In 2023, multiple international societies proposed the concept of metabolic-dysfunction and alcohol-associated liver disease (MetALD) to characterize patients with steatotic liver disease who exhibit metabolic dysfunction and consume alcohol at a moderate level. In recent years, the evidence system in this field has been constantly developed and improved. This article reviews the latest research advances in MetALD from the aspects of background, definition, epidemiological characteristics, natural history, clinical phenotype, diagnostic and assessment methods, and treatment regimens, as well as the directions for future investigation.