Objective:To design a simulated navigation scheme of cranial puncture based on three dimensional (3D) infrared optical locator,so as to achieve accurately puncture of trigeminal nerve semilunar node and ensure maximization of the effect of clinical surgery. Methods:The experiment used computed tomography (CT) to scan skull phantom,and imported its data into 3D Slicer system. Spatial coordinates of skull phantom,surgical tool,surgical needle and needle tips were converted to 3D Slicer through the 3D optical locator and 3D Slicer's image guided therapy (IGT) module,so as to display the relationship of spatial position between needle tip and skull model in real-time,and to verify the accuracy of actual measurement of 3D optical locator,and the located accuracy of navigation scheme of skull puncture. Results:After the verification of 10 verification tests,the defined accuracy of 3D optical locator reached 0.2 mm. The operation of virtual world of 3D Slicer system can real-timely and accurately correspond with that of real world. The measured result of simulated navigation and position was (0.87±0.49) mm. Conclusion:The testing results verify the accuracy of navigation of simulated cranial puncture,which has favorable effect,and which can provide a reference for planning navigation scheme before percutaneous puncture balloon compression (PBC) surgery.

Objective:To design a simulated navigation scheme of cranial puncture based on three dimensional (3D) infrared optical locator,so as to achieve accurately puncture of trigeminal nerve semilunar node and ensure maximization of the effect of clinical surgery. Methods:The experiment used computed tomography (CT) to scan skull phantom,and imported its data into 3D Slicer system. Spatial coordinates of skull phantom,surgical tool,surgical needle and needle tips were converted to 3D Slicer through the 3D optical locator and 3D Slicer's image guided therapy (IGT) module,so as to display the relationship of spatial position between needle tip and skull model in real-time,and to verify the accuracy of actual measurement of 3D optical locator,and the located accuracy of navigation scheme of skull puncture. Results:After the verification of 10 verification tests,the defined accuracy of 3D optical locator reached 0.2 mm. The operation of virtual world of 3D Slicer system can real-timely and accurately correspond with that of real world. The measured result of simulated navigation and position was (0.87±0.49) mm. Conclusion:The testing results verify the accuracy of navigation of simulated cranial puncture,which has favorable effect,and which can provide a reference for planning navigation scheme before percutaneous puncture balloon compression (PBC) surgery.

Objective To assess the efficacy and tolerability of continuous low-dose cyclophosphamide and prednisone regimen(CP)as salvage therapy for multiple myeloma patients with severe complications.Methods The CP regimen consisted of oral cyclophosphamide at 50 mg and oral prednisone at 15 mg daily.The patients were withdrawn if the response was invalid or not improved after 6 months,and follow-up was carried on if CR maintained for 6 weeks.A total of 23 consecutive patients received the CP regimen,with 18 patients having severe complications,and 5 patients unwilling to accept conventional chemotherapy because of severe infection.All patients had received one to four regimens before.Results Among 23 patients with CP regimen,the overall response rate(CR+VGPR+PR)was 61%,with 1 CR,4 VGPR,9 PR,3 MR and 6 PD.The quality of life and physical conditions were improved significandy.Conclusion Our data showed that CP was an effective,well-tolerated,and convenient regimen as salvage therapy for MM with severe complications.