Depression is a common mental disorder with adverse effects on human health and quality of life.Although its pathogenesis remains unclear,numerous recent studies have indicated a close association between depression and mitochondrial dysfunction.This review explores the critical role of mitochondrial dysfunction in the pathogenesis of depression from the aspects of energy metabolism disorders,oxidative stress and inflammatory responses,mitochondrial DNA damage and mutations,and the imbalance of the mitochondrial quality control systems.We also summarize recent advances in the use of traditional Chinese medicine(TCM)to treat depression by regulating mitochondrial function.The findings show the potential of TCM in enhancing mitochondrial energy metabolism,reducing oxidative stress and inflammatory responses,improving mitochondrial DNA,and modulating the mitochondrial quality control systems,including for the in-depth study of the pathogenesis of depression and its treatment with TCM.

Depression is a common mental disorder with adverse effects on human health and quality of life.Although its pathogenesis remains unclear,numerous recent studies have indicated a close association between depression and mitochondrial dysfunction.This review explores the critical role of mitochondrial dysfunction in the pathogenesis of depression from the aspects of energy metabolism disorders,oxidative stress and inflammatory responses,mitochondrial DNA damage and mutations,and the imbalance of the mitochondrial quality control systems.We also summarize recent advances in the use of traditional Chinese medicine(TCM)to treat depression by regulating mitochondrial function.The findings show the potential of TCM in enhancing mitochondrial energy metabolism,reducing oxidative stress and inflammatory responses,improving mitochondrial DNA,and modulating the mitochondrial quality control systems,including for the in-depth study of the pathogenesis of depression and its treatment with TCM.

Objective To observe the effect of interactive somatic game Kinect on motor of lower limbs and balance function in patients with stroke. Methods 40 inpatients were divided into experimental group (n=20) and control group (n=20). All the patients received routine rehabilitations, while the experimental group received the interactive game Kinect in addition. They were assessed with Fugl-Meyer assessment of lower limb (FMA) and Berg balance scale (BBS) before and after intervention. Results The scores of flexor synergy, extensor synergy,movement combining synergies (in sitting), lower limb total score of FMA, and the score of BBS increased more in the experimental group than in the control group (P<0.05) after intervention. Conclusion The interactive somatic game Kinect can further improve the motor of lower limb and balance function of patients with stroke.