Objective:To explore the application effect of trans-theoretical model combined with ABC emotion management mode in patients with type D personality coronary heart disease.Methods:Using the convenient sampling method, patients with type D personality coronary heart disease who were hospitalized in the Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University from May 2018 to May 2020 were selected as the research subjects. Patients admitted from May 2018 to May 2019 were selected as the control group ( n=50) , while patients admitted from June 2019 to May 2020 were selected as the observation group ( n=50) . The control group received conventional ABC emotion management mode, while the observation group received trans-theoretical model combined with ABC emotion management mode. The effect of the intervention was evaluated by Automatic Thoughts Questionnaire (ATQ) , the Exercise of Self-Care Agency Scale (ESCA) and Seattle Angina Questionnaire (SAQ) . Results:Before intervention, there was no statistically significant difference in ATQ, ESCA and SA scores between the two groups ( P>0.05) . After the intervention, the ATQ scores of the two groups were decreased and the score of the observation group was lower than those of the control group, and the differences were statistically significant ( P<0.01) . After the intervention, the ESCA and SAQ scores of the two groups were improved and scores of the observation group were higher than those of the control group, and the differences were statistically significant ( P<0.01) . Conclusions:The implementation of trans-theoretical model combined with ABC emotion management model for patients with type D personality coronary heart disease can eliminate negative thinking of patients, improve their self-care ability and improve their quality of life, which is worthy of clinical promotion and application.

OBJECTIVE: To assess the value of copy number variation analysis based on next generation sequencing (CNV-seq) in prenatal diagnosis for women at advanced maternal age. METHODS: A prospective analysis was carried out for women who underwent amniocentesis at 18~36 weeks of gestation for fetal CNV-seq for advanced maternal age. RESULTS: For 1461 unrelated Chinese women with a singleton pregnancy, CNV-seq was performed for all samples successfully. The proportion of chromosomal abnormalities was 2.3% (34/1461), of which 44.12% were submicroscopic copy number variations (<5 Mb). CONCLUSION Pregnant women at an advanced maternal age should be informed for not only common trisomies but all pathogenic chromosomal aberrations. NGS was a sensitive and accurate approach for detecting CNVs.
Chromosome Aberrations ; Chromosome Disorders ; DNA Copy Number Variations ; Female ; Humans ; Maternal Age ; Pregnancy ; Prenatal Diagnosis ; Prospective Studies