Objective:To conduct a cost-utility analysis of Tuberculosis Preventive Treatment(TPT)strategies for Latent Tuberculosis Infection(LTBI)individuals,providing a scientific basis for the implementation of TPT strategies and fund allocation.Methods:Based on a simulated population of 100 000 LTBI individuals,a decision tree-Markov Model was constructed to compare the cost-utility of six TPT strategies over 20 years.Results:Compared with no treatment,3HP-SAT,3HP-DOT,3HR-SAT,3HR-DOT and Vaccae could prevent 91.08％,94.15％,83.49％,87.18％and 53.13％of ATB cases,respectively,and avoid 3.55％,3.70％,3.30％,3.43％,and 2.06％of LTBI individuals from dying of ATB.Except for Vaccae,other schemes could reduce costs and improve QALYs,being absolutely dominant strategies,while Vaccae was a relatively dominant strategy.3HP under DOT was more cost-utility than that under SAT.Sensitivity analysis showed that the utility value of curing ATB was the only parameter affecting the ICUR result,and the model result was stable and reliable.When the WTP threshold was greater than 41 608.54 yuan/QALY,3HP-DOT was better than 3HP-SAT;otherwise,3HP-SAT was the optimal strategy.Conclusion:TPT for LTBI individuals has high cost-utility value.Clarifying the advantages of short-course therapy helps promote the implementation of TPT strategies and contributes to achieving the goal of"ending tuberculosis".

Objective:To conduct a cost-utility analysis of Tuberculosis Preventive Treatment(TPT)strategies for Latent Tuberculosis Infection(LTBI)individuals,providing a scientific basis for the implementation of TPT strategies and fund allocation.Methods:Based on a simulated population of 100 000 LTBI individuals,a decision tree-Markov Model was constructed to compare the cost-utility of six TPT strategies over 20 years.Results:Compared with no treatment,3HP-SAT,3HP-DOT,3HR-SAT,3HR-DOT and Vaccae could prevent 91.08％,94.15％,83.49％,87.18％and 53.13％of ATB cases,respectively,and avoid 3.55％,3.70％,3.30％,3.43％,and 2.06％of LTBI individuals from dying of ATB.Except for Vaccae,other schemes could reduce costs and improve QALYs,being absolutely dominant strategies,while Vaccae was a relatively dominant strategy.3HP under DOT was more cost-utility than that under SAT.Sensitivity analysis showed that the utility value of curing ATB was the only parameter affecting the ICUR result,and the model result was stable and reliable.When the WTP threshold was greater than 41 608.54 yuan/QALY,3HP-DOT was better than 3HP-SAT;otherwise,3HP-SAT was the optimal strategy.Conclusion:TPT for LTBI individuals has high cost-utility value.Clarifying the advantages of short-course therapy helps promote the implementation of TPT strategies and contributes to achieving the goal of"ending tuberculosis".

The study used the Delphi method to conduct two rounds of expert consultations involving 23 experts nationwide, aiming to establish the comprehensive index system for field epidemiological investigations of viral respiratory infectious diseases and determine the weights assigned to each index through the hierarchical analysis. Both rounds of consultation witnessed a 100% participation rate among all experts, with a coefficient of authority (Cr) reaching 0.89. The Kendall′s W coefficients for assessing the importance and feasibility in both rounds were 0.108, 0.234, 0.439 and 0.427, respectively. Finally, an index system consisting of seven first-level indicators, 18 second-level indicators, and 36 third-level indicators was constructed for the technical guidelines governing field epidemiological investigations into viral respiratory infectious diseases, and the weight of each indicator was established. The index system constructed in this study has a high degree of scientificity, reliability and operability, but it still needs to be further adjusted and improved in combination with the epidemiological characteristics of viral respiratory infectious diseases.

The study used the Delphi method to conduct two rounds of expert consultations involving 23 experts nationwide, aiming to establish the comprehensive index system for field epidemiological investigations of viral respiratory infectious diseases and determine the weights assigned to each index through the hierarchical analysis. Both rounds of consultation witnessed a 100% participation rate among all experts, with a coefficient of authority (Cr) reaching 0.89. The Kendall′s W coefficients for assessing the importance and feasibility in both rounds were 0.108, 0.234, 0.439 and 0.427, respectively. Finally, an index system consisting of seven first-level indicators, 18 second-level indicators, and 36 third-level indicators was constructed for the technical guidelines governing field epidemiological investigations into viral respiratory infectious diseases, and the weight of each indicator was established. The index system constructed in this study has a high degree of scientificity, reliability and operability, but it still needs to be further adjusted and improved in combination with the epidemiological characteristics of viral respiratory infectious diseases.