Objective To explore the practical effect of clinical pharmacists carrying out the comprehensive medication management （CMM） in patients with diabetes. Methods According to the American CMM care process, 2 patients with diabetes were taken as examples，clinical pharmacists collected relevant drug information of the patients, assessed drug-related problems （DRPs） with the help of the European Medicine and Healthcare Network （PCNE） classification system, proposed relevant intervention plans, and tracked the final solution of DRPs. Results Clinical pharmacists identified DRPs in a diabetic patient by collecting medication information. Using the PCNE classification tool, causes such as poor medication adherence, insufficient self-monitoring of blood glucose, and improper protective measures during intravenous medication administration were analyzed. Through collaborative interventions with physicians, nurses, and patients, all DRPs were effectively resolved. Conclusion Clinical pharmacists run the CMM pharmaceutical care process, which could provide professional comprehensive drug management services for chronic disease patients, improve the work efficiency of clinical pharmacists in pharmaceutical care, and ensure the safety and effectiveness of patients’ drug treatment.

Objective To study the release profile of curcumin and piperine from the compound self-microemulsion. Methods The release of curcumin and piperine in vitro was investigated by dynamic dialysis under the condition of phosphate buffer of pH 4.8 and 7.5 with 0.75% Tween-80. Results The cumulative release rates of curcumin in pH 4.8 and pH 7.5 were 94.85% and 84.38% in 108 h, respectively. The cumulative release rates of piperine were 92.85% and 90.05% in 36 h, separately. Conclusion Curcumin and piperine in self-microemulsion have sustained release properties and released more in the acidic environment similar to the environment in tumors.

Objective Asiatic acid is the main medicinal component of aursane pentacyclic triterpene and possessed various biological activities. In order to obtain better active Asiatic acid analogues, microbial transformation was used for structural modification. Methods Asiatic acid was biotransformed by Syncephalum racemosum CGMCC 3.2500. The structure of the compound was identified by high resolution electrospray ionization mass spectroscopy (HR-ESI-MS) and nuclear magnetic resonance spectroscopy (i.e., ¹H NMR、¹³C NMR、¹H-¹³C HSQC、¹H-¹³C HMBC、¹H-¹H NOESY). Results The structure of the compound was determined as 2-oxo-3α, 15α, 23-trihydroxyurs-12-en-28-oic acid which was a new compound. Conclusion Syncephalum racemosum CGMCC 3.2500 can modify the structure of Asiatic acid and obtain Asiatic acid analogues.