Objective To investigate the correlation between the triglyceride-glucose index(TyG),atherogenic index of plasma(AIP),systemic immune-inflammation index(SII),serum creatinine(SCr)and the severity of hyperlipidemic acute pancreatitis(HLAP).Methods A total of 156 HLAP patients admitted to Huzhou First People's Hospital from January 2020 to December 2024 were enrolled as subjects.They were divided into mild group(n=89)and moderately-severe/severe group(n=67)based on disease severity.Logistic regression analysis was used to identify independent risk factors.Spearman correlation analysis was used to examine the correlation between TyG,AIP,SCr,and HLAP severity.The predictive value of TyG,AIP,and SCr for HLAP were evaluated using receiver operating characteristic(ROC)curves.Results Levels of TyG,AIP,SII,and SCr were significantly higher in moderate-severe/severe group than in mild group(P＜0.05).Logistic regression analysis revealed that TyG,AIP,and SCr were independent risk factors for moderate-severe/severe HLAP(P＜0.05),whereas SII was not an independent risk factor.The severity of HLAP was positively correlated with early admission levels of TyG,AIP,and SCr.ROC curve analysis demonstrated that TyG showed superior diagnostic value compared to SCr and AIP.The combined indicators(SCr+AIP and SCr+TyG)outperformed single indicators in predictive value,with SCr+TyG exhibiting the highest predictive efficacy.Conclusion Early TyG,AIP,and SCr levels can serve as effective indicators for predicting disease severity in HLAP patients,and combined detection improves predictive accuracy.

Objective To investigate the correlation between the triglyceride-glucose index(TyG),atherogenic index of plasma(AIP),systemic immune-inflammation index(SII),serum creatinine(SCr)and the severity of hyperlipidemic acute pancreatitis(HLAP).Methods A total of 156 HLAP patients admitted to Huzhou First People's Hospital from January 2020 to December 2024 were enrolled as subjects.They were divided into mild group(n=89)and moderately-severe/severe group(n=67)based on disease severity.Logistic regression analysis was used to identify independent risk factors.Spearman correlation analysis was used to examine the correlation between TyG,AIP,SCr,and HLAP severity.The predictive value of TyG,AIP,and SCr for HLAP were evaluated using receiver operating characteristic(ROC)curves.Results Levels of TyG,AIP,SII,and SCr were significantly higher in moderate-severe/severe group than in mild group(P＜0.05).Logistic regression analysis revealed that TyG,AIP,and SCr were independent risk factors for moderate-severe/severe HLAP(P＜0.05),whereas SII was not an independent risk factor.The severity of HLAP was positively correlated with early admission levels of TyG,AIP,and SCr.ROC curve analysis demonstrated that TyG showed superior diagnostic value compared to SCr and AIP.The combined indicators(SCr+AIP and SCr+TyG)outperformed single indicators in predictive value,with SCr+TyG exhibiting the highest predictive efficacy.Conclusion Early TyG,AIP,and SCr levels can serve as effective indicators for predicting disease severity in HLAP patients,and combined detection improves predictive accuracy.

Objective To study the protective effect of δ opioid receptor agonist DADLE(D-Ala2-D-Leu5-enkephalin)on mitochondrial respiratory function in a rat model of sepsis. Methods Sixty SD rats were randomly divided in to sham operated group (SO), septic group (SEP), and DADLE group (DADLE), each of 20 cases. Sepsis model was produced by cecal ligation and puncture (CLP). In SO group,the abdomen was opened without any other treatment. In DADLE group, DADLE (0.5 mg/mL) was administer at a dose of 5 mL/kg by intra-peritoneal injection after CLP. All rats were sacrificed 8 hours after CLP. ALT and AST in blood were determined. Mitochondrial respiratory function was evaluated by the clark oxygen eletrode. The levels of ATP, ADP, AMP were determined by high performance liquid chromatogra phy (HPLC). Results RCR and ADP/O in DADLE group were much higher than that in SEP group (P<0.05). ATP in DADLE groups were much higher than SEP group (P<0.05), while ALT and AST of DADLE group were significantly lower than SEP group (P<0.05). Conclusion DADLE can protect mitochondrial respiratory function and improve the hepatocellular energy metabolism in sepsis.