Objective To construct a postoperative resistance exercise program for patients with gastric cancer,and to explore its intervention effect on symptom clusters and quality of life.Methods Based on the interactive attainment theory,the resistance exercise program was constructed through literature analysis and expert meeting method,and the feasibility of the program was confirmed through pre-experiments.The patients undergoing radical gastrectomy in the Department of Gastric Surgery of a tertiary hospital in Zhejiang province were selected as the study subjects by convenience sampling method,with 36 patients from November to December 2023 as the control group and 36 patients from January to March 2024 as the experimental group,and the intervention continued for 7 days.The experimental group received a resistance exercise program on the basis of conventional rapid recovery surgical care,and the control group received routine rapid recovery surgical care.On the first day before surgery,the 3rd postoperative day,and the 7th postoperative day,the Anderson Symptom Assessment Scale-Gastrointestinal Tumor-Specific Module Scale and the Functional Assessment of Cancer Therapy-General were used for evaluation.Results During the application of the program,a case was excluded from the experimental group,and a case was excluded from the control group.Ultimately,70 patients were included.The results of generalized estimating equation showed that there was an interaction effect between the 2 groups in the surgery-related symptom cluster and the energy deficiency symptom cluster(P＜0.05).Simple effect analysis showed that on the 7th day after surgery,the scores of the surgery-related symptom cluster in the experimental group and the control group were 3(1,5)and 5(3,9)respectively,and the scores of the energy deficiency symptom cluster were 6(8,18)and 14(8,19)respectively,with statistically significant differences(P＜0.05).The quality of life scores of the experimental group and the control group were(82.06±9.89)and(73.86±13.08)respectively,with statistically significant differences(P=0.004).No adverse events occurred in either group.Conclusion The resistance exercise program is scientific,safe and feasible,which can improve the surgery-related symptoms and energy deficiency symptoms,and improve the quality of life of patients with gastric cancer after surgery.

Objective:To analyze the correlation between metabolic syndrome indexes and thyroid nodules in individuals receiving health examinations.Methods:It′s a retrospective cohort study. A total of 2 678 individuals who received health examinations in the Health Management Center of the First Hospital of Shanxi Medical University for four consecutive years and met the admission criteria were selected as the research objects. According to the metabolic syndrome index data of health examination, according to the different duration of metabolic syndrome during the observation period, the group-based trajectory model, Bayesian information criterion and average posterior grouping probability were used to determine the best trajectory groups, and the objects were divided into three different metabolic syndrome index trajectory groups: normal, abnormal and recovery group. During the physical examination in 2022 and 2023, the detection of thyroid nodules in each group was followed up, and the difference of detection rate of thyroid nodules in different metabolic syndrome trajectory groups was compared by Log-rank test, and the correlation between different metabolic syndrome index change trajectories and thyroid nodules was analyzed by logistic regression model.Results:The cumulative detection rate of thyroid nodules in normal group, abnormal group and recovery group was 18.8% (77/410), 27.5% (327/1 190) and 24.7% (266/1 078), respectively ( χ2=19.482, P<0.001). In model 4, after adjusting for age, gender, smoking, drinking, staying up late, insomnia, physical activity, family history and other confounding factors, the risk of thyroid nodules in abnormal group and recovery group was still 2.011 times (95% CI: 1.457-2.776) and 2.006 times (95% CI: 1.389-2.897) of that in normal group. Conclusion:There is a positive correlation between metabolic syndrome index and thyroid nodules in individuals receiving health examinations, and metabolic syndrome index can be used as a predictive index of thyroid nodules.

Objective:To evaluate the application effect of intelligent management of health management (examination) institutions in Shanxi Province.Methods:In this study, a cross-sectional study was adopted. In October 2023, through convenient sampling, 300 health management (examination) institutions in Shanxi Province were investigated according to the four regions of northern Shanxi, central Shanxi, southern Shanxi and southeastern Shanxi, and the application information of intelligent management in the whole process from January to December 2022 was collected. According to the evaluation indicators in the documents of the National Health and Wellness Commission, six indicators were analyzed, including the completion rate of health questionnaire, the integrity of physical examination files, the filing rate of physical examination cycle, the evaluation rate of cardiovascular risk diseases, the re-examination rate of patients with chronic diseases (blood pressure, blood lipid and blood glucose indicators) and the follow-up rate of important abnormal results.Results:The completion rates of health questionnaires in northern Shanxi, central Shanxi, southern Shanxi and southeastern Shanxi were 54.9%, 84.2%, 93.2% and 98.2% ( χ 2=225 050.17, P<0.001), and the filing rates of health checkups in various regions were 89.1%, 94.7%, 94.0% and 94.5% ( χ 2=10 254.02, P<0.001). The filing rates of physical examination cycles in each region were 21.8%, 23.4%, 24.3% and 24.7% ( χ 2=734.15, P<0.001), and the assessment rates of cardiovascular risk diseases in each region were 84.5%, 85.4%, 80.2% and 86.2% ( χ 2=4 627.99, P<0.001). The reexamination rates of patients with chronic diseases (blood pressure, blood lipid and blood glucose indicators) in different regions were 38.8%, 39.7%, 39.3% and 39.5% ( χ 2=24.24, P<0.001), and the follow-up rates of important abnormal results were 81.7%, 84.1%, 82.9% and 83.9% ( χ 2=255.02, P<0.001). Conclusion:Shanxi health management (examination) institutions have achieved certain results in the application of intelligent management in the whole process, but there is still much room for improvement in the filing of physical examination cycle and re-examination of chronic diseases.

OBJECTIVE To understand the current status of prevention and control of traditional Chinese medicine(TCM)diagnosis and treatment technique-related infections in various grades of hospitals in Jiangsu Province so as to provide bases for management departments to put forward the norms.METHODS The questionnaire was de-signed by the methods such as Delphic correspondence,the current status of prevalence,prevention and control of TCM diagnosis and treatment technique-related infections among the health care workers in the hospitals of Jiang-su Province was investigated by using convenience sampling method.RESULTS A total of 508 questionnaires were collected from 13 cities of Jiangsu Province.The results showed that the TCM treatment room(63.64％)was the most common operation site for minimally invasive TCM diagnosis and treatment techniques,the bedside(62.50％)of the patients was the major operation site for Chinese medicine enema,and the central sterile supply department(55.31％)was the preferred choice of cleaning and disinfection site for daily recycled TCM apparatu-ses.'One person used for once,airing and preparing for later use after cleaning and disinfection for once'was the major approach taken for the cleaning and disinfection of Gua Sha boards(82.45％)and TCM pots(87.50％).67.87％of the health care workers said that they wound cleaned and disinfected the medical apparatuses of dress-ing,ironing and fumigation every time after the use.The natural ventilation and ultraviolet light(50.39％)was the major method that was taken for the ventilation and disinfection of the treatment rooms for TCM operations.Quick-drying hand disinfectant and non-touch hand-washing equipment(39.37％)were the most commonly e-quipped hand hygiene facilities.CONCLUSIONS The prevention and control of TCM diagnosis and treatment tech-nique-related infections and the health care workers' capabilities for prevention and control of the infection have made remarkable progress in the various grades of hospitals in Jiangsu Province.However,there is still room for further improvement,and the standardized management and construction should be completed so as to safeguard the TCM diagnosis and treatment techniques.

OBJECTIVE To understand the current status of prevention and control of traditional Chinese medicine(TCM)diagnosis and treatment technique-related infections in various grades of hospitals in Jiangsu Province so as to provide bases for management departments to put forward the norms.METHODS The questionnaire was de-signed by the methods such as Delphic correspondence,the current status of prevalence,prevention and control of TCM diagnosis and treatment technique-related infections among the health care workers in the hospitals of Jiang-su Province was investigated by using convenience sampling method.RESULTS A total of 508 questionnaires were collected from 13 cities of Jiangsu Province.The results showed that the TCM treatment room(63.64％)was the most common operation site for minimally invasive TCM diagnosis and treatment techniques,the bedside(62.50％)of the patients was the major operation site for Chinese medicine enema,and the central sterile supply department(55.31％)was the preferred choice of cleaning and disinfection site for daily recycled TCM apparatu-ses.'One person used for once,airing and preparing for later use after cleaning and disinfection for once'was the major approach taken for the cleaning and disinfection of Gua Sha boards(82.45％)and TCM pots(87.50％).67.87％of the health care workers said that they wound cleaned and disinfected the medical apparatuses of dress-ing,ironing and fumigation every time after the use.The natural ventilation and ultraviolet light(50.39％)was the major method that was taken for the ventilation and disinfection of the treatment rooms for TCM operations.Quick-drying hand disinfectant and non-touch hand-washing equipment(39.37％)were the most commonly e-quipped hand hygiene facilities.CONCLUSIONS The prevention and control of TCM diagnosis and treatment tech-nique-related infections and the health care workers' capabilities for prevention and control of the infection have made remarkable progress in the various grades of hospitals in Jiangsu Province.However,there is still room for further improvement,and the standardized management and construction should be completed so as to safeguard the TCM diagnosis and treatment techniques.

Objective To construct a postoperative resistance exercise program for patients with gastric cancer,and to explore its intervention effect on symptom clusters and quality of life.Methods Based on the interactive attainment theory,the resistance exercise program was constructed through literature analysis and expert meeting method,and the feasibility of the program was confirmed through pre-experiments.The patients undergoing radical gastrectomy in the Department of Gastric Surgery of a tertiary hospital in Zhejiang province were selected as the study subjects by convenience sampling method,with 36 patients from November to December 2023 as the control group and 36 patients from January to March 2024 as the experimental group,and the intervention continued for 7 days.The experimental group received a resistance exercise program on the basis of conventional rapid recovery surgical care,and the control group received routine rapid recovery surgical care.On the first day before surgery,the 3rd postoperative day,and the 7th postoperative day,the Anderson Symptom Assessment Scale-Gastrointestinal Tumor-Specific Module Scale and the Functional Assessment of Cancer Therapy-General were used for evaluation.Results During the application of the program,a case was excluded from the experimental group,and a case was excluded from the control group.Ultimately,70 patients were included.The results of generalized estimating equation showed that there was an interaction effect between the 2 groups in the surgery-related symptom cluster and the energy deficiency symptom cluster(P＜0.05).Simple effect analysis showed that on the 7th day after surgery,the scores of the surgery-related symptom cluster in the experimental group and the control group were 3(1,5)and 5(3,9)respectively,and the scores of the energy deficiency symptom cluster were 6(8,18)and 14(8,19)respectively,with statistically significant differences(P＜0.05).The quality of life scores of the experimental group and the control group were(82.06±9.89)and(73.86±13.08)respectively,with statistically significant differences(P=0.004).No adverse events occurred in either group.Conclusion The resistance exercise program is scientific,safe and feasible,which can improve the surgery-related symptoms and energy deficiency symptoms,and improve the quality of life of patients with gastric cancer after surgery.

Objective:To analyze the correlation between metabolic syndrome indexes and thyroid nodules in individuals receiving health examinations.Methods:It′s a retrospective cohort study. A total of 2 678 individuals who received health examinations in the Health Management Center of the First Hospital of Shanxi Medical University for four consecutive years and met the admission criteria were selected as the research objects. According to the metabolic syndrome index data of health examination, according to the different duration of metabolic syndrome during the observation period, the group-based trajectory model, Bayesian information criterion and average posterior grouping probability were used to determine the best trajectory groups, and the objects were divided into three different metabolic syndrome index trajectory groups: normal, abnormal and recovery group. During the physical examination in 2022 and 2023, the detection of thyroid nodules in each group was followed up, and the difference of detection rate of thyroid nodules in different metabolic syndrome trajectory groups was compared by Log-rank test, and the correlation between different metabolic syndrome index change trajectories and thyroid nodules was analyzed by logistic regression model.Results:The cumulative detection rate of thyroid nodules in normal group, abnormal group and recovery group was 18.8% (77/410), 27.5% (327/1 190) and 24.7% (266/1 078), respectively ( χ2=19.482, P<0.001). In model 4, after adjusting for age, gender, smoking, drinking, staying up late, insomnia, physical activity, family history and other confounding factors, the risk of thyroid nodules in abnormal group and recovery group was still 2.011 times (95% CI: 1.457-2.776) and 2.006 times (95% CI: 1.389-2.897) of that in normal group. Conclusion:There is a positive correlation between metabolic syndrome index and thyroid nodules in individuals receiving health examinations, and metabolic syndrome index can be used as a predictive index of thyroid nodules.

Objective:To evaluate the application effect of intelligent management of health management (examination) institutions in Shanxi Province.Methods:In this study, a cross-sectional study was adopted. In October 2023, through convenient sampling, 300 health management (examination) institutions in Shanxi Province were investigated according to the four regions of northern Shanxi, central Shanxi, southern Shanxi and southeastern Shanxi, and the application information of intelligent management in the whole process from January to December 2022 was collected. According to the evaluation indicators in the documents of the National Health and Wellness Commission, six indicators were analyzed, including the completion rate of health questionnaire, the integrity of physical examination files, the filing rate of physical examination cycle, the evaluation rate of cardiovascular risk diseases, the re-examination rate of patients with chronic diseases (blood pressure, blood lipid and blood glucose indicators) and the follow-up rate of important abnormal results.Results:The completion rates of health questionnaires in northern Shanxi, central Shanxi, southern Shanxi and southeastern Shanxi were 54.9%, 84.2%, 93.2% and 98.2% ( χ 2=225 050.17, P<0.001), and the filing rates of health checkups in various regions were 89.1%, 94.7%, 94.0% and 94.5% ( χ 2=10 254.02, P<0.001). The filing rates of physical examination cycles in each region were 21.8%, 23.4%, 24.3% and 24.7% ( χ 2=734.15, P<0.001), and the assessment rates of cardiovascular risk diseases in each region were 84.5%, 85.4%, 80.2% and 86.2% ( χ 2=4 627.99, P<0.001). The reexamination rates of patients with chronic diseases (blood pressure, blood lipid and blood glucose indicators) in different regions were 38.8%, 39.7%, 39.3% and 39.5% ( χ 2=24.24, P<0.001), and the follow-up rates of important abnormal results were 81.7%, 84.1%, 82.9% and 83.9% ( χ 2=255.02, P<0.001). Conclusion:Shanxi health management (examination) institutions have achieved certain results in the application of intelligent management in the whole process, but there is still much room for improvement in the filing of physical examination cycle and re-examination of chronic diseases.

OBJECTIVE To improve the efficiency and quality of dispensed oral drug management in the inpatient pharmacy,and ensure the safety of drug use in patients.METHODS SWOT(strength,weakness,opportunity,threat)analysis method was used to analyze the internal strengths and weaknesses,as well as the external opportunities and threats in the construction of a closed-loop management system for dispensed oral drugs in the inpatient pharmacy of our hospital,and propose improvement strategies.RESULTS&CONCLUSIONS A refined,full-process,closed-loop traceability management system for dispensed oral drugs in the inpatient pharmacies was successfully established,which is traceable in origin,trackable in destination,and accountable in responsibility.After the application of this system,the registration rate of dispensed drug information and the correctness rate of registration content both reached 100%.The proportion of overdue drug varieties in the same period of 2024 decreased by 77.78%compared to March 2020,the inventory volume decreased by 29.50%compared to the first quarter of 2020,the per-bed medication volume decreased by 32.14%compared to the first quarter of 2020;the average workload per post in the same period of 2023 increased by 49.09%compared to 2019,the dispensing accuracy rate reached 100%,and the improvement rate of quality control problem increased by 25.25%compared to 2021.This system effectively improves the safety and accuracy of dispensed oral drug management in the inpatient pharmacy.

OBJECTIVE To analyze the impurities in cetirizine hydrochloride oral solution, and explore the existing problems of the production process, and provide a reference for improvement of the product quality. METHODS The related substances of 3 manufactures’ cetirizine hydrochloride oral solution were determined by HPLC. The main impurities were studied qualitively and quantitatively. The chromatographic separation was performed on a CAPCELL PAK C18 (4.6 mm×250 mm, 5 μm) column with a mixture of acetonitrile-water(17 : 83)(phosphoric acid adjusted to pH 1.5) and acetonitrile-water(35 : 65)(phosphoric acid adjusted to pH 1.5) as mobile phase by gradient elution. Detection wavelength was set at 230 nm. The confirmatory structure of the main impurities was determined by chromatography-mass spectrometry, the compatibility test between raw materials and pharmaceutical excipients was established to determine the pathway of impurities. The chromatographic separation was performed on an ACQUITY UPLC HSS-C18(150 mm×2.1 mm, 1.7 μm) column with 20 mmol·L–1 ammonium acetate(with 0.1% acetic acid)-methanol as mobile phase by gradient elution. RESULTS There might be 5 impurities in cetirizine hydrochloride oral solution. The two main related substances detected in cetirizine hydrochloride oral solution from 3 enterprises were cetirizine propylene glycol esters(a pair of diastereomers) and cetirizine glycerides(a pair of diastereomers). The emergence of impurities was highly relater to the formulation process. CONCLUSION The formulation technology of cetirizine hydrochloride oral solution need to be improved, and the active ingredients are incompatible with excipients. The related substances of cetirizine hydrochloride oral solution should be controlled from formulation design to improve the quality.