methods A total of 216 patients with wAMD were randomly divided into western medicine group(n=108)and integrated Chinese and western medicine group(n=108).The western medicine group received conbercept plus photodynamic therapy(PDT),while the integrated Chinese and western medicine group received con-bercept,PDT,and Siwu Wuzi Decoction.Both groups were treated for 3 months.The traditional Chi-nese medicine syndrome scores,best-corrected visual acuity(BCVA),intraocular pressure,VEGF,TGF-β1,inflammatory factor levels[interleukin(IL)-6,IL-13],quality of life[Chinese Low Vision Quality of Life Scale(CLVQOL)],and clinical efficacy were observed in both groups.Results After treatment,the traditional Chinese medicine syndrome scores decreased in both groups,with the scores in the integrated Chinese and western medicine group being lower than those in the western medicine group(P＜0.05).After treatment,BCVA decreased in both groups,with the BCVA in the integrated Chinese and western medicine group being lower than that in the western medicine group(P＜0.05).After treatment,intraocular pressure increased in both groups,but the intraocu-lar pressure in the integrated Chinese and western medicine group was lower than that in the western medicine group(P＜0.05).After treatment,VEGF and TGF-β1 levels decreased in both groups,with the levels in the integrated Chinese and western medicine group being lower than those in the western medicine group(P＜0.05).After treatment,IL-6 and IL-13 levels decreased in both groups,with the levels in the integrated Chinese and western medicine group being lower than those in the western medicine group(P＜0.05).After treatment,CLVQOL scores increased in both groups,with the scores in the integrated Chinese and western medicine group being higher than those in the western medicine group(P＜0.05).The total effective rate of treatment in the integrat-ed Chinese and western medicine group was 97.22％,which was higher than 85.19％in the west-ern medicine group(P＜0.05).Conclusion Siwu Wuzi Decoction has a good therapeutic effect on wAMD,which can alleviate symptoms,restore vision,reduce intraocular pressure,regulate VEGF,TGF-β1,and inflammatory factor levels,and improve quality of life.

Antley-Bixler syndrome (ABS) is a rare developmental malformation, usually caused by mutations in the fibroblast growth factor 2 (FGFR2) or cytochrome P450 oxidoreductase (POR) genes. This article reports an 18-year-old male patient with both ulcerative colitis and ABS to explore the possible association between the two diseases, to raise clinicians' awareness, and to provide reference value for early diagnosis and treatment in the future.

Antley-Bixler syndrome (ABS) is a rare developmental malformation, usually caused by mutations in the fibroblast growth factor 2 (FGFR2) or cytochrome P450 oxidoreductase (POR) genes. This article reports an 18-year-old male patient with both ulcerative colitis and ABS to explore the possible association between the two diseases, to raise clinicians' awareness, and to provide reference value for early diagnosis and treatment in the future.

Objective: To assess the effects of subchronic intake of high-dose Dendrobium officinale on body weight, food intake, food utilization, and blood biochemical parameters in rats, so as to provide insights into assessment of edible safety of D. officinale. Methods: Eighty SPF-grade SD rats were randomly divided into the low-, medium- and high-dose groups and the control group, of 10 male and 10 female rats in each group. Rats in the low-, medium- and high-dose groups were administered with D. officinale feeds at doses of 2.0, 4.0, and 8.0 g/kg body weight, respectively, while animals in the control group were given basic diet for successive 13 weeks. The rat body weight, food intake, food utilization, and blood biochemical parameters were compared between groups. Results: Normal diet and activity was seen in all rats, and no abnormal syndromes, signs or deaths were found during the study. There were no significant differences in rat body weight, food intake, total weight gain, total food intake, alanine aminotransferase, aspartate aminotransferase, urea nitrogen, creatinine, triacylglycerol, cholesterol, total protein, albumin, albumin/globulin ratio or blood glucose among four groups (P>0.05). The food utilization 7 weeks post-administration [(8.71%±0.78%) vs. (10.54%±1.37%), P<0.05] and the total food utilization [(18.00%±0.41%) vs. (19.51%±1.21%), P<0.05] were significantly lower in male rats in the high-dose group than in the control group. Conclusion Subchronic intake of high-dose D. officinale shows no toxicity in rats, and reduced food utilization may be associated with the health function of D. officinale in male rats.

Objective: To investigate the effects of lactoprotein iron chelates on rats with iron deficiency anaemia (IDA), so as to provide insights into developing and utilizing novel iron supplements. Methods: Seventy weaning female SPF-graded rats of the SD strain were randomly divided into the control group (A), model group (B), ferrous sulfate group (C), lactoferrin group (D), lactoferrin iron chelate group (E), Casein oligopeptide iron chelate group (F) and whey protein oligopeptide iron chelate group (G), with 10 rats in each group. The rats in group A were fed with normal diet, and the others were fed with poor iron diet for IDA modeling. The corresponding interventions were given by intragastric administration once a day. The iron ion concentrations of group C, E, F and G were 2.0 mg/kg, and the protein and oligopeptide concentrations of group D, E, F and G were 2 000 mg/kg. Body weight and hemoglobin of rats were measured weekly during 21-day intervention. At the end, peripheral blood samples were collected, and blood routine, iron metabolism and liver function indicators were determined. Results: After the intervention, among blood routine indicators, the rats in group C, E, F and G showed elevated hemoglobin, red blood cell, mean corpuscular volume and hematocrit, and decreased free protoporphyrin and mean corpuscular hemoglobin concentration when compared with the rats in group B (all P<0.05); among iron metabolism indicators, the rats in group C, E and G showed elevated serum ferritin, the rats in group C, E, F and G showed elevated serum iron, the rats in group C, D, E, F and G showed decreased unsaturated iron binding capacity and total iron binding capacity when compared with the rats in group B (all P<0.05); among liver function indicators, the rats in group E and G showed decreased alanine transaminase when compared with the rats in group B (both P<0.05). Conclusions Lactoprotein alone could not completely improve IDA in rats compared with traditional iron supplement (ferrous sulfate). Lactoprotein iron chelate, especially whey protein oligopeptide iron chelate, could significantly improve IDA, iron reserve and liver function damage in rats.

Objective:To analyze the influencing factors on the prognosis for survival in patients with advanced non-small-cell lung cancer (NSCLC) treated with immune checkpoint inhibitors (ICIs) and to construct a nomogram for predicting the prognosis for survival.Methods:The research was designed as a retrospective study. The subjects were selected from advanced NSCLC patients who visited Qingdao Municipal Hospital from January 2019 to December 2021 and received ICIs. The clinical data of patients was extracted through the hospital diagnosis and treatment system. A Cox proportional risk model was used to analyze the factors affecting the prognosis for survival in patients. Patients were randomly divided into the modeling group and validation group according to a ratio of 7∶3. Using R4.2.1 software, a nomogram was built, and its prediction performance was verified based on the bootstrap repeated sampling method. Patients were divided into low- and high-risk groups according to the nomogram. The overall survival (OS) of patients was described through Kaplan-Meier curve, and the difference between the 2 groups was compared using the log-rank test.Results:A total of 161 patients with advanced NSCLC were included in the analysis, with an age of (65±8.7) years. Among the 161 patients, 127 were male, 113 had a pathological classification of NSCLC as adenocarcinoma, 86 had an Eastern Coperative Oncology Group Performance Status (ECOG PS) score ≥2, and 113 had ICI combined with other treatments. By December 2022, 81 patients (50.3%) had experienced immune-related adverse events (irAEs), of which 14 had grade 3 or 4 irAEs and 15 had irAEs in multiple systems. Eighty-six patients died. Cox regression analysis showed that advanced lung cancer inflammation index (ALI)≥29.8 [hazard ratio ( HR)=0.48, 95% confidence interval ( CI): 0.28-0.85, P=0.011], ECOG PS score ≥2 ( HR=2.17, 95% CI: 1.21-3.90, P=0.009), and having irAEs ( HR=0.40, 95% CI: 0.21-0.76, P=0.005) were prognostic factors for survival in patients with advanced NSCLC treated by ICIs. The nomogram was established based on factors of age, gender, ECOG PS score, irAEs, and ALI, and the total score of each patient was calculated. The patients were divided into the low-risk group (126 cases) and high-risk group (35 cases) according to the optimal cut-off value (183.82) of the receiver operator characteristic curve. The Kaplan-Meier curve and log-rank analysis showed that there was a statistically significant difference in OS between the 2 groups ( P<0.00 1). Conclusion:ALI, ECOG PS score, and irAEs are independent factors affecting the prognosis for survival in advanced NSCLC patients receiving ICIs, and the nomogram constructed based on multiple biological indicators can effectively predict patient prognosis for survival.

Objective:To analyze the influencing factors on the prognosis for survival in patients with advanced non-small-cell lung cancer (NSCLC) treated with immune checkpoint inhibitors (ICIs) and to construct a nomogram for predicting the prognosis for survival.Methods:The research was designed as a retrospective study. The subjects were selected from advanced NSCLC patients who visited Qingdao Municipal Hospital from January 2019 to December 2021 and received ICIs. The clinical data of patients was extracted through the hospital diagnosis and treatment system. A Cox proportional risk model was used to analyze the factors affecting the prognosis for survival in patients. Patients were randomly divided into the modeling group and validation group according to a ratio of 7∶3. Using R4.2.1 software, a nomogram was built, and its prediction performance was verified based on the bootstrap repeated sampling method. Patients were divided into low- and high-risk groups according to the nomogram. The overall survival (OS) of patients was described through Kaplan-Meier curve, and the difference between the 2 groups was compared using the log-rank test.Results:A total of 161 patients with advanced NSCLC were included in the analysis, with an age of (65±8.7) years. Among the 161 patients, 127 were male, 113 had a pathological classification of NSCLC as adenocarcinoma, 86 had an Eastern Coperative Oncology Group Performance Status (ECOG PS) score ≥2, and 113 had ICI combined with other treatments. By December 2022, 81 patients (50.3%) had experienced immune-related adverse events (irAEs), of which 14 had grade 3 or 4 irAEs and 15 had irAEs in multiple systems. Eighty-six patients died. Cox regression analysis showed that advanced lung cancer inflammation index (ALI)≥29.8 [hazard ratio ( HR)=0.48, 95% confidence interval ( CI): 0.28-0.85, P=0.011], ECOG PS score ≥2 ( HR=2.17, 95% CI: 1.21-3.90, P=0.009), and having irAEs ( HR=0.40, 95% CI: 0.21-0.76, P=0.005) were prognostic factors for survival in patients with advanced NSCLC treated by ICIs. The nomogram was established based on factors of age, gender, ECOG PS score, irAEs, and ALI, and the total score of each patient was calculated. The patients were divided into the low-risk group (126 cases) and high-risk group (35 cases) according to the optimal cut-off value (183.82) of the receiver operator characteristic curve. The Kaplan-Meier curve and log-rank analysis showed that there was a statistically significant difference in OS between the 2 groups ( P<0.00 1). Conclusion:ALI, ECOG PS score, and irAEs are independent factors affecting the prognosis for survival in advanced NSCLC patients receiving ICIs, and the nomogram constructed based on multiple biological indicators can effectively predict patient prognosis for survival.

Objective To investigate the short-term clinical effect of CT guided 125Ⅰ radioactive particle therapy in superficial malignant tumor. Methods The clinic data of 28 patients with metastatic superficial malignant tumor in our hospital were analyzed retrospectively.All patients were treated with CT guided 125Ⅰ radioactive particle therapy.The short-term effects,1 year survival rate and 1 year progression free survival rate of the patients were compared.Results Objective remission rate(ORR)and disease control rate(DCR)after 6 months were 92.86% and 100.00%.1 year overall survival and 1 year progression free survival were 96.43%(27/28)and 82.14%(23/28), respectively.The median overall survival and median progression free survival were 26.978 months (95%CI:22.558-31.399)and 16.932 months (95 % CI:14 .471-19.393).There were 27 cases of 0-Ⅱ degree adverse reactions,1 case of grade Ⅲ adverse reactions and no grade Ⅳ adverse reactions.No signs of 125Ⅰ radioactive particle translocation,vascular embolism and vascular rupture were found. Conclusion 125Ⅰ radioactive particle treatment of superficial malignant tumor has a definite short-term curative effect,with overall survival and progression free survival longer and higher safety,which can be considered in clinical application.

Objective To investigate the effect of paclitaxel drug-coated balloon (DCB) dilatation in treating coronary in-stent restenosis (ISR) occurring after drug-eluting stent (DES) implantation,and to observe the long-term changes of the target vascular lumen area in order to clarify the curative effect of paclitaxel DCB in treating ISR.Methods Four patients with ISR whose clinical condition met the DCB indication were selected.According to the standard process,sufficient pre-expansion of ISR was performed first,then paclitaxel DCB dilatation was carried out to dilate the lesion segment of ISR,and no stent was implanted.Both coronary angiography and intravascular ultrasound (IVUS) were performed immediately after the treatment as well as 9 months to measure the minimum lumen area (MLA) and cross-sectional area (SA) of the stent,and the intimal hyperplasia was also been evaluated.Results In all 4 patients,angiography performed immediately after paclitaxel DCB dilatation showed that neither dissection of the dilated segment of the target artery nor obvious residual stenosis was observed.Angiography performed 9 months after the treatment revealed that all dilated segments of the target arteries were patent,and no pronounced restenosis of stent segment was seen.IVUS examination was indicated that MLA became enlarged,SA showed an increasing trend,and intimal hyperplasia showed a tendency to be inhibited.Conclusion For the treatment of ISR,pure paclitaxel DCB dilatation can obtain long-term lumen area enlargement,thus,repeated stent implantation can be avoided,which,in turn,can reduce the risk of ISR recurrence.Paclitaxel DCB dilatation can locally release paclitaxel,which has curative effect on the coronary artery wall to inhibit the excessive proliferation of intima.

Objective To investigate the value of the three-dimensional high-resolution magnetic resonance imaging curve planar reformation(CPR)combined with virtual endoscopy reconstruction in vascular compression of trigeminal neuralgia.Methods 65 pa-tients with trigeminal neuralgia performed three-dimensional MR doubly excited balanced steady-state free precession sequence (3D-FIESTA-C),and CPR combined with virtual endoscopy reconstruction was used to evaluate the relationship of neurovascular anato-my.And 60 cases with microvascular decompression (MVD)surgery were analyzed.Results 65 cases of 3D-FIESTA-C CPR com-bined with MRVE showed responsibility vascular with a positive rate of 92.3% (60/65).60 cases of all patients with the results of surgery showed responsibility blood vessels and oppression parts with 3D-FIESTA-C CPR combined with MRVE,and it was found that the findings of oppression had a good consistency with MVD with the diagnose accordance rate of 95% (57/60).Conclusion Three-dimensional high-resolution magnetic resonance imaging CPR combined with virtual endoscopy reconstruction can be a new method to clearly and accurately show the anatomical relationship between blood vessels and nerves,which helps to improve the posi-tive rate of detection and to give operative guidance.