Objective:To investigate the efficacy and safety of transdermal triamcinolone acetonide delivery assisted by carbon dioxide dot matrix laser combined with narrow spectrum intense pulse laser in the treatment of keloid.Methods:A total of 82 patients with keloid in the Fifth Hospital of Huangshi City from March 2019 to March 2023 were retrospectively included and divided into two groups according to treatment methods. Combination group: 43 cases, including 20 males and 23 females, aged 20-55 (38.3±7.3) years, with a course of 3-8 (6.2±0.8) months, were treated with carbon dioxide dot matrix laser combined with narrow-spectrum intense pulse laser assisted transdermal administration of triamcinolone. Control group: 39 cases, including 23 males and 16 females, were treated with transdermal administration of triamcinolone acetonide alone, aged 21-54 (37.9±6.5) years, and the course of disease was 3-8 (6.2±0.7) months. Both groups were treated once a month for 9 months. The total effective rate, Vancouver scar scale score, bilateral scar assessment scale score, itching degree of scar, and incidence of adverse reactions were compared between the two groups after 9 months of treatment, and the cumulative recurrence rate of 12 and 24 months after treatment was assessed.Results:The total effective rate of the combined group was 93.0% (40/43), which was higher than that of the control group (76.9%) (30/39, P=0.014). After treatment, the color, vascular distribution, thickness, softness, total score and bidirectional scar assessment scale score of the combined group were lower than those of the control group, and the degree of scar itch was less than that of the control group (all P<0.05). The incidence of adverse reactions was 14.0% (6/43) in the combined group and 17.9% (7/39) in the control group, the difference was not statistically significant ( P=0.621). At 12 months after treatment, the recurrence rate was 4.7% (2/43) in the combination group and 5.1% (2/39) in the control group, with no statistical significance ( P=0.920). At 24 months after treatment, the recurrence rate in the combination group was 7.0% (3/43), lower than that in the control group (23.1%) (9/39, P=0.039). Conclusion:Carbon dioxide dot matrix laser combined with narrow spectrum intense pulse laser assisted transdermal triamcinolone acetonide in the treatment of keloid has a good effect, which can reduce the degree of scar itching, reduce recurrence, and do not increase adverse reactions.

Objective:To investigate the efficacy and safety of transdermal triamcinolone acetonide delivery assisted by carbon dioxide dot matrix laser combined with narrow spectrum intense pulse laser in the treatment of keloid.Methods:A total of 82 patients with keloid in the Fifth Hospital of Huangshi City from March 2019 to March 2023 were retrospectively included and divided into two groups according to treatment methods. Combination group: 43 cases, including 20 males and 23 females, aged 20-55 (38.3±7.3) years, with a course of 3-8 (6.2±0.8) months, were treated with carbon dioxide dot matrix laser combined with narrow-spectrum intense pulse laser assisted transdermal administration of triamcinolone. Control group: 39 cases, including 23 males and 16 females, were treated with transdermal administration of triamcinolone acetonide alone, aged 21-54 (37.9±6.5) years, and the course of disease was 3-8 (6.2±0.7) months. Both groups were treated once a month for 9 months. The total effective rate, Vancouver scar scale score, bilateral scar assessment scale score, itching degree of scar, and incidence of adverse reactions were compared between the two groups after 9 months of treatment, and the cumulative recurrence rate of 12 and 24 months after treatment was assessed.Results:The total effective rate of the combined group was 93.0% (40/43), which was higher than that of the control group (76.9%) (30/39, P=0.014). After treatment, the color, vascular distribution, thickness, softness, total score and bidirectional scar assessment scale score of the combined group were lower than those of the control group, and the degree of scar itch was less than that of the control group (all P<0.05). The incidence of adverse reactions was 14.0% (6/43) in the combined group and 17.9% (7/39) in the control group, the difference was not statistically significant ( P=0.621). At 12 months after treatment, the recurrence rate was 4.7% (2/43) in the combination group and 5.1% (2/39) in the control group, with no statistical significance ( P=0.920). At 24 months after treatment, the recurrence rate in the combination group was 7.0% (3/43), lower than that in the control group (23.1%) (9/39, P=0.039). Conclusion:Carbon dioxide dot matrix laser combined with narrow spectrum intense pulse laser assisted transdermal triamcinolone acetonide in the treatment of keloid has a good effect, which can reduce the degree of scar itching, reduce recurrence, and do not increase adverse reactions.

OBJECTIVE: To investigate the curative effects of nanometer silver dressing and recombinant bovine basic fibroblast growth factor gel on burn residual wounds.METHODS: Forty burn patients with residual wounds because of deep second degree burn and full-thickness burn, were randomly divided into control group and management group. There were 20 patients in both groups. The patients of management group were treated by nanometer silver dressing and recombinant bovine basic fibroblast growth factor gel. The patients of control group were treated by saline and paraffin absorbent gauze. Healing time, wound healing rates at different time points,cases of infected wound and results of bacterial culture before and 7 days following treatment, and drug adverse reaction were recorded.RESULTS: The healing time of management group was significantly shorter than the control group (P < 0.01). The wound healing rates of management group was significantly higher than the control group at different time points (P< 0.01). The cases of infected wound was significantly fewer than the control group after treating (P < 0.01). The pathogenic bacteria detection rate was significantly lower than the control group after 7 days (P < 0.01).CONCLUSION: There was better antibacterial activity, decurtating the healing time when the management of nanometer silver dressing and recombinant bovine basic fibroblast growth factor gel on burn residual wounds were put into practice.