Objective To investigate the association between excessive daytime sleepiness (EDS) and cardiovascular health. Methods Data from the NHANES national representative database was used, and based on the EDS frequency questionnaire, the adults were divided into groups A，B，C, and D. The adults in group A had no daytime sleepiness (DS) group and chose the answer of "never", those in group B had mild DS and chose the answer of "rarely, sometimes (1-4 times a month)", those in group C had EDS and chose the answer of "often (5-15 times a month)", and those in group D had high-frequency EDS and chose the answer of "almost always (16-30 times a month)". The logistic regression analysis was used to estimate the degree of association of EDS with cardiovascular risk factors (hypertension, diabetes, hypercholesterolemia, and obesity) and cardiovascular event outcomes (including coronary artery disease, congestive heart failure, and stroke). Result This study included 12 786 unweighted participants from the four NHANES study periods of 2005-2008 and 2015-2018. Compared with the adults without DS, the adults with high-frequency EDS had a significantly higher proportion of the adults with a young age, female sex, a high body mass index, abdominal obesity, smoking, drinking, obstructive sleep apnea, sleep duration<6 hours,existing sleep problems, or a comorbidity of depression. The logistic regression analysis showed that high-frequency EDS was an independent risk factor for coronary artery disease (OR=1.02,95% CI 1.00-1.04,P=0.044) and stroke (OR=1.02, 95%CI 1.00-1.03,P=0.031). Conclusion High-frequency EDS is an independent risk factor for coronary artery disease and stroke. EDS should be taken seriously in clinical practice, and cardiovascular health management should be strengthened for EDS patients.