We aimed to develop evidence-based recommendations for treating axial spondylarthritis (axSpA) in Korea. The development committee was constructed, key clinical questions were determined, and the evidence was searched through online databases including MEDLINE, Embase, Cochrane, KoreaMed, and KMbase. Systematic literature reviews were conducted, quality of evidence was determined, and draft recommendations were formulated according to the Grading of Recommendations Assessment, Development, and Evaluations methodology. Recommendations that reached 80% consensus among a voting panel were finalized. Three principles and 21 recommendations were determined. Recommendations 1 and 2 pertain to treatment strategies, regular disease status assessment, and rheumatologist-steered multidisciplinary management. Recommendations 3 and 4 strongly recommend patient education, exercise, and smoking cessation. Recommendations 5~12 address pharmacological treatment of active disease using nonsteroidal anti-inflammatory drugs, glucocorticoids, sulfasalazine, biologics, and Janus kinase inhibitors.Recommendations 13~16 address treatment in stable disease. We suggest against spa and acupuncture as therapies (Recommendation 17). Recommendations 18 and 19 pertain to total hip arthroplasty and spinal surgery. Monitoring of comorbidities and drug toxicities are recommended (Recommendations 20 and 21). Recommendations for axSpA treatment in a Korean context were developed based on comprehensive clinical questions and evidence. These are intended to guide best practice in the treatment of axSpA.

We aimed to develop evidence-based recommendations for treating axial spondylarthritis (axSpA) in Korea. The development committee was constructed, key clinical questions were determined, and the evidence was searched through online databases including MEDLINE, Embase, Cochrane, KoreaMed, and Kmbase. Systematic literature reviews were conducted, quality of evidence was determined, and draft recommendations were formulated according to the Grading of Recommendations Assessment, Development, and Evaluations methodology. Recommendations that reached 80% consensus among a voting panel were finalized. Three principles and 21 recommendations were determined. Recommendations 1 and 2 pertain to treatment strategies, regular disease status assessment, and rheumatologist-steered multidisciplinary management. Recommendations 3 and 4 strongly recommend patient education, exercise, and smoking cessation. Recommendations 5–12 address pharmacological treatment of active disease using nonsteroidal anti-inflammatory drugs, glucocorticoids, sulfasalazine, biologics, and Janus kinase inhibitors. Recommendations 13–16 address treatment in stable disease. We suggest against spa and acupuncture as therapies (Recommendation 17). Recommendations 18 and 19 pertain to total hip arthroplasty and spinal surgery. Monitoring of comorbidities and drug toxicities are recommended (Recommendations 20 and 21). Recommendations for axSpA treatment in a Korean context were developed based on comprehensive clinical questions and evidence. These are intended to guide best practice in the treatment of axSpA.

Purpose: This study aimed to assess the association between physical activity and pregnancy in 6 months among infertile women who underwent in vitro fertilization (IVF). Methods: The participants included in this study were infertile women who underwent IVF at Cha Fertility Center in Seoul Station from October 2019 to February 2020. Of 132 women who agreed to participate in the study, one was eliminated for omitting the exercise questionnaire. A survey assessing the level of physical activity of infertile women was conducted using the Korean version of the International Physical Activity Questionnaires. We calculated metabolic equivalent task-minutes (MET-min) scores and obtained their IVF results after 6 months of the survey. Participants with less than 3,000 MET-min were classified into the minimally active group, and those with ≥3,000 MET-min were classified as the healthenhancing group. The 2 groups were compared based on age, anti-Müllerian hormone levels, body mass index, infertility duration, nulliparity, harmful alcohol drinking, history of smoking, obesity, male factors, and pregnancy rates. Adjusted relative risk for pregnancy was calculated using log-binomial regression analysis. Results: There was no significant difference in basal characteristics between the less active and health-enhancing groups. When controlling for all covariates, the relative risk for pregnancy was close to null with health-enhancing activity. The adjusted pregnancy rate decreased with increasing MET-min in the generalized additive model. Conclusion We observed no positive association between physical activity and pregnancy rate among interfile women undergoing IVF. To confirm our findings, subsequent interventional studies would be needed.

Purpose: This study aimed to assess the association between physical activity and pregnancy in 6 months among infertile women who underwent in vitro fertilization (IVF). Methods: The participants included in this study were infertile women who underwent IVF at Cha Fertility Center in Seoul Station from October 2019 to February 2020. Of 132 women who agreed to participate in the study, one was eliminated for omitting the exercise questionnaire. A survey assessing the level of physical activity of infertile women was conducted using the Korean version of the International Physical Activity Questionnaires. We calculated metabolic equivalent task-minutes (MET-min) scores and obtained their IVF results after 6 months of the survey. Participants with less than 3,000 MET-min were classified into the minimally active group, and those with ≥3,000 MET-min were classified as the healthenhancing group. The 2 groups were compared based on age, anti-Müllerian hormone levels, body mass index, infertility duration, nulliparity, harmful alcohol drinking, history of smoking, obesity, male factors, and pregnancy rates. Adjusted relative risk for pregnancy was calculated using log-binomial regression analysis. Results: There was no significant difference in basal characteristics between the less active and health-enhancing groups. When controlling for all covariates, the relative risk for pregnancy was close to null with health-enhancing activity. The adjusted pregnancy rate decreased with increasing MET-min in the generalized additive model. Conclusion We observed no positive association between physical activity and pregnancy rate among interfile women undergoing IVF. To confirm our findings, subsequent interventional studies would be needed.

The aims of this study were to determine the short-term effectiveness of an internet-based lifestyle modification (LSM) program in preventing the onset of type 2 diabetes mellitus (T2DM) in prediabetes patients in community settings. A total of 415 subjects who were diagnosed with prediabetes were randomly assigned to the LSM and standard management (SM) groups. After the 6-month intervention, the LSM group had a statistically significant reduction in body weight, body mass index compared to the SM group participants. In the LSM group, blood glucose levels were significantly decreased after intervention and the clinical improvement effect was evident in the group that achieved the target weight loss of 5% or more of the initial weight for 6 months. Internet-based 6-month-intensive LSM programs conducted by public health center personnel are an effective way to provide lifestyle intervention programs and encourage maintenance of healthy behaviors in subjects with a high risk of T2DM in community settings.

This study was to find out whether the rendering screen difference affect to measuring distance in a CAD program according to three types of CAD programs. Materials and methods: The model presented in ISO 12836 for dental scanner evaluation was reduced by 70%. This model was repeatedly scanned 15times using Trios II (3Shape, Denmark). Using the output STL file, 3Shape CAD, inLab 15, and ExoCAD programs were used to measure the horizontal distance (H) and vertical distance (V) between adjacent point angle, and for each experiment, three groups were set according to the CAD program type. Statistical analysis was performed using One-way ANOVA test and post hoc was performed using Dunnett T3 test. Results: In the horizontal and vertical distance measurement, there was no difference in the average of the measured values between the three groups according to the CAD program (P>.05). Conclusion: There were no effect of the difference in the rendering screen in the horizontal and vertical linear distance measurements of the inlay model on the dental CAD program.