To investigate body composition and associated factors in adolescents undergoing long-term regular sports training.

Living systematic review (LSR) is a systematic review methodology that incorporates regular updates to integrate new evidence, aiming to rapidly reflect the latest research findings. Although LSRs are increasingly adopted in clinical fields, their reporting quality remains inconsistent and lack of standardized guidelines. To standardize LSR reporting, the PRISMA 2020 statement has released an extension checklist (PRISMA-LSR). This paper describes the background of PRISMA-LSR release and main revisions, and interprets it with examples, with the goal of guiding future LSR research and enhancing reporting quality.

Vulvar squamous cell carcinoma(VSCC)is a rare but gradually increasing cancer of the female reproductive system,characterized by a high recurrence rate and poor prognosis.In recent years,significant progress has been made in understanding the etiology,diagnosis,and treatment of VSCC.The classification criteria for VSCC have gradually shifted from histological to molecular levels associated with HPV and P53 protein.More importantly,different molecular subtypes have been proven to exhibit distinct genomic mutations and clinical pro-gnoses.Consequently,the molecular subtypes of VSCC are expected to guide the selection of targeted therapies,immunotherapies,and sur-gical strategies.Simultaneously,the evolution of inguinal lymph node management from traditional surgery to individualized surgical strategies,along with new treatment methods,including electrochemotherapy,targeted therapy,and immunotherapy,has provided more options for the clinical management of VSCC.This review integrates the literature from the past five years to elucidate the latest viewpoints and technologies in the clinical diagnosis and treatment of VSCC,aiming to provide clinicians with a comprehensive perspective to promote a deeper understanding of and management of VSCC.

Vulvar squamous cell carcinoma(VSCC)is a rare but gradually increasing cancer of the female reproductive system,characterized by a high recurrence rate and poor prognosis.In recent years,significant progress has been made in understanding the etiology,diagnosis,and treatment of VSCC.The classification criteria for VSCC have gradually shifted from histological to molecular levels associated with HPV and P53 protein.More importantly,different molecular subtypes have been proven to exhibit distinct genomic mutations and clinical pro-gnoses.Consequently,the molecular subtypes of VSCC are expected to guide the selection of targeted therapies,immunotherapies,and sur-gical strategies.Simultaneously,the evolution of inguinal lymph node management from traditional surgery to individualized surgical strategies,along with new treatment methods,including electrochemotherapy,targeted therapy,and immunotherapy,has provided more options for the clinical management of VSCC.This review integrates the literature from the past five years to elucidate the latest viewpoints and technologies in the clinical diagnosis and treatment of VSCC,aiming to provide clinicians with a comprehensive perspective to promote a deeper understanding of and management of VSCC.

Purpose/Significance The scoping review summarizes the application of large language models in clinical practice,and provides references for their promotion.Method/Process PubMed,Embase,Wanfang and CNKI databases are searched to screen the lit-erature related to the application of large language models in clinical practice,and the content of the included literature is extracted,sum-marized and analyzed.Result/Conclusion Large language models have application value in providing treatment suggestions,assisting disease diagnosis,health education,analyzing text image data,etc.However,their performance in answer accuracy and individualization is not satisfactory.In general,large language models show significant potential in clinical practice,but necessary measures must be taken to control the application risks and confirm the scope of application.

Objective To explore the relationship between urinary activin A and neonatal hypoxic-ischemic encephalopathy(HIE).Methods 50 full-term neonatal with HIE were selected as the observation group,48 normal full-term neonatal in the same period were selected as the normal control group randomly.Within 7 days after birth,the observation group was divided into the group of 30 patients with mild HIE and the group of 20 patients with moderate and severe HIE,according to diagnostic criteria and clinical grading of neonatal HIE.The levels of urinary activin A in two groups after birth at different time(2,12,24,48,72h)was determined by using ELISA method.Results The levels of urinary activin A in moderate and severe HIE group was significantly higher than than in the normal control group(P＜0.01)and mild HIE group(P＜0.01);The levels of urinary activin A in the normal control group and mild HIE group showed no significant differences(P＞0.05).Urinary activin A level＞70 ng/L for the critical value to determine the occurrence of moderate and severe HIE,the sensitivity and specificity of 2 h urinary activin A levels were separately 86％ and 99％;The sensitivity and specificity of 12～72 h urinary activin A levels were separately 100％ and 98％.Conclusion The correlation between the level of urinary activin A and the severity of HIE was positive,the level of urinary activin A had a high degree of sensitivity and specificity for determine the incidence of moderate and severe HIE,it provided an important basis for diagnosis of moderate and severe HIE.