Objective To evaluate the clinical efficacy and safety of topical Zhikang Capsules(composed of Rhei Radix et Rhizoma,Coptidis Rhizoma,Notoginseng Radix et Rhizoma,Angelicae Dahuricae Radix,Asini Corii Colla,calcined Os Draconis,Bletillae Rhizoma,Myrrha,Endoconcha Sepiae,Rubia Radix et Rhizomae,Resina Draconis,etc.)in treating patients with risk of bleeding after operation for high perianal abscess.Methods The observation was conducted in 120 patients who took long-term oral use of Aspirin Enteric-Coated Tablets due to suffering from chronic stable angina and underwent operation for high perianal abscess in The Second Affiliated Hospital of Kunming Medical University from January 2024 to December 2024.The patients were divided into a control group and a treatment group using a randomized number table,with 60 cases in each group.The control group received postoperative topical Batracimab,while the treatment group received topical Zhikang Capsules.Both groups underwent a 7-day treatment course.Changes in the wound bleeding scores on postoperative days 2,4,and 6 in the two groups were observed.The scores of anal pain,perianal congestion and swelling,and wound exudate on postoperative day 5 were compared between the two groups.After treatment,the safety of both regimens was evaluated.Results(1)Scores of wound bleeding in both groups were decreased significantly on postoperative day 4 compared to postoperative day 2(P＜0.05 or P＜0.01),and were further decreased on postoperative day 6 compared to postoperative day 4(P＜0.01).However,no significant differences were observed between the two groups on postoperative days 2,4,or 6(P＞0.05).(2)The treatment group exhibited significantly lower scores of anal pain,perianal congestion and swelling,and wound exudate than the control group on postoperative day 5(P＜0.05 or P＜0.01).(3)The mean time for would healing in the treatment group was(16.821±1.793)days,significantly shorter than that in the control group(18.114±2.632)days,and the difference was significant(P＜0.05).(4)No significant adverse reactions occurred in either group during treatment,indicating a high safety profile.Conclusion Topical Zhikang Capsules demonstrate definite therapeutic efficacy and safety for patients complicated with risk of bleeding after operation for high perianal abscess,and exert stronger effects than Batracimab on alleviating anal pain,perianal swelling and wound exudate,and on accelerating wound healing.