Backround Peutz–Jeghers (PJ) syndrome is a rare autosomal dominant disorder characterized by a mucocutaneous pigmentationon on oral mucosa and multiple hamartomatous polyps located in the digestive tract except esophagus. PJ syndrome can be diagnosed in early childhood by a characteristic pigmentation and family history of polyposis. However, it is often diagnosed first as a polyp in the small intestine that causes obstruction and intussusception and is often treated with a bowel resection. If diagnosed in young childhood, an effective non-invasive method is to resect the polyps by tying off the blood supply to the polyps, that is the method named ischemic polypectomy, before they grow to the point of obstruction using a endoscopy. PJ syndrome is rare in Mongolia, but in severe cases, small intestine polyps are treated only surgically. Double-balloon-endoscopy (DBE) has been performed at the Mongolian- Japanese Hospital since 2023, making it possible to diagnose and treat the syndrome endoscopically. Our patient, a 15-year-old boy, had a mucocutaneous pigmentation that had been previously undiagnosed and was first diagnosed with intussusception at the age of 13. He had undergone 4 endoscopic procedures for upper and lower gastrointestinal polyps at the National Center for Maternal and Child Health successfully. In our hospital, we found endoscopically multiple hamartomatous polyps of various sizes between 1-3 cm, and a 3 mm diameter tumor that filled 3/4 of the intestinal lumen was treated by ischemic polypectomy. After the procedure, there were no early or late complications related to the procedure. The child's condition improved, the main complaints subsided, and he continues his daily life normally. However, follow-up DBE is required.

Introduction: Factors such as social and economic conditions, technological development, modern urbanization, lifestyle, physical activity, nutrition, and air pollution affect physical growth and development. Aim: To study the physical development of Mongolian children. Objectives: 1. To measure the physical indices (weight, height) of children aged 6-17 years old with some influencing factors. Material and method: Using a random sampling method, children's body height and weight were examined at a particular point in time using widely accepted methods. Statistical analysis was performed using the "SPSS ver.25" program. Result: The growth of children's height and weight is progressing according to general patterns of age and gender. Girls grow rapidly between the ages of 10-13 and stabilize after wards, while boys a sharp growth spurt between the ages of 13-17, with the average height of 17-year-old boys being 171.44 cm and 160.25 cm for girls, which is slightly higher than previous studies (Otgon G, 2006, Munkhzaya M, 2020). The trend of weight growth is more prominent in boys. However, compared to international standards (Russia, WHO, CDC), our children's height and weight are lower. The statistics show that parental education, income, exercise, and living environment positively influence growth and development, whereas excessive television watching and air pollution negatively affect it (p< 0.05). Conclusion 1. Children's growth is normal, but observed increase of the body weight of boys. Having healthy and well educated parents, as well as engaging in physical activity positively influences children's height. A lack of physical activity negatively affects height and increases weight. Mongolian children are shorter and lighter compared to foreign children (from Russia and America - CDC).

Background: Serum natriuretic peptide (NT-proBNP) is a critical biomarker for diagnosing left ventricular dysfunction. Heart failure is the leading cause of mortality in chronic kidney disease (CKD), emphasizing the need for its early detection and prognosis. Objective: This study aimed to determine the serum NT-proBNP levels in participants with CKD and establish a cut-off value for predicting heart failure. Methods: A descriptive cross-sectional study was conducted from April 1 to July 1,2024. This study received approval from the Ethics Committee of the Institute of Medical Sciences (Approval No.24/01). A total of 117 CKD patients hospitalized in the Nephrology and Endocrinology Department of the third state hospital were enrolled based on predefined inclusion and exclusion criteria. Data were collected using questionnaires, laboratory and heart ultrasound test results. Serum NT-proBNP levels were measured using a rapid immunofluorescence quantitative analyzer. Data were analyzed with SPSS 26.0. Results: The mean age of the 117 participants was 57.9 ± 14.7 years, with 51.3% being male. The mean serum NT-proBNP level was 7686 ± 12149 pg/mL. Statistically significant differences were observed in serum creatinine, sodium, calcium, CKD stage, and arterial hypertension between genders (p<0.05). NT-proBNP levels in hemodialysis patients differed significantly between heart failure and non-heart failure groups (p<0.05). Significant differences were also found in hemoglobin, serum albumin, NT-proBNP levels, and CKD stages (p<0.05). NT-proBNP correlated significantly with risk factors such as hemodialysis, diabetes, and decreased systolic blood pressure (p<0.0001). A weak inverse relationship was noted between systolic blood pressure and NT-proBNP (R² = 0.16). The NT-proBNP cut-off value for predicting heart failure was 3027 pg/mL, with an AUC of 61.7% (sensitivity: 74.5%, specificity: 55%). Conclusion Serum NT-proBNP levels are elevated in CKD patients regardless of heart failure. The established cut-off value for NT-proBNP in CKD patients to detect heart failure was 3027 pg/mL, with moderate diagnostic utility (AUC = 61.7%).

BACKGROUND: According to the United Nations, drug reports 2016, 250 million people aged 15 to 64 an estimated 29 million of them have used drugs and narcotics. The United nations states that the drug and narcotic manufacturing have increased by three times in east 15 years. Mongolia is located between Russia and China that are the most drug used countries in the world and it can increase the risk of drug usage in Mongolia. OBJECTIVE: Study to knowledge and attitude about drugs and narcotics among the high school, college and universities students in Ulaanbaatar. METHODS: The research was conducted among the school, college and universities students and the analytic research method was used in our research. 176 middle and high school students, 215 university students and 70 college students from morning classes were participated in the survey. The survey research was used method of collecting information and materials about the drug usage and narcotics. SPSS 17 was used for statistical analysis. RESULTS: The highest point was 16 (n=1) and lowest point was 0 (n=16) and the knowledge of drugs among the students was 8.14. Results releated that 7.8% (n=36) of students have enough information about the drugs and narcotics, 62.9% (n=261) of students did not have enough information and 29.3% (n=135) of them have informed moderately. CONCLUSIONS: Exploring the knowledge about drugs and narcotics among the students, 7.8% of them have enough information, 62.9% of them did not have enough information and 29.3% of them have informed moderately

Introduction: In recent years, there is no scientific epidemiological data about prevalence and risk factors of bronchial asthma among population in Mongolia. Goal: The aim of this study was to define some risk factors of bronchial asthma among urban adults. Materials and Methods: 1201 adults were randomly chosen aged over 20 years who lives in different districts of Ulaanbaatar city. The participants were interviewed using a modified questionnaire of “Global Initiative for Asthma” - GINA. Besides demographic data, information on smoking habits and atopic symptoms was collected. Univariate and multivariate logistic regression modeling was performed to calculate odds ratio of various potential risk factors. The lung function of subjects was checked using a spirometry Easyone, calculating the indexes Forced expiratory volume 1sec (FEV1), forced vital capacity (FVC), FEV1/FVC ratio. Results: Of the respondents, 606 were males (50.5%) and 595 were females (49.5%). Asthma was more frequent in female than in male. The prevalence of wheezing and physician-diagnosed asthma was higher in overweight and obese than in normal weight. The BMI was higher in group with wheezing than in group without wheezing (p<0.01). 54% of subjects with bronchial asthma were smokers. The mean value for FEV1 was 2.86±0.85 L and FVC was 3.60±0.94 L in overall and the lung function was lower in smokers than in non-smokers with bronchial asthma. 28.4% of subjects with allergic rhinitis has current asthma, while 11.6% of subjects without allergic rhinitis has asthma (p<0.01). Conclusion: Female sex, advancing age, history of allergic rhinitis, tobacco smoking and body mass index were associated with significantly higher odds of having asthma.

Introduction: According to World Health Organization, air pollution is a major environmental risk to health and is estimated to cause approximately 1.6 million premature deaths worldwide per year. The air pollution of Ulaanbaatar city is rising year after year.Goal: The aim of this study was to define the lung function of adults in Ulaanbaatar.Materials and Methods: 1196 adults were randomly chosen aged over 20 years of Ulaanbaatar city. Of them 238 subjects were excluded because they had at least one of the following: a history of lung diseases including asthma, COPD, pulmonary tuberculosis, lung fibrosis; symptoms of chronic cough, wheeze, or dyspnea; history of thoracic surgery; history of major acute illness in the past 3 months; or a history of respiratory tract infection in the past 4 weeks. Besides demographic data, information on smoking habits was collected. The lung ventilation function of subjects was checked using a spirometry EasyOne, calculating the indexes Forced expiratory volume 1sec (FEV1), forced vital capacity (FVC), FEV1/FVC ratio. Lung function measurements followed a standardized protocol and fulfilled the ATS criteria.Results: Of the respondents, 486 were males (50.7%) and 472 were females (49.3%). There was a negative correlation between each lung function and age (p<0.05). The lung function was significantly lower in female than in male, for FEV1, FVC (male - FEV1 3.66±0.659 L, FVC 4.467±0.716 L, female-FEV1 2.663+0.559 L, FVC 3.237+0.586 L). In overall, FVC, FEV1 was decreased by 34.5, 37.2 percent, respectively compared with European LLN value.Conclusion: The mean value for FEV1, FVC, FEV1/FVC ratio was 3.17±0.78 L, 3.86+0.89 L and 82.02±6.75 % in overall, respectively.