Heparin-binding protein (HBP) is a pro-inflammatory granule protein released by activated neutrophils, known for its role in modulating vascular permeability and its pathological significance in infectious diseases. In recent years, HBP has garnered attention due to its immune-activating effects in contexts such as sepsis, acute lung injury and organ transplantation. It has been proposed as a potential biomarker for early detection of infection and inflammation. While preliminary progress has been made in animal studies, clinical evidence remains limited. Therefore, this article focuses on the mechanism of action of HBP in transplantation-related complications, explores its potential pathways for predicting infection risk, mediating ischemia-reperfusion injury and rejection, and evaluates the feasibility of intervention strategies such as neutralizing antibodies, heparin derivatives and albumin. The pivotal role of HBP in regulating inflammatory responses post-transplant may offer a novel target for postoperative infection monitoring and personalized therapeutic interventions.

22 patients with acute myocardial infarction (AMI) under went early exercise testing (EET)(mean 12.50±4.39 days after MI) in our study. The positive rate of testing was 45.45%. The maximal ratepressure product (SBP×HR) and peak metabolic equivalent were 2782±776 bpm.kPa and 4.96 ±1.20METs. Following up 3 months to 2.5 years (1.33±0.84 years), we found that the occurrence of heart events in the positive EET group (EET-P) was more than in the negative EET group (EET-N) (X2=4.77, P<0.05).Time of return to work and housework in EET-P was earlier than EET-N. About time and ratio of return to work and housework, the EET group was higher and earlier than no EET(N-EET) group. On the other hand,sexual activity of EET was recovered to a certain degree and ma jority could do some physical training- The results would be showed that EET could improve the quality of life in the patients with AMI.