Objective To investigate the MRI regression pattern and its relationship with prognosis in triple-negative breast cancer after neoadjuvant chemotherapy.Methods A total of 121 patients with triple-negative breast cancer were prospectively selected.All patients were given neoadjuvant chemotherapy and radical mastectomy.MRI was performed before and after neoadjuvant chemotherapy to observe their MRI regression pattern.Patients were followed up for 3 years to record their prognosis.The factors affecting prognosis of patients with triple-negative breast cancer after neoadjuvant chemotherapy were analyzed,and the MRI regression pattern and its relationship with prognosis were analyzed.Results MRI regression pattern after neoadjuvant chemotherapy was centripetal regression in 68 patients and non-centripetal regression in 53 patients(20 patients with fragmented regression and 33 patients with mixed regression).The MRI centripetal regression rate of triple-negative breast cancer patients with medium-high differentiation,stage Ⅱ,no lymph node metastasis and pathological complete response(pCR)was higher than that of patients with low differentiation,stage Ⅲ,with lymph node metastasis and no pCR,respectively(P＜0.05).Cox regression analysis showed that tumor stage,differentiation degree,pCR,MRI regression pattern were the factors affecting prognosis of triple-negative breast cancer patients after neoadjuvant chemotherapy(P＜0.05).Receiver operating characteristic(ROC)curve analysis results showed that the sensitivity of MRI regression pattern in predicting prognosis after neoadjuvant chemotherapy for triple-negative breast cancer patients was 84.62％,the specificity was 88.75％,and the area under the curve(AUC)was 0.870[95％confidence interval(CI)0.800-0.940].The disease-free survival curve of patients with MRI centripetal regression was better than that of patients with MRI non-centripetal regression(P＜0.05).Conclusion MRI regression pattern after neoadjuvant chemotherapy for triple-negative breast cancer is closely related to the pathological characteristics and prognosis of patients.MRI regression pattern has a good prognostic effect,and patients with MRI non-centripetal regression have a higher risk of poor prognosis.

Objective To investigate the MRI regression pattern and its relationship with prognosis in triple-negative breast cancer after neoadjuvant chemotherapy.Methods A total of 121 patients with triple-negative breast cancer were prospectively selected.All patients were given neoadjuvant chemotherapy and radical mastectomy.MRI was performed before and after neoadjuvant chemotherapy to observe their MRI regression pattern.Patients were followed up for 3 years to record their prognosis.The factors affecting prognosis of patients with triple-negative breast cancer after neoadjuvant chemotherapy were analyzed,and the MRI regression pattern and its relationship with prognosis were analyzed.Results MRI regression pattern after neoadjuvant chemotherapy was centripetal regression in 68 patients and non-centripetal regression in 53 patients(20 patients with fragmented regression and 33 patients with mixed regression).The MRI centripetal regression rate of triple-negative breast cancer patients with medium-high differentiation,stage Ⅱ,no lymph node metastasis and pathological complete response(pCR)was higher than that of patients with low differentiation,stage Ⅲ,with lymph node metastasis and no pCR,respectively(P＜0.05).Cox regression analysis showed that tumor stage,differentiation degree,pCR,MRI regression pattern were the factors affecting prognosis of triple-negative breast cancer patients after neoadjuvant chemotherapy(P＜0.05).Receiver operating characteristic(ROC)curve analysis results showed that the sensitivity of MRI regression pattern in predicting prognosis after neoadjuvant chemotherapy for triple-negative breast cancer patients was 84.62％,the specificity was 88.75％,and the area under the curve(AUC)was 0.870[95％confidence interval(CI)0.800-0.940].The disease-free survival curve of patients with MRI centripetal regression was better than that of patients with MRI non-centripetal regression(P＜0.05).Conclusion MRI regression pattern after neoadjuvant chemotherapy for triple-negative breast cancer is closely related to the pathological characteristics and prognosis of patients.MRI regression pattern has a good prognostic effect,and patients with MRI non-centripetal regression have a higher risk of poor prognosis.