Objective To observe the clinical efficacy and safety of external application of Piyan Formula in treating epidermal growth factor receptor tyrosine kinase inhibitor(EGFR-TKIs)-related rashes.Methods Sixty cases of EGFR-TKIs-related rash patients were randomly allocated into either a treatment group or a control group.The treatment group received external application of Piyan Formula to the rash area twice daily for 14 days.The control group received external application of fucidic acid cream to the rash area twice daily for 14 days.Changes in rash grading,itching grading,quality of life scores and adverse event were observed and recorded in both groups.At the same time,levels of hypersensitive C-reactive protein,interleukin(IL)-6,and IL-1β were measured before treatment and 24 hours after treatment.Results After treatment,the rash severity,itching severity,and quality of life scores were notably lower in the treatment group compared to the control group(P<0.05).The levels of hypersensitive C-reactive protein,IL-6,and IL-1β exhibited a significant decrease compared to their pre-treatment values.(P<0.05).Compared with the control group,the levels of hypersensitive C-reactive protein,IL-6,and IL-1β decreased in the treatment group,with statistically significant differences(P<0.05).No adverse events related to Piyan Formula or fucidic acid cream occurred during the treatment process.Conclusion External application of Piyan Formula in treating EGFR-TKIs-related rashes shows significant clinical efficacy,can effectively reduce the levels of inflammatory factors,and has high safety,thus warranting clinical promotion.

OBJECTIVE：To develop a metho d for determining the plasma concentration of sulfasalazine （SSZ）metabolite sulfapyridine（SP）in rats ，and to investigate the effects of esomeprazole （ESOM）on the pharmacokinetic behavior of SSZ in rats. METHODS：Male SD rats were randomly divided into SSZ group and SSZ+ESOM group ，with 6 rats in each group. SSZ+ESOM group were given Esomeprazole enteric-coated tablets [ 90 mg/（kg·d）] intragastrically for 14 days. On the 15th day ，the rats in 2 groups were given Sulfasalazine enteric coated tablets （90 mg/kg）intragastrically，and blood sample was collected from the inner canthus at 0.5，1，1.5，2，3，4，6，8，10，12，24，36，48，72 h after administration. After protein precipitation with methanol ， using diazepam as internal standard ，Agilent XDR-C 18 column was adopted with methanol- 0.1％ formic acid solution （gradient elution）as mobile phase. The concentration of SSZ metabolite SP in plasma was determined by LC-MS/MS. The pharmacokinetic parameters were calculated by using DAS 3.0.1 software and compared between 2 groups. RESULTS ：The linear range of SP were 2-1 000 ng/mL. The methodology met the requirements of Chinese Pharmacopeia . There was no statistical significance in pharmacokinetic parameters of SP between 2 groups，such as AUC 0－t，tmax，t1/2z，cmax，MRT0－t（P＞0.05）. CONCLUSIONS ：The established method is simple ，rapid and sensitive ；it can be used for the concentration determination of SSZ metabolite SP in plasma. ESOM has no significant effect on the pharmacokinetic behavior of SSZ in rats.

ObjectiveTo observe the clinical efficacy ofTong Du Tiao Shen(unblocking the Governor Vessel and regulating spirit) needling method plus Nimodipine in treating vascular dementia.MethodSixty patients with vascular dementia were randomized into a treatment group and a control group, 30 in each group. The control group was intervened by oral administrationof Nimodipine, while the treatment group was additionally intervened byTong Du Tiao Shenneedling method. Two weeks were taken asa treatment course, and the intervention lasted 2 courses. The Mini-Mental State Examination (MMSE) and Activities of Daily Life (ADL) were evaluated and compared before and after intervention, and the therapeutic efficacy was determined.Result After intervention, there were significant differences in comparing MMSE and ADL scores between the two groups (P<0.05). ConclusionTong Du Tiao Shenneedling method plus Nimodipine is effective in treating vascular dementia, and worth promotion in clinic.

Objective To observe the effects of HBO combined with comprehensive drug treatment on 58 cases of acute face neuritis.Methods In accordance with the case selection criteria,116 case of acute face neuritis were chosen for the study.With the knowledge and consent of the patients and following the signing of the letter of agreement and with the agreement of the Hospital Ethic Committee,1 16 patients were divided into 2 groups:the experimental group and the control group,each consisting of 58 patients.The patients in the control group were only treated with regular drug treatment,while the patients in the experimental group were offered HBO treatment and regular drug treatment as well.They were all treated for a succession of 3 weeks and observation was made on the therapeutic results of both groups.Results After 3 weeks of treatment,facial nerve function scores for the patients of both groups all increased when compared with those before treatment,with statistical significance (P ＜ 0.01).Scores for the patients in the experimental group were significantly higher than those for the patients of the control group (P ＜ 0.05).Conclusions Comprehensive HBO treatment seemed to produce significant effects in the treatment of acute face neuritis.

Objective To observe the effects of HBO combined with comprehensive drug treatment on 58 cases of acute face neuritis.Methods In accordance with the case selection criteria,116 case of acute face neuritis were chosen for the study.With the knowledge and consent of the patients and following the signing of the letter of agreement and with the agreement of the Hospital Ethic Committee,1 16 patients were divided into 2 groups:the experimental group and the control group,each consisting of 58 patients.The patients in the control group were only treated with regular drug treatment,while the patients in the experimental group were offered HBO treatment and regular drug treatment as well.They were all treated for a succession of 3 weeks and observation was made on the therapeutic results of both groups.Results After 3 weeks of treatment,facial nerve function scores for the patients of both groups all increased when compared with those before treatment,with statistical significance (P ＜ 0.01).Scores for the patients in the experimental group were significantly higher than those for the patients of the control group (P ＜ 0.05).Conclusions Comprehensive HBO treatment seemed to produce significant effects in the treatment of acute face neuritis.