Background: The heterogeneity of chronic kidney disease (CKD) and fragmented analysis methods hinder the precise identification of novel biomarkers. We addressed this challenge using two independent cohorts to integrate genomics and metabolomics, aiming to identify cause-specific biomarkers for CKD in the Korean population. Methods: A longitudinal genome-wide association study using the Cox proportional hazards model was conducted using the Ansan and Ansung cohort. To validate these genomic biomarkers and integrate them with plasma metabolomics biomarkers, we utilized a hospital-based biopsy cohort to identify cause-specific CKD biomarkers. Within the biopsy cohort, we analyzed four disease subsets, including type 2 diabetic kidney disease (DKD), hypertensive nephropathy (HN), immunoglobulin A nephropathy (IgAN), and membranous nephropathy (MN), and compared them with healthy individuals. Significant single nucleotide polymorphisms(SNPs) and metabolites for each CKD subset were identified through logistic regression and correlation-based network analyses. Subsequently, we analyzed the risk of disease progression associated with the identified pairs. Results: A total of 448 variants associated with CKD occurrence were identified, with significant differences in several genetic variants and metabolites observed among patients with DKD, HN, IgAN, and MN compared to healthy individuals. Among 36 SNP-metabolite pairs, those involing FOXB1 and ZFP42 were associated with DKD, whereas pairs involving MMRN1 and SYNJ2 were linked to MN. Notably, the rs1025170 variant in FOXB1 and tyrosine pair was correlated with DKD progression. Conclusion Integrating genomics and metabolomics across independent cohorts enables the discovery of cause-specific biomarkers for the occurrence and progression of CKD in the Korean population.

This case report explores the orthodontic treatment of pediatric patients with mild skeletal malocclusion using Invisalign First®. Two cases are presented: (1) a patient with upper incisor protrusion, deep bite, and skeletal Class II malocclusion; and (2) a patient with dental crowding and skeletal Class III malocclusion. Their treatment demonstrated the efficacy of Invisalign First® in achieving arch expansion, tooth alignment, space creation for erupting teeth, and skeletal malocclusion correction. The overall results were satisfactory; however, limitations in rotational and intrusive movements, as well as skeletal improvements, were observed. Careful treatment planning, including overcorrection and patient selection, is essential for achieving optimal outcomes.

This case report explores the orthodontic treatment of pediatric patients with mild skeletal malocclusion using Invisalign First®. Two cases are presented: (1) a patient with upper incisor protrusion, deep bite, and skeletal Class II malocclusion; and (2) a patient with dental crowding and skeletal Class III malocclusion. Their treatment demonstrated the efficacy of Invisalign First® in achieving arch expansion, tooth alignment, space creation for erupting teeth, and skeletal malocclusion correction. The overall results were satisfactory; however, limitations in rotational and intrusive movements, as well as skeletal improvements, were observed. Careful treatment planning, including overcorrection and patient selection, is essential for achieving optimal outcomes.

This case report explores the orthodontic treatment of pediatric patients with mild skeletal malocclusion using Invisalign First®. Two cases are presented: (1) a patient with upper incisor protrusion, deep bite, and skeletal Class II malocclusion; and (2) a patient with dental crowding and skeletal Class III malocclusion. Their treatment demonstrated the efficacy of Invisalign First® in achieving arch expansion, tooth alignment, space creation for erupting teeth, and skeletal malocclusion correction. The overall results were satisfactory; however, limitations in rotational and intrusive movements, as well as skeletal improvements, were observed. Careful treatment planning, including overcorrection and patient selection, is essential for achieving optimal outcomes.

OBJECTIVES: In September 2023, an outbreak of food-borne disease occurred among students on a training ship docked in Busan. This was an epidemiological investigation with the aim of improving infection prevention activities and group meal service practices on board ships. METHODS: In this study, a case was defined as an individual who experienced diarrhea more than twice a day during their training period aboard the training ship. A total of 171 exposed individuals including 6 food handlers was well-defined; therefore, a retrospective cohort study was conducted. We administered a questionnaire and conducted laboratory tests including 38 rectal swab samples. Relative risk (95% confidence interval) for each food item was calculated. RESULTS: Of the 165 students and school staff members, 41 met the case definition, resulting in an attack rate of 24.8%; all cases were students. The shape of the epidemic curve was unimodal, with the peak from 00:00 to 06:00 on September 7, 2023. Clostridium perfringens was detected in 9 cases, and no other pathogens were found. Significant relative risk was shown in 11 different food items. CONCLUSIONS C. perfringens was the causative pathogen of this outbreak on the training ship. Due to the lack of preserved food samples, the exact source of infection could not be confirmed. Ships are not classified as collective dining facilities, leaving them in a management blind spot. Therefore, specialized guidelines, voluntary inspections by the operating entities, and continuous education for managers and staff are necessary.

This study aimed to evaluate various factors related to cooperation levels in pediatric dentistry and determine their correlation with children’s cooperation during dental treatments. This study included one hundred children and their guardians who visited the dental hospital at the Chonnam National University. Children and their guardians completed surveys regarding dental fear, dental caries experience, dental treatment experience, temperament, and guardians’ dental anxiety, as well as the background characteristics of the children. Based on these data, factors associated with children’s cooperation during dental treatment were investigated. Dental fear, caries experience during the primary and mixed dentition stages, and temperament traits such as shyness and negative emotionality significantly impacted children’s cooperation during dental visits, with higher levels of these factors corresponding to lower cooperation. The extent of dental experience also modestly influenced children’ s cooperation, with higher levels of cooperation observed in children with greater dental experience. Additionally, children’s dental fear was strongly correlated with guardians’ dental anxiety, increasing as guardians’ anxiety levels increased. Twelve-year-old children exhibited significantly lower levels of dental fear compared to other age groups, and regardless of cooperation levels, injections (shots) were identified as the primary factor inducing dental fear among the children. To improve children’ s cooperation in pediatric dentistry, strategies should focus on alleviating their fears and adopting an individualized approach that consider their oral health status and temperamental traits.

This study analyzed parents’ perceptions of pediatric dentistry and pediatric dental specialists, identified factors influencing their choice of dental practice for children, and compared perceptions between those with and without pediatric dentistry experience. A nationwide online survey (February 15 - 19, 2024) was conducted among 500 parents of children aged 15 years or younger: 170 from Seoul/Gyeonggi/ Incheon, 100 each from Chungcheong, Gyeongsang, Jeolla, and 30 from Gangwon. Data covered demographics, factors influencing dentist selection for children, awareness of pediatric dentists, and insights on whether parents had visited a pediatric dentist. 75.6% had visited a pediatric dental clinic, and 49.6% recognized pediatric dental specialists. Among visitors, 59.5% were aware of pediatric dental specialists, compared to 18.9% of non-visitors. Furthermore, 90.7% of parents aware of pediatric dental specialists had visited a clinic, versus 60.7% of those unaware. The highest visit rates were among parents with three children, especially aged 7 - 9. Awareness of pediatric dental specialists was highest among parents in their 20s, living in Gangwon, Seoul, Gyeonggi, and Incheon regions, with professional occupations and household monthly incomes of 7.5 - 8.5 million won. Parents with experience visiting pediatric dental clinics prioritized dentists’ expertise; those without experience prioritized short waiting times. Prior experience with pediatric dental clinics significantly increased the intention to revisit and reduced hesitation. Improving parents’ perceptions of pediatric dentists enhances decision-making and accessibility for children’s specialized dental care. Professional associations must raise awareness of pediatric dentistry. Pediatric dentists should prioritize expertise and advance their specializations in pediatric orthodontics.

Patients with pediatric cancer often undergo multiple therapies, such as chemotherapy, radiation therapy, and stem cell transplantation. These treatments, while essential, can result in dental developmental issues, including hypodontia, microdontia, short roots, and delayed dental development. This report presents two cases of pediatric patients diagnosed with neuroblastoma who exhibited severe tooth mobility due to short roots as a complication of cancer treatment. Moreover, we investigated the conservative management of the patients’ conditions using resin wire splints and orthodontic miniscrews for skeletal anchorage along with long-term follow-ups to evaluate their prognosis.

This study aimed to analyze the prevalence and severity of infraoccluded primary molars (IPM) and their correlation with the agenesis of permanent successors (APS). A total of 4,011 panoramic radiographs from children aged 4 to 11 years who had all 8 primary molars were examined. The prevalence of APS was analyzed based on the severity and tooth type of IPM. The prevalence of IPM was 13.0%, and there was no difference between genders. The majority of the children had two IPMs each. In all tooth types, mild infraocclusion was the most prevalent, whereas severe infraocclusion was the least frequent. Among the types of primary molars, the lower primary first molar (62.3%) was the most affected, followed by the lower primary second molar (27.7%), the upper primary second molar (5.8%), and the upper primary first molar (4.2%). Infraocclusion was 11.2 times more prevalent in the mandible than in the maxilla, with no significant difference between the left and right sides. The correlation between IPM and APS was also investigated. Among the subjects, 177 had one or more agenesis of premolars, of whom 54 (30.5%) had IPM. Additionally, among the 521 individuals with IPM, 54 individuals exhibited APS (10.4%). This study identified a noteworthy prevalence of infraocclusion, with notable variations among molar types. The LPFM was particularly affected. The majority of cases were classified as mild in severity. Furthermore, a compelling association between IPM and APS was established. Understanding this connection may enhance treatment strategies for infraoccluded teeth and tooth agenesis.

This report aims to describe a case of tumor-like lymphoplasmacytic conjunctivitis in a 7-year-old spayed-female Pomeranian. On complete ophthalmic examination, a mass with papillary projections was noted on the bulbar surface of the right third eyelid. Debulking of the mass was performed while preserving as much of the third eyelid as possible. On the histopathological examination, the mass was diagnosed as lymphoplasmacytic conjunctivitis with mild epithelial hyperplasia. Although a slight regrowth of the mass was noted 3 weeks after surgery, intralesional injection of triamcinolone acetonide led to its disappearance.There was no further recurrence after 5 months.