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Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has spread around the world. However, approaches to distinguish COVID-19 from pneumonia caused by other pathogens have not yet been reported. We retrospectively analyzed the clinical data of 97 children with probable COVID-19. A total of 13 (13.4%) patients were confirmed positive for SARS-CoV-2 infection by nucleic acid RT-PCR testing, and 41 (42.3%) patients were found to be infected with other pathogens. Notably, no pathogen was detected in 43 (44.3%) patients. Among all patients, 25 (25.8%) had familial cluster exposure history, and 52 (53.6%) had one or more coexisting conditions. Fifteen (15.5%) patients were admitted or transferred to the PICU. In the 11 confirmed COVID-19 cases, 5 (45.5%) and 7 (63.6%) were positive for IgM and IgG against SARS-CoV-2, respectively. In 22 patients with suspected COVID-19, 1 (4.5%) was positive for IgG but negative for IgM. The most frequently detected pathogen was Mycoplasma pneumonia (29, 29.9%). One patient with confirmed COVID-19 died. Our results strongly indicated that the detection of asymptomatic COVID-19 or coexisting conditions must be strengthened in pediatric patients. These cases may be difficult to diagnose as COVID-19 unless etiologic analysis is conducted. A serologic test can be a useful adjunctive diagnostic tool in cases where SARS-CoV-2 infection is highly suspected but the nucleic acid test is negative.
Age Factors ; COVID-19/diagnosis* ; COVID-19 Testing ; Child ; Child, Preschool ; China ; Female ; Hospitalization ; Humans ; Infant ; Male ; Retrospective Studies ; SARS-CoV-2/isolation & purification* ; Symptom Assessment

7.TTSH and NCID Radiology Services in COVID-19.

Hsien Min LOW ; Eugene LOW ; Chau Hung LEE

Annals of the Academy of Medicine, Singapore 2020;49(11):913-914

8.Deployment of a Forward Medical Post to Provide Medical Support in a Purpose-built Dormitory during the COVID-19 Pandemic.

Guan Lin LEE ; Wei Ting LEE ; Wai Leong KOK

Annals of the Academy of Medicine, Singapore 2020;49(11):928-930

9.Environmental Monitoring of A Laboratory for New Coronavirus Nucleic Acid Testing.

Pei Yong NING ; Ai Ping YU ; Yuan WANG ; Li Ru GUO ; Dan SHAN ; Mei KONG ; Ling Qi YU ; Li Kun LYU ; Ming ZOU ; Xu SU ; Chun Nan FEI ; Yu Hui ZHOU ; Bai Qi WANG

Biomedical and Environmental Sciences 2020;33(10):771-774

10.Pulmonary Nodules Developed Rapidly in Staffs in the Isolation Ward of a Chinese Hospital during the COVID-19 Epidemic.

Yu Hua LI ; Ke Wen YU ; Neng Jun SUN ; Xiao Dong JIN ; Xin LUO ; Jing YANG ; Bing HE ; Bo LI

Biomedical and Environmental Sciences 2020;33(12):930-934

1.Genetic tracing of HCoV-19 for the re-emerging outbreak of COVID-19 in Beijing, China.

2.Re-detectable positive SARS-CoV-2 RNA tests in patients who recovered from COVID-19 with intestinal infection.

3.Positive RT-PCR detected in patients recovered from COVID-19.

4.Single cell RNA and immune repertoire profiling of COVID-19 patients reveal novel neutralizing antibody.

5.High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors.

6.Clinical manifestations and pathogen characteristics in children admitted for suspected COVID-19.

7.TTSH and NCID Radiology Services in COVID-19.

8.Deployment of a Forward Medical Post to Provide Medical Support in a Purpose-built Dormitory during the COVID-19 Pandemic.

9.Environmental Monitoring of A Laboratory for New Coronavirus Nucleic Acid Testing.

10.Pulmonary Nodules Developed Rapidly in Staffs in the Isolation Ward of a Chinese Hospital during the COVID-19 Epidemic.

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