Objective To analyze the clinical characteristics of patients with Streptococcus anginosus group(SAG)infected brain abscess and provide a reference basis for the clinical diagnosis and treatment of this disease.Methods The clinical information of 59 patients with brain abscess with SAG in Guangdong Sanjiu Brain Hospital from January 2016 to October 2023 was collected for retrospective statistical analysis.Results Among the 59 patients with brain abscess,there were 52(88.14%)male and 7(11.86%)female.Among 59 cases of SAG,there were 32(54.24%)in the Str.intermedius group,21(35.59%)in the Str.constellatus group and 6(10.17%)in the Str.anginosus group.The age of Str.intermedius group was less than that of Streptococcus constellatus group(36.75±20.06 years vs 50.43±16.17 years),and the difference was statistically significant(t=2.614,P<0.05).The common clinical symptom was headache,while the probability of fever was greater in the Str.intermedius group compared to the Str.constellatus group(t=4.174,P<0.05).Abscesses were commonly solitary and were located in the parietal and frontal lobes of the brain.Patients with Str.constellatus had a greater probability of developing mixed infections compared to patiens with Str.intermedius(57.14%vs 9.38%)with significant differences(t=14.257,P<0.05).Glycopeptide(vancomycin)plus carbapenem(meropenem)combination regimen was the most commonly used in both empiric and targeted dosing were 64.41%and 52.54%,respectively.No strains resistant to common antibiotics were identified.Conclusion The SAG causing brain abscesses are mainly Str.intermedius and Str.constellatus,and the age,symptoms and infection patterns of patients with brain abscesses caused by the two bacteria were different.SAG did not appear to be drug-resistant in the clinic,and the clinic could reasonably evaluate and adjust the anti-infection regimen based on the drug sensitivity results.

Objective To analyze the clinical characteristics of patients with Streptococcus anginosus group(SAG)infected brain abscess and provide a reference basis for the clinical diagnosis and treatment of this disease.Methods The clinical information of 59 patients with brain abscess with SAG in Guangdong Sanjiu Brain Hospital from January 2016 to October 2023 was collected for retrospective statistical analysis.Results Among the 59 patients with brain abscess,there were 52(88.14%)male and 7(11.86%)female.Among 59 cases of SAG,there were 32(54.24%)in the Str.intermedius group,21(35.59%)in the Str.constellatus group and 6(10.17%)in the Str.anginosus group.The age of Str.intermedius group was less than that of Streptococcus constellatus group(36.75±20.06 years vs 50.43±16.17 years),and the difference was statistically significant(t=2.614,P<0.05).The common clinical symptom was headache,while the probability of fever was greater in the Str.intermedius group compared to the Str.constellatus group(t=4.174,P<0.05).Abscesses were commonly solitary and were located in the parietal and frontal lobes of the brain.Patients with Str.constellatus had a greater probability of developing mixed infections compared to patiens with Str.intermedius(57.14%vs 9.38%)with significant differences(t=14.257,P<0.05).Glycopeptide(vancomycin)plus carbapenem(meropenem)combination regimen was the most commonly used in both empiric and targeted dosing were 64.41%and 52.54%,respectively.No strains resistant to common antibiotics were identified.Conclusion The SAG causing brain abscesses are mainly Str.intermedius and Str.constellatus,and the age,symptoms and infection patterns of patients with brain abscesses caused by the two bacteria were different.SAG did not appear to be drug-resistant in the clinic,and the clinic could reasonably evaluate and adjust the anti-infection regimen based on the drug sensitivity results.

Objective To determine the concentration of hepatocyte growth factor (HGF) in vitreous of diabetic retinopathy (DR) and investigate the result and influence of HGF in neovascularization in proliferative diabetic retinopathy (PDR). Methods The high sensitive sandwich enzyme linked immunosorbent assay (ELISA) was used to measure the level of HGF in vitreous of normal group for 10 eyes, simple DR group for 7 eyes, PDR without iridal neovascularization group for 24 eyes, PDR with neovascularization of iris group in 9 eyes, other retinopathy group associated with neovascularization for 8 eyes. Results The mean value of HGF level in vitreous of the former groups was: (3.3 ?1.9) ?g/L in normal group; (4.8?2.5) ?g/L in simple DR group; (13.0 ?5.2) ?g/L in PDR without iridal neovascularization group; (18.6?7.2) ?g/L in PDR with neovascularization of iris group; (12.1?8.9) ?g/L in other retinopathy associated with neovascularization group. Stastistics showed that HGF level in PDR group and other retinal diseases associated with neovascularization were significantly higher than that in normal group ( P