Objective To investigate the diagnostic value of serum bromodomain-containing pro-tein 4(BRD4)combined with gastrin-17(G-17)in Helicobacter pylori(Hp)-positive early gastric cancer.Methods A total of 88 patients with Hp-positive early gastric cancer admitted to our hospital from September 2021 to September 2023 were selected as early gastric cancer group.Meanwhile,92 patients with Hp-positive precancerous lesions and 80 patients with Hp-positive gastritis admitted dur-ing the same period were selected as precancerous lesion group and gastritis group,respectively.En-zyme-linked immunosorbent assay(ELISA)was used to detect the serum levels of BRD4 and G-17.Multivariate logistic regression analysis was performed to screen the influencing factors of Hp-positive early gastric cancer.Receiver operating characteristic(ROC)curve analysis was used to evaluate the diagnostic value of serum BRD4 and G-17 in Hp-positive early gastric cancer.Results Compared with the gastritis group,the levels of BRD4 and G-17 in the precancerous lesion group and early gastric cancer group were significantly increased(P＜0.05).Furthermore,compared with the precancerous le-sion group,the levels of BRD4 and G-17 in the early gastric cancer group were also significantly elevated(P＜0.05).The proportion of patients with a family history of gastric cancer,those who preferred hot food,cold food,or high-salt food,as well as the levels of PG Ⅱ,BRD4,and G-17 were signifi-cantly higher in the early gastric cancer group than in the non-gastric cancer group,while the level of pepsinogen(PG)Ⅰ was significantly lower(P＜0.05).Logistic regression analysis revealed that preference for hot food,high-salt food,PG Ⅱ,BRD4,G-17,and PG Ⅰ were all influencing factors for Hp-positive early gastric cancer(P＜0.05).The area under the curve(AUC)values for serum BRD4,G-17,and their combination in diagnosing Hp-positive early gastric cancer were 0.793,0.830,and 0.912,respectively.The diagnostic efficacy of the combined detection was superior to that of single detection(P＜0.05).Conclusion The serum levels of BRD4 and G-17 are elevated in patients with Hp-positive early gastric cancer,and both exhibit certain diagnostic value for Hp-positive early gastric cancer,suggesting their potential as serum biomarkers for the diagnosis of Hp-positive early gastric cancer.

Objective To explore the effect of arthroscopic double locking ring suture technique on shoulder joint function in small and medium-sized patients with rotator cuff tear.Methods From January 2020 to June 2022,54 small and medium-sized patients with rotator cuff tear were selected and randomly divided into control group and treatment group with 27 cases in each group.The control group was repaired by conventional single-row modified Mason-Allen technique,while the treatment group was repaired by arthroscopic double locking ring suture technique.The operation time,blood loss,total hospitalization time,the clinical efficacy and recurrence rate 6 months after operation of the two groups were compared.The pain at different time points,abduction of shoulder joint,University of California at Los Angeles(UCLA)scale,American Shoulder and Elbow Surgeons(ASES)scale and Constant-Murley scale before and 3 months after operation were compared.The incidence of joint stiffness was followed up for 6 months.Results The operation time in the treatment group was significantly shorter than that in the control group,with statistical significance(P＜0.05).After 6 months'follow-up,the total excellent and good rate in the treatment group was significantly higher than that in the control group,with statistical significance(P＜0.05).At the 1,3 and 6 months after operation,the visual analogue scale(VAS)of the two groups decreased compared with that before operation,and the treatment group was lower than that of the control group,with statistical significance(P＜0.05).Three months after operation,the UCLA scale,ASES scale and Constant-Murley scale of the two groups were higher than those before operation,and the treatment group was higher than that of the control group,and the differences were statistically significant(P＜0.05).At the 1,3 and 6 months after operation,the abduction range of the patients in the two groups increased compared with that before operation,and the differences were statistically significant(P＜0.05).During the follow-up of 6 months,the incidence of joint stiffness in the treatment group was 3.70%,which was significantly lower than that in the control group(29.63%),and the differences were statistically significant(P＜0.05).After 6 months'follow-up,the recurrence rate in the treatment group was 0.00%,which was significantly lower than that in the control group(18.52%),with statistical significance(P＜0.05).Conclusion Small and medium-sized patients with rotator cuff tears can be treated by arthroscopic double locking ring suture technology,which can shorten the operation time,effectively relieve the pain of patients,improve shoulder joint mobility,improve shoulder joint function,reduce the incidence and recurrence rate of joint stiffness,and improve clinical efficacy.

Objective To explore the effect of arthroscopic double locking ring suture technique on shoulder joint function in small and medium-sized patients with rotator cuff tear.Methods From January 2020 to June 2022,54 small and medium-sized patients with rotator cuff tear were selected and randomly divided into control group and treatment group with 27 cases in each group.The control group was repaired by conventional single-row modified Mason-Allen technique,while the treatment group was repaired by arthroscopic double locking ring suture technique.The operation time,blood loss,total hospitalization time,the clinical efficacy and recurrence rate 6 months after operation of the two groups were compared.The pain at different time points,abduction of shoulder joint,University of California at Los Angeles(UCLA)scale,American Shoulder and Elbow Surgeons(ASES)scale and Constant-Murley scale before and 3 months after operation were compared.The incidence of joint stiffness was followed up for 6 months.Results The operation time in the treatment group was significantly shorter than that in the control group,with statistical significance(P＜0.05).After 6 months'follow-up,the total excellent and good rate in the treatment group was significantly higher than that in the control group,with statistical significance(P＜0.05).At the 1,3 and 6 months after operation,the visual analogue scale(VAS)of the two groups decreased compared with that before operation,and the treatment group was lower than that of the control group,with statistical significance(P＜0.05).Three months after operation,the UCLA scale,ASES scale and Constant-Murley scale of the two groups were higher than those before operation,and the treatment group was higher than that of the control group,and the differences were statistically significant(P＜0.05).At the 1,3 and 6 months after operation,the abduction range of the patients in the two groups increased compared with that before operation,and the differences were statistically significant(P＜0.05).During the follow-up of 6 months,the incidence of joint stiffness in the treatment group was 3.70%,which was significantly lower than that in the control group(29.63%),and the differences were statistically significant(P＜0.05).After 6 months'follow-up,the recurrence rate in the treatment group was 0.00%,which was significantly lower than that in the control group(18.52%),with statistical significance(P＜0.05).Conclusion Small and medium-sized patients with rotator cuff tears can be treated by arthroscopic double locking ring suture technology,which can shorten the operation time,effectively relieve the pain of patients,improve shoulder joint mobility,improve shoulder joint function,reduce the incidence and recurrence rate of joint stiffness,and improve clinical efficacy.

Chinese materia medica(CMM) industry is one of the most national identity in China′s industries.According to the development situation in recent years,putting forward some reasonable ideas will promote better and faster development of the CMM industry.In this paper,through the literature review combined with CMM industry development status,the current structure of CMM industry was analyzed.And based on the concept of the industrial chain,the CMM industry chain structure was analyzed and described.The proposal of building a harmonious CMM industry chain was put forward clearly,which will conform to the requirements of the CMM industry development.Above all,this article has provided some constructive ideas for future development of CMM industry.