With the advent of era of tumor immunotherapy,effect of intestinal flora in immunotherapy has attracted much attention.A large number of studies have confirmed the role of traditional Chinese medicine in regulating intestinal flora.Based on this,this paper discusses and summarizes the effect and mechanism of traditional Chinese medicine intervention on tumor immune checkpoint inhibitors(ICIs)treatment,providing a theoretical basis for in-depth understanding of the correlation between traditional Chinese medicine,intestinal flora and immunotherapy,and also providing new ideas for improving the efficacy of tumor immunotherapy and reducing immune-related adverse reactions.

Objective:To explore the impact of family cohesion and adaptability on positive coping of adolescents with self-injurious behaviors, and the mediating role of self-efficacy in their relationships.Methods:From January 2023 to June 2025, a total of 123 adolescents with self-injurious behaviors from both the outpatient and inpatient departments of Bishan Hospital of Chongqing Medical University were assessed using the family adaptability and cohesion evaluation scale-Ⅱ(FACES-Ⅱ), simplified coping style questionnaire(SCSQ), and general self-efficacy scale(GSES). Descriptive and correlation analysis were conducted using SPSS 25.0 software, while AMOS 24.0 software was employed to construct and test a mediation model.Results:(1)The levels of family cohesion (51.00 (45.00, 60.00)), the family adaptability (34.50±8.88), positive coping (1.00 (0.67, 1.33)) and self-efficacy (23.39±8.23) among adolescents engaging in self-injurious behaviors demonstrated statistically significant positive correlation with each other ( r=0.276-0.795, P<0.01). (2) Family cohesion and adaptability directly predicted positive coping, with a direct effect of 0.291(95% CI=0.099-0.462, P<0.05) accounting for 73.12% of the total effect. Family cohesion and adaptability also indirectly predicted positive coping through self-efficacy, with an indirect effect of 0.107(95% CI=0.027-0.203, P<0.05) accounting for 26.88% of the total effect. The total effect was 0.398(95% CI=0.178-0.577, P<0.05). Conclusion:Family cohesion and adaptability can directly predict the positive coping behaviors among adolescents with self-injurious behaviors, and can also serve as indirect predictors of positive coping behaviors through the mediating role of self-efficacy.

With the advent of era of tumor immunotherapy,effect of intestinal flora in immunotherapy has attracted much attention.A large number of studies have confirmed the role of traditional Chinese medicine in regulating intestinal flora.Based on this,this paper discusses and summarizes the effect and mechanism of traditional Chinese medicine intervention on tumor immune checkpoint inhibitors(ICIs)treatment,providing a theoretical basis for in-depth understanding of the correlation between traditional Chinese medicine,intestinal flora and immunotherapy,and also providing new ideas for improving the efficacy of tumor immunotherapy and reducing immune-related adverse reactions.

Objective:To explore the impact of family cohesion and adaptability on positive coping of adolescents with self-injurious behaviors, and the mediating role of self-efficacy in their relationships.Methods:From January 2023 to June 2025, a total of 123 adolescents with self-injurious behaviors from both the outpatient and inpatient departments of Bishan Hospital of Chongqing Medical University were assessed using the family adaptability and cohesion evaluation scale-Ⅱ(FACES-Ⅱ), simplified coping style questionnaire(SCSQ), and general self-efficacy scale(GSES). Descriptive and correlation analysis were conducted using SPSS 25.0 software, while AMOS 24.0 software was employed to construct and test a mediation model.Results:(1)The levels of family cohesion (51.00 (45.00, 60.00)), the family adaptability (34.50±8.88), positive coping (1.00 (0.67, 1.33)) and self-efficacy (23.39±8.23) among adolescents engaging in self-injurious behaviors demonstrated statistically significant positive correlation with each other ( r=0.276-0.795, P<0.01). (2) Family cohesion and adaptability directly predicted positive coping, with a direct effect of 0.291(95% CI=0.099-0.462, P<0.05) accounting for 73.12% of the total effect. Family cohesion and adaptability also indirectly predicted positive coping through self-efficacy, with an indirect effect of 0.107(95% CI=0.027-0.203, P<0.05) accounting for 26.88% of the total effect. The total effect was 0.398(95% CI=0.178-0.577, P<0.05). Conclusion:Family cohesion and adaptability can directly predict the positive coping behaviors among adolescents with self-injurious behaviors, and can also serve as indirect predictors of positive coping behaviors through the mediating role of self-efficacy.

Exosomes are a class of extracellular vesicles with a structure of lipid bilayer-membrane. In the central nervous system (CNS), exosomes can be secreted from both neurons and glial cells. Exosomes released into the extracellular matrix can freely cross the blood-brain barrier and function as crucial carriers of cellular communication and substance exchange in the CNS. Exosomes play a key role in the pathological process of mental disorders such as schizophrenia, depression, and bipolar disorder, and they have the potential to be used as a targeted carrier of antipsychotic medications. Exosomes are likely to become a new tool in the future to aid in the early prevention, accurate diagnosis, and effective treatment for people with mental disorders.
Humans ; Exosomes/physiology* ; Extracellular Vesicles/physiology* ; Central Nervous System ; Mental Disorders ; Blood-Brain Barrier