Gastric cancer is one of the most common cancers in both Korea and worldwide. Since 2004, the Korean Practice Guidelines for Gastric Cancer have been regularly updated, with the 4th edition published in 2022. The 4th edition was the result of a collaborative work by an interdisciplinary team, including experts in gastric surgery, gastroenterology, endoscopy, medical oncology, abdominal radiology, pathology, nuclear medicine, radiation oncology, and guideline development methodology. The current guideline is the 5th version, an updated version of the 4th edition. In this guideline, 6 key questions (KQs) were updated or proposed after a collaborative review by the working group, and 7 statements were developed, or revised, or discussed based on a systematic review using the MEDLINE, Embase, Cochrane Library, and KoreaMed database. Over the past 2 years, there have been significant changes in systemic treatment, leading to major updates and revisions focused on this area.Additionally, minor modifications have been made in other sections, incorporating recent research findings. The level of evidence and grading of recommendations were categorized according to the Grading of Recommendations, Assessment, Development and Evaluation system. Key factors for recommendation included the level of evidence, benefit, harm, and clinical applicability. The working group reviewed and discussed the recommendations to reach a consensus. The structure of this guideline remains similar to the 2022 version.Earlier sections cover general considerations, such as screening, diagnosis, and staging of endoscopy, pathology, radiology, and nuclear medicine. In the latter sections, statements are provided for each KQ based on clinical evidence, with flowcharts supporting these statements through meta-analysis and references. This multidisciplinary, evidence-based gastric cancer guideline aims to support clinicians in providing optimal care for gastric cancer patients.

Gastric cancer is one of the most common cancers in both Korea and worldwide. Since 2004, the Korean Practice Guidelines for Gastric Cancer have been regularly updated, with the 4th edition published in 2022. The 4th edition was the result of a collaborative work by an interdisciplinary team, including experts in gastric surgery, gastroenterology, endoscopy, medical oncology, abdominal radiology, pathology, nuclear medicine, radiation oncology, and guideline development methodology. The current guideline is the 5th version, an updated version of the 4th edition. In this guideline, 6 key questions (KQs) were updated or proposed after a collaborative review by the working group, and 7 statements were developed, or revised, or discussed based on a systematic review using the MEDLINE, Embase, Cochrane Library, and KoreaMed database. Over the past 2 years, there have been significant changes in systemic treatment, leading to major updates and revisions focused on this area.Additionally, minor modifications have been made in other sections, incorporating recent research findings. The level of evidence and grading of recommendations were categorized according to the Grading of Recommendations, Assessment, Development and Evaluation system. Key factors for recommendation included the level of evidence, benefit, harm, and clinical applicability. The working group reviewed and discussed the recommendations to reach a consensus. The structure of this guideline remains similar to the 2022 version.Earlier sections cover general considerations, such as screening, diagnosis, and staging of endoscopy, pathology, radiology, and nuclear medicine. In the latter sections, statements are provided for each KQ based on clinical evidence, with flowcharts supporting these statements through meta-analysis and references. This multidisciplinary, evidence-based gastric cancer guideline aims to support clinicians in providing optimal care for gastric cancer patients.

Gastric cancer is one of the most common cancers in both Korea and worldwide. Since 2004, the Korean Practice Guidelines for Gastric Cancer have been regularly updated, with the 4th edition published in 2022. The 4th edition was the result of a collaborative work by an interdisciplinary team, including experts in gastric surgery, gastroenterology, endoscopy, medical oncology, abdominal radiology, pathology, nuclear medicine, radiation oncology, and guideline development methodology. The current guideline is the 5th version, an updated version of the 4th edition. In this guideline, 6 key questions (KQs) were updated or proposed after a collaborative review by the working group, and 7 statements were developed, or revised, or discussed based on a systematic review using the MEDLINE, Embase, Cochrane Library, and KoreaMed database. Over the past 2 years, there have been significant changes in systemic treatment, leading to major updates and revisions focused on this area.Additionally, minor modifications have been made in other sections, incorporating recent research findings. The level of evidence and grading of recommendations were categorized according to the Grading of Recommendations, Assessment, Development and Evaluation system. Key factors for recommendation included the level of evidence, benefit, harm, and clinical applicability. The working group reviewed and discussed the recommendations to reach a consensus. The structure of this guideline remains similar to the 2022 version.Earlier sections cover general considerations, such as screening, diagnosis, and staging of endoscopy, pathology, radiology, and nuclear medicine. In the latter sections, statements are provided for each KQ based on clinical evidence, with flowcharts supporting these statements through meta-analysis and references. This multidisciplinary, evidence-based gastric cancer guideline aims to support clinicians in providing optimal care for gastric cancer patients.

Background: Understanding the virulence and pathogenicity of invasive nontyphoidal Salmonella (iNTS) in children may support timely treatment and enable closer monitoring of chronic infections. iNTS epidemiology in Asia remains inadequately described. We analyzed the genetic diversity and virulence genes associated with extra-intestinal invasion in Korean children. Methods: Salmonella isolates from children < 18 yrs of age diagnosed with moderate-tosevere salmonellosis between January 2019 and December 2021 were subjected to antibiotic susceptibility testing and whole-genome sequencing. Results: In total, 58 cases were included. We identified 20 serotypes, the most prevalent being Salmonella Enteritidis (N = 21), followed by Infantis (N = 6), I 4,[5],12:i:- (N = 5), and Bareilly (N = 5). Extra-intestinal invasion occurred in 12 (20.7%) cases involving Salmonella Oranienburg (2/2), Give (1/1), Javiana (1/1), Paratyphi B var. L(+) tartrate+ (1/1), Schwarzengrund (1/1), Singapore (1/1), Montevideo (1/2), Saintpaul (1/2), I 4:b:- (1/2), Infantis (1/6), and Enteritidis (1/21). While the numbers of total virulence genes and genes belonging to major virulence categories did not significantly differ between iNTS and noniNTS, several genetic factors, including Salmonella pathogenicity island (SPI)-1 (P = 0.039), SPI-2 (P = 0.020), SPI-5 (P = 0.014), SPI-13 (P = 0.010), cytolethal distending toxin-related genes (P = 1.4 × 10 –4 ), fepC (P = 0.021), and tcpC (P = 0.040) were more frequent in invasive isolates. Conclusions Salmonella Enteritidis-ST11 predominated in infections among Korean children, but invasive isolates were rare. Early detection of genetic factors associated with extra-intestinal invasion will be helpful for prompt and appropriate treatment.

Background and Objectives: Post-thyroidectomy hematoma is reported in about 0.7%- 2.1% of patients who underwent thyroidectomy. A drain is frequently placed after surgery to prevent swelling and hematoma. This study aims to compare clinical differences and postoperative complications depending on the presence or absence of a drain, and to identify the factors affecting hematoma after thyroidectomy.Subjects and Method This is a retrospective study of patients who underwent conventional thyroidectomy from March 2019 to Jun 2023. We examined patient’s age, gender, underlying diseases, use of antithrombotic drug, surgery type, thyroid volume, length of hospital stay and postoperative complications (hematoma and vocal cord palsy) by examining medical records. Results: Of 587 patients enrolled in the study, the drain was placed in 369 (62.9%) patients, and not in 218 (37.1%) patients. The mean age, incidence of hypertension and Grave’s disease comorbidity, antithrombotic drug use, number of patients who underwent neck dissection, thyroid volume, operating time, and length of hospital stay were significantly higher in the drain placed group (p<0.05). But there was no significant difference in the ratio of vocal cord palsy and hematoma occurrence between the two groups. In logistic regression analysis, diabetes, the use of antithrombotic drugs, neck dissection, and larger thyroid volume were identified as risk factors for the occurrence of hematoma (p<0.05). Conclusion Surgeons tended to place the drain in patients with high bleeding tendency after thyroidectomy, but there was no difference in the incidence of hematoma according to drain placement. Rather, patients’ length of hospital stay increased due to the placement of drain.

Background and Objectives: Post-thyroidectomy hematoma is reported in about 0.7%- 2.1% of patients who underwent thyroidectomy. A drain is frequently placed after surgery to prevent swelling and hematoma. This study aims to compare clinical differences and postoperative complications depending on the presence or absence of a drain, and to identify the factors affecting hematoma after thyroidectomy.Subjects and Method This is a retrospective study of patients who underwent conventional thyroidectomy from March 2019 to Jun 2023. We examined patient’s age, gender, underlying diseases, use of antithrombotic drug, surgery type, thyroid volume, length of hospital stay and postoperative complications (hematoma and vocal cord palsy) by examining medical records. Results: Of 587 patients enrolled in the study, the drain was placed in 369 (62.9%) patients, and not in 218 (37.1%) patients. The mean age, incidence of hypertension and Grave’s disease comorbidity, antithrombotic drug use, number of patients who underwent neck dissection, thyroid volume, operating time, and length of hospital stay were significantly higher in the drain placed group (p<0.05). But there was no significant difference in the ratio of vocal cord palsy and hematoma occurrence between the two groups. In logistic regression analysis, diabetes, the use of antithrombotic drugs, neck dissection, and larger thyroid volume were identified as risk factors for the occurrence of hematoma (p<0.05). Conclusion Surgeons tended to place the drain in patients with high bleeding tendency after thyroidectomy, but there was no difference in the incidence of hematoma according to drain placement. Rather, patients’ length of hospital stay increased due to the placement of drain.

Background: Chronic cough is a common symptom encountered by healthcare practitioners.The global prevalence of chronic cough is 9.6%, with a female predominance. The aim of our study is to reveal the sex differences in prevalence and severity of chronic cough in South Korea, stratified by age and etiology. Methods: This study included adult patients with chronic cough who were recruited from 19 respiratory centers in South Korea. Patients completed the cough numeric rating scale (NRS) and COugh Assessment Test (COAT) questionnaire to assess the severity and multidimensional impact of cough. Results: Among the 625 patients, 419 (67.0%) were females, with a male-to-female ratio of 1:2.03. The mean age was 49.4 years, and the median duration of cough was 12 weeks. The mean NRS and COAT scores were 5.5 ± 1.8 and 9.5 ± 3.6, respectively. Female patients were older (45.3 ± 15.4 vs. 51.6 ± 15.2, P < 0.001) and more likely to have asthma/cough variant asthma (CVA) (26.7% vs. 40.8%, P = 0.001) than male patients. There was no difference in the duration or severity of cough between sexes, regardless of the cause. The male-tofemale ratio was lower for upper airway cough syndrome (UACS), asthma/CVA, and gastroesophageal reflux disease (GERD), but not for eosinophilic bronchitis (EB) or unexplained cough. The mean age of female patients was higher in UACS and asthma/CVA, but not in EB, GERD, or unexplained cough. The majority (24.2%) fell within the age category of 50s. The proportion of females with cough increased with age, with a significant rise in the 50s, 60s, and 70–89 age groups. The severity of cough decreased in the 50s, 60s, and 70–89 age groups, with no significant sex differences within the same age group. Conclusion The sex disparities in prevalence and severity of cough varied significantly depending on the age category and etiology. Understanding the specific sex-based difference could enhance comprehension of cough-related pathophysiology and treatment strategies.

Background and Objectives: Post-thyroidectomy hematoma is reported in about 0.7%- 2.1% of patients who underwent thyroidectomy. A drain is frequently placed after surgery to prevent swelling and hematoma. This study aims to compare clinical differences and postoperative complications depending on the presence or absence of a drain, and to identify the factors affecting hematoma after thyroidectomy.Subjects and Method This is a retrospective study of patients who underwent conventional thyroidectomy from March 2019 to Jun 2023. We examined patient’s age, gender, underlying diseases, use of antithrombotic drug, surgery type, thyroid volume, length of hospital stay and postoperative complications (hematoma and vocal cord palsy) by examining medical records. Results: Of 587 patients enrolled in the study, the drain was placed in 369 (62.9%) patients, and not in 218 (37.1%) patients. The mean age, incidence of hypertension and Grave’s disease comorbidity, antithrombotic drug use, number of patients who underwent neck dissection, thyroid volume, operating time, and length of hospital stay were significantly higher in the drain placed group (p<0.05). But there was no significant difference in the ratio of vocal cord palsy and hematoma occurrence between the two groups. In logistic regression analysis, diabetes, the use of antithrombotic drugs, neck dissection, and larger thyroid volume were identified as risk factors for the occurrence of hematoma (p<0.05). Conclusion Surgeons tended to place the drain in patients with high bleeding tendency after thyroidectomy, but there was no difference in the incidence of hematoma according to drain placement. Rather, patients’ length of hospital stay increased due to the placement of drain.

Background and Objectives: Post-thyroidectomy hematoma is reported in about 0.7%- 2.1% of patients who underwent thyroidectomy. A drain is frequently placed after surgery to prevent swelling and hematoma. This study aims to compare clinical differences and postoperative complications depending on the presence or absence of a drain, and to identify the factors affecting hematoma after thyroidectomy.Subjects and Method This is a retrospective study of patients who underwent conventional thyroidectomy from March 2019 to Jun 2023. We examined patient’s age, gender, underlying diseases, use of antithrombotic drug, surgery type, thyroid volume, length of hospital stay and postoperative complications (hematoma and vocal cord palsy) by examining medical records. Results: Of 587 patients enrolled in the study, the drain was placed in 369 (62.9%) patients, and not in 218 (37.1%) patients. The mean age, incidence of hypertension and Grave’s disease comorbidity, antithrombotic drug use, number of patients who underwent neck dissection, thyroid volume, operating time, and length of hospital stay were significantly higher in the drain placed group (p<0.05). But there was no significant difference in the ratio of vocal cord palsy and hematoma occurrence between the two groups. In logistic regression analysis, diabetes, the use of antithrombotic drugs, neck dissection, and larger thyroid volume were identified as risk factors for the occurrence of hematoma (p<0.05). Conclusion Surgeons tended to place the drain in patients with high bleeding tendency after thyroidectomy, but there was no difference in the incidence of hematoma according to drain placement. Rather, patients’ length of hospital stay increased due to the placement of drain.

Background and Objectives: Post-thyroidectomy hematoma is reported in about 0.7%- 2.1% of patients who underwent thyroidectomy. A drain is frequently placed after surgery to prevent swelling and hematoma. This study aims to compare clinical differences and postoperative complications depending on the presence or absence of a drain, and to identify the factors affecting hematoma after thyroidectomy.Subjects and Method This is a retrospective study of patients who underwent conventional thyroidectomy from March 2019 to Jun 2023. We examined patient’s age, gender, underlying diseases, use of antithrombotic drug, surgery type, thyroid volume, length of hospital stay and postoperative complications (hematoma and vocal cord palsy) by examining medical records. Results: Of 587 patients enrolled in the study, the drain was placed in 369 (62.9%) patients, and not in 218 (37.1%) patients. The mean age, incidence of hypertension and Grave’s disease comorbidity, antithrombotic drug use, number of patients who underwent neck dissection, thyroid volume, operating time, and length of hospital stay were significantly higher in the drain placed group (p<0.05). But there was no significant difference in the ratio of vocal cord palsy and hematoma occurrence between the two groups. In logistic regression analysis, diabetes, the use of antithrombotic drugs, neck dissection, and larger thyroid volume were identified as risk factors for the occurrence of hematoma (p<0.05). Conclusion Surgeons tended to place the drain in patients with high bleeding tendency after thyroidectomy, but there was no difference in the incidence of hematoma according to drain placement. Rather, patients’ length of hospital stay increased due to the placement of drain.