A 51-year-old male patient was admitted to People’s Hospital, Hubei University of Medicine due to multiple subcutaneous masses in the left upper limb and other body regions for over 50 years and was diagnosed as neurofibromatosis type Ⅰ (NF1) combined with a rare giant neurofibroma in the left upper limb. The patient had developed subcutaneous masses and café-au-lait spots since childhood, with the left upper limb mass rapidly enlarged to 56 cm × 38 cm over time, accompanied by hemorrhage and ulceration. Preoperative MRI revealed a soft tissue mass in the left upper limb. NF1 was diagnosed based on family history and clinical manifestations. Tumor resection was performed in stages, and the tumor tissue weighed 10.204 kg. During the operation, autologous blood reinfusion was adopted to avoid the consumption of a large amount of resources related to blood transfusion. The area around the wound was stripped to reduce the tension. The flap around the wound was sutured directly to close the wound. Neurofibroma was confirmed by postoperative pathology. The patient recovered well postoperatively, with normal blood supply to the left upper limb, survival of the skin flap, and significant functional improvement at the 2-month follow-up, leading to enhanced quality of life.

A 51-year-old male patient was admitted to People’s Hospital, Hubei University of Medicine due to multiple subcutaneous masses in the left upper limb and other body regions for over 50 years and was diagnosed as neurofibromatosis type Ⅰ (NF1) combined with a rare giant neurofibroma in the left upper limb. The patient had developed subcutaneous masses and café-au-lait spots since childhood, with the left upper limb mass rapidly enlarged to 56 cm × 38 cm over time, accompanied by hemorrhage and ulceration. Preoperative MRI revealed a soft tissue mass in the left upper limb. NF1 was diagnosed based on family history and clinical manifestations. Tumor resection was performed in stages, and the tumor tissue weighed 10.204 kg. During the operation, autologous blood reinfusion was adopted to avoid the consumption of a large amount of resources related to blood transfusion. The area around the wound was stripped to reduce the tension. The flap around the wound was sutured directly to close the wound. Neurofibroma was confirmed by postoperative pathology. The patient recovered well postoperatively, with normal blood supply to the left upper limb, survival of the skin flap, and significant functional improvement at the 2-month follow-up, leading to enhanced quality of life.