1.Translational Research in Lymphedema:From Animal Models to the Establishment of Pharmacotherapy
Masaki SANO ; Satoshi HIRAKAWA ; Yurina YOKOYAMA ; Ayumi SHIMODA ; Noriko OGURA ; Shunji TAKASHIMA ; Tetsuyuki NAGAFUSA ; Yusuke OTA ; Shota KAKINUMA ; Katsuya YAMAUCHI ; Hiroya TAKEUCHI ; Masahiro NAKAGAWA
The Japanese Journal of Rehabilitation Medicine 2025;62(9):921-927
2.Outcome of intradiscal condoliase injection therapy for patients with recurrent lumbar disc herniation
Noritaka SUZUKI ; Yawara EGUCHI ; Takashi HIRAI ; Takuya TAKAHASHI ; Yohei TAKAHASHI ; Kota WATANABE ; Tomohiro BANNO ; Kyohei SAKAKI ; Satoshi MAKI ; Yuuichi TAKANO ; Yuki TANIGUCHI ; Yasuchika AOKI ; Takamitsu KONISHI ; Yutaka HIRAIZUMI ; Masatsune YAMAGATA ; Akihiro HIRAKAWA ; Seiji OHTORI
Asian Spine Journal 2024;18(4):550-559
Methods:
The study participants were 249 patients who underwent intradiscal condoliase injection for LDH at nine participating institutions, including 241 patients with initial LDH (group C) and eight with recurrent LDH (group R). Patient characteristics including age, sex, body mass index, disease duration, intervertebral LDH level, smoking history, and diabetes history were evaluated. Low back pain/leg pain Numerical Rating Scale (NRS) scores and the Oswestry Disability Index (ODI) were used to evaluate clinical symptoms before treatment and at 6 months and 1 year after treatment.
Results:
Low back pain NRS scores (before treatment and at 6 months and 1 year after treatment, respectively) in group C (4.9 → 2.6 → 1.8) showed significant improvement until 1 year after treatment. Although a tendency for improvement was observed in group R (3.5 → 2.8 → 2.2), no significant difference was noted. Groups C (6.6 → 2.4 → 1.4) and R (7.0 → 3.1 → 3.2) showed significant improvement in the leg pain NRS scores after treatment. Group C (41.4 → 19.5 → 13.7) demonstrated significant improvement in the ODI up to 1 year after treatment; however, no significant difference was found in group R (35.7 → 31.7 → 26.4).
Conclusions
Although intradiscal condoliase injection is less effective for LDH recurrence than for initial cases, it is useful for improving leg pain and can be considered a minimally invasive and safe treatment method.
3.Relationships between throwing injuries and functional movement screen in junior high school baseball players
Tomoya Uchida ; Shintaro Matsumoto ; Minoru Komatsu ; Yuki Noda ; Miya Ishida ; Michiru Tsukuda ; Ryota Nakayama ; Yuta Takeda ; Rieko Hirakawa ; Kohei Muto ; Satoshi Okubo ; Hiroyuki Furukawa ; Kenji Fujita
Japanese Journal of Physical Fitness and Sports Medicine 2016;65(2):237-242
Recently, the problem of the high incidence of throwing injuries in young people has been gaining attention. Identifying high-risk players before the onset of the throwing injury is important for prevention. One of the most widely used screening tests for sports-related injuries is the Functional Movement Screen (FMS), which assesses the quality of movement; however, its correlation with throwing injuries has not been established. The purpose of this study was to investigate the correlation between the FMS score and throwing injuries. The FMS was used during the medical check for two hundred and thirty junior high school baseball players. We allotted those who had experienced throwing injuries multiple times to the injury group and those who had never experienced throwing injury to the control group. We then calculated the FMS cutoff value using the receiver operating characteristic curve. In addition, we investigated differences in the incidence of throwing injury between above and below the cutoff value using chi-square test. The FMS cutoff score was 17. Players who scored ≤17 had a significantly higher incidence of throwing injuries than those who scored ≥18. Conclusion: We believe that FMS score is correlated to throwing injuries. In addition, the results suggest that throwing injuries might be prevented in junior high school baseball players who scored ≤17 on the FMS if they undergo training in the correct movement patterns.
4.Relations between daily energy expenditure and body fatness, physical fitness in primary school children using doubly labeled water method and accelerometer
Satoshi Nakae ; Yosuke Yamada ; Misaka Kimura ; Kazuhiro Suzuki ; Haruo Ozawa ; Kazufumi Hirakawa ; Kojiro Ishii
Japanese Journal of Physical Fitness and Sports Medicine 2013;62(5):353-360
The relationships between physical activity and childhood body size, low physical fitness epidemic are still unclear. The purpose of this study was to examine the relationship between energy expenditure estimated by doubly labeled water (DLW) method and body fatness, physical fitness in children, and the relationship between physical activity levels and percent time spent in activities. 30 healthy Japanese children (20 boys and 10 girls) participated in this study. The total energy expenditure (TEE) and % body fat were measured by the DLW method over a 6-day period. The physical activity-related energy expenditure (PAEE) was calculated as (TEE × 0.90) – basal metabolic rate (BMR). The physical activity level (PAL) was also calculated as TEE/BMR. The physical fitness tests (8 items) were applied to evaluate fitness, and scores of each test were calculated as overall physical fitness score. The TEE was 2009.8 ± 272.6 kcal/day, the PAEE was 558.4 ± 206.1 kcal/day and the PAL was 1.61 ± 0.18. TEE per weight and PAEE per weight (PAEE/wt) was significantly negatively correlated with % body fat (r = - 0.626; r = - 0.400, respectively). These results suggest that increasing energy expenditure is important for achieving adequate body size. The PAEE/wt was most strongly correlated with physical fitness score (r = 0.680). The PAL was associated with percent time spent of inactivity ( r = -0.506), light-moderate activity ( r = 0.450) and vigorous activity ( r = 0.545). It was suggested that physically active lifestyle would be necessary for childhood health.
5.Relationships between duration of various physical activities and physical activity level in children
Yoshitake Oshima ; Satoshi Nakae ; Yosuke Yamada ; Misaka Kimura ; Haruo Ozawa ; Kazuhiro Suzuki ; Kazuhumi Hirakawa ; Kojiro Ishii
Japanese Journal of Physical Fitness and Sports Medicine 2013;62(5):391-397
The purpose of this study was to examine the relationships between patterns of daily physical activities measured by accelerometer and physical activity level (PAL) in children. Firstly, activity intensities during incremental exercise were measured using a tri-axial accelerometer (HJA-350IT) in twenty one children aged 10.6 ± 0.9 years. As a result of receiver-operating characteristic curve analysis, the cut-off value for discrimination between walking and running activity was set at 7.2 METs of HJA-350IT. Secondly, total energy expenditure (TEE) in daily life was measured by doubly labeled water method, and durations of lifestyle, walking, and running activities were measured by the accelerometer in 6th grade elementary school children (11 boys and 10 girls). TEE and physical activity level (PAL) were 2,021 ± 343 kcal/day and 1.56 ± 0.17, respectively. The average durations of lifestyle, walking and running activities were 188 ± 30 min/day (50.6 ± 6.0 %), 171±28 min/day (45.9 ± 5.0 %) and 13.3 ± 7.6 min/day (3.5 ± 1.8 %), respectively. The proportion of the duration of running activity was positively correlated with PAL (r = 0.615, p < 0.01), and the proportion of the duration of lifestyle activity was negatively correlated with PAL (r = -0.439, p < 0.05). There was no relationship between the proportion of the duration of walking activity and PAL (r = 0.300, n.s.). These results suggest that running activity is important to increase PAL more than ever in primary school children.


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