Objective To study the economic burden caused by healthcare-associated infection(HAI)in patients with severe acute pancreatitis(SAP),and provide theoretical basis for formulating HAI prevention and control measures.Methods Patients with SAP discharged from a tertiary first-class hospital in Jiangxi Province from July 1,2023 to June 30,2024 were selected as the study subjects.Information including demographic characteristics,clinical data,and hospitalization expense were collected.Patients were divided into a HAI group and a non-HAI group according to HAI occurrence.A propensity score matching(PSM)method was used to conduct a 1∶2 ma-tching,and differences in the length of hospital stay and hospitalization expense between the two groups of patients after PSM were compared.Results A total of 709 patients were included in the analysis,out of which 65 cases ex-perienced HAI,with a HAI incidence of 9.17％.After PSM,all 65 patients in the HAI group were successfully matched.The length of hospital stay,total hospitalization expense,expenses of medication and hygiene product of patients in the HAI group were all higher than those in the non-HAI group,and differences were all statistically sig-nificant(all P＜0.001).Patients who experienced≥2 episodes of HAI had a higher economic burden than those who experienced only once(P＜0.05).HAI of bloodstream,abdomen,digestive system,and respiratory system significantly increased the economic burden of patients(all P＜0.05).Conclusion HAI in SAP patients can extend the length of hospital stay and increase economic burden of patients.Targeted infection prevention and control mea-sures should be formulated to reduce the incidence of HAI and save medical resources.

Objective To study the economic burden caused by healthcare-associated infection(HAI)in patients with severe acute pancreatitis(SAP),and provide theoretical basis for formulating HAI prevention and control measures.Methods Patients with SAP discharged from a tertiary first-class hospital in Jiangxi Province from July 1,2023 to June 30,2024 were selected as the study subjects.Information including demographic characteristics,clinical data,and hospitalization expense were collected.Patients were divided into a HAI group and a non-HAI group according to HAI occurrence.A propensity score matching(PSM)method was used to conduct a 1∶2 ma-tching,and differences in the length of hospital stay and hospitalization expense between the two groups of patients after PSM were compared.Results A total of 709 patients were included in the analysis,out of which 65 cases ex-perienced HAI,with a HAI incidence of 9.17％.After PSM,all 65 patients in the HAI group were successfully matched.The length of hospital stay,total hospitalization expense,expenses of medication and hygiene product of patients in the HAI group were all higher than those in the non-HAI group,and differences were all statistically sig-nificant(all P＜0.001).Patients who experienced≥2 episodes of HAI had a higher economic burden than those who experienced only once(P＜0.05).HAI of bloodstream,abdomen,digestive system,and respiratory system significantly increased the economic burden of patients(all P＜0.05).Conclusion HAI in SAP patients can extend the length of hospital stay and increase economic burden of patients.Targeted infection prevention and control mea-sures should be formulated to reduce the incidence of HAI and save medical resources.

Objective: To evaluate the feasibility and accuracy of deep learning in CT image segmentation and further lesion-volume assessment of spontaneous intracerebral hemorrhage. Methods: A total of 1 223 cases of spontaneous intracerebral hemorrhage including parenchymal hemorrhage, ventricular hemorrhage, subarachnoid hemorrhage and mixture hemorrhage, from April 2016 to April 2018 in Tianjin Medical University General Hospital, were retrospectively enrolled and analyzed. The patients were randomly divided into training set (905 cases), validation set (156 cases) and test set (162 cases), among each group, the number of parenchymal hemorrhage was 498, 107 and 100, respectively. The bleeding area manually outlined by physician was served as the reference standard to build the segmentation model and to evaluate the performance of the validation set. Patients were divided into 3 groups according to the volume calculated by reference standard. The volume of hematoma in group 1 was less than 5 ml, while group 2 was 5-25 ml, and group 3 was more than 25 ml. Comparison of the hematoma volume calculated by segmentation model and that calculated by ABC/2 formula was conducted in 97 simple intraparenchymal hemorrhage cases. Results: In 162 cases of test set, the Dice coefficients of the segmentation model were 0.87, 0.85, 0.67 and 0.77 in parenchymal hemorrhage, intraventricular hemorrhage, subarachnoid hemorrhage and mixture hemorrhage, respectively. The estimated hematoma volume in the 97 intraparenchymal hemorrhage cases calculated by the segmentation model was (29.55±37.69) ml, and that calculated by the ABC/2 formula was (24.04±31.22) ml. Compared with reference standard, the absolute errors of three segmentation model were (0.52±0.54), (1.53±1.22) and (7.93±8.49) ml in group 1, 2 and 3 respectively. The absolute errors of the ABC/2 formula were (0.68±0.60), (3.16±2.90) and (19.31±17.23) ml in group 1, 2 and 3. Conclusion Deep learning based segmentation model improved detection of intraparenchymal hematoma volume, compared with ABC/2 formula.

Objective To analyze the etiology and clinical characteristics of infectious mononucleosis-like syndrome (IMLS).Methods Eighty-seven children with IMLS in a hospital from January 2006 to September 2013 were per-formed pathogenic detection,then clinical features were summarized and analyzed.Results The top 5 pathogens in IMLS were Mycoplasma pneumoniae (MP,n=20 ),cytomegalovirus (CMV,n=13),simplex herpes virus(HSV, n=11),Chlamydia (CP,n=11),and parvovirus B19 (Hpv B19,n=9 ),clinical manifestations of all kinds of dis-eases were similar,but the occurrence rates were slightly different.MP infection were mainly fever,hepatospleno-megaly,and lymphadenopathy,and most were associated with respiratory complications(including laryngitis,bron-chitis,and pneumonia),CMV infection were also showed fever and hepatosplenomegaly,but the latter was more ob-vious;rubella patients didn’t appear skin rash,but the other symptoms were obvious.Conclusion Etiologies of in-fectious mononucleosis-like syndrome are varied,MP infection is most common,the next is CMV.Pathogens should be ascertained to provide theoretical basis of treatment.

Objective To observe and analyze the curative effect of the leukocyte elevating therapy on treatment of subitum children with agranulocytosis.Methods 60 subitum children with agranulocytosis were randomly divided into the observation group and the control group,30 cases in each group.The control group was treated with the conventional treatments,while the ob-servation group was treated with granulocyte colony stimulating factor (G-CSF)subcutaneous in-jection on the basis of the control group.At 2nd day,4th day,6th day,8th day,14th day of the duration,the classification and the counting of the peripheral blood samples of the children in the two groups were detected and compared.Results The proportion of the children with aplastic anemia in the observation group at 6th day was significantly lower than that of the control group (P <0.05).The leukocyte and neutrophil countings in the peripheral blood of the children in the two groups at 4th day of the duration decreased significantly (P <0.05),the level at 6th day was significantly higher than those at 2nd day or 4th day (P <0.05).The levels restored to normal levels at 14th day of the duration.At 6th day or 8th day of the duration,the leukocyte and neu-trophil countings in the peripheral blood of the children in the observation group were significantly higher than those of the control group (P <0.05).Conclusion Application of G-CSF in eleva-tion of the leukocyte can significantly improve the leukocyte and neutrophil levels in the peripheral blood of the patients with subitum,reduce the probability of aplastic anemia in the children,and help the children pass through the key course safely and smoothly.

Objective To observe and analyze the curative effect of the leukocyte elevating therapy on treatment of subitum children with agranulocytosis.Methods 60 subitum children with agranulocytosis were randomly divided into the observation group and the control group,30 cases in each group.The control group was treated with the conventional treatments,while the ob-servation group was treated with granulocyte colony stimulating factor (G-CSF)subcutaneous in-jection on the basis of the control group.At 2nd day,4th day,6th day,8th day,14th day of the duration,the classification and the counting of the peripheral blood samples of the children in the two groups were detected and compared.Results The proportion of the children with aplastic anemia in the observation group at 6th day was significantly lower than that of the control group (P <0.05).The leukocyte and neutrophil countings in the peripheral blood of the children in the two groups at 4th day of the duration decreased significantly (P <0.05),the level at 6th day was significantly higher than those at 2nd day or 4th day (P <0.05).The levels restored to normal levels at 14th day of the duration.At 6th day or 8th day of the duration,the leukocyte and neu-trophil countings in the peripheral blood of the children in the observation group were significantly higher than those of the control group (P <0.05).Conclusion Application of G-CSF in eleva-tion of the leukocyte can significantly improve the leukocyte and neutrophil levels in the peripheral blood of the patients with subitum,reduce the probability of aplastic anemia in the children,and help the children pass through the key course safely and smoothly.