Objective To explore application value of PDCA cycle method in intravenous( IV ) infusion speed management in inpatients. Methods Patients hospitalized in the 2nd ward of Department of Neurology,Peking University Third Hospital were selected as subjects and IV infusion speed standards were drown up using a quality improvement management,Plan-Do-Check-Action( PDCA)cycle method. Before and after the management,data related to IV infusion speeds from May 20th to 26th,2013( before management)and May 12th to 18th,2014( after management)and adverse drug reactions/events( ADR/ADE)evaluated absolutely,probably,or possibly related to drugs from August 2012 to May 2013( before management)and August 2013 to May 2014( after management)were collected,the qualified rates of IV infusion speeds and ADR/ADE rates were calculated. Results There were 40 beds of ward of department of Neurology. During May 20th to 26th ,2013,33 kinds of injections were used in patients(255 person-time),and 11 kinds of injections( belonged to 7 types,184 person-time)were selected as pilot injections for IV infusion speed management. The qualified rates of IV infusion speed were 82. 4%-100. 0% and the average IV infusion speed was 94. 6% ± 6. 7%. During May 12th to 18th ,2014,39 injections were used in patients(721 person-time). Among them,11 pilot injections were used in patients(483 person-time),the qualified rates of IV infusion speed were 85. 7%-100. 0% and the average IV infusion speed was 96. 6% ± 5. 1%. The qualified rate of IV infusion speed after IV infusion speed management increased than that before 05). A total of 145 cases of ADR/ADE which were evaluated absolutely,probably or possibly related to drugs were collected. Of them,49 cases of ADR/ADE were related to IV infusion speed,including 22 cases before IV infusion speed management(accounted for 36. 1% of 61 cases of ADR/ADE during the same time)and 27 cases after IV infusion speed management(accounted for 32. 1% of 84 cases of ADR/ADE during the same time). As for the ADR/ADE involved in 11 pilot injections, 3 cases occurred before management (accounted for 4. 9% of 61 cases of ADR/ADE during the same time)and 4 cases occurred after management( accounted for 4. 7% of 84 cases of ADR/ADE during the same time). Conclusion Application of PDCA cycle method may improve quality of IV infusion speed management in inpatients and increase medication safety management level.

Objective To explore application value of PDCA cycle method in intravenous( IV ) infusion speed management in inpatients. Methods Patients hospitalized in the 2nd ward of Department of Neurology,Peking University Third Hospital were selected as subjects and IV infusion speed standards were drown up using a quality improvement management,Plan-Do-Check-Action( PDCA)cycle method. Before and after the management,data related to IV infusion speeds from May 20th to 26th,2013( before management)and May 12th to 18th,2014( after management)and adverse drug reactions/events( ADR/ADE)evaluated absolutely,probably,or possibly related to drugs from August 2012 to May 2013( before management)and August 2013 to May 2014( after management)were collected,the qualified rates of IV infusion speeds and ADR/ADE rates were calculated. Results There were 40 beds of ward of department of Neurology. During May 20th to 26th ,2013,33 kinds of injections were used in patients(255 person-time),and 11 kinds of injections( belonged to 7 types,184 person-time)were selected as pilot injections for IV infusion speed management. The qualified rates of IV infusion speed were 82. 4%-100. 0% and the average IV infusion speed was 94. 6% ± 6. 7%. During May 12th to 18th ,2014,39 injections were used in patients(721 person-time). Among them,11 pilot injections were used in patients(483 person-time),the qualified rates of IV infusion speed were 85. 7%-100. 0% and the average IV infusion speed was 96. 6% ± 5. 1%. The qualified rate of IV infusion speed after IV infusion speed management increased than that before 05). A total of 145 cases of ADR/ADE which were evaluated absolutely,probably or possibly related to drugs were collected. Of them,49 cases of ADR/ADE were related to IV infusion speed,including 22 cases before IV infusion speed management(accounted for 36. 1% of 61 cases of ADR/ADE during the same time)and 27 cases after IV infusion speed management(accounted for 32. 1% of 84 cases of ADR/ADE during the same time). As for the ADR/ADE involved in 11 pilot injections, 3 cases occurred before management (accounted for 4. 9% of 61 cases of ADR/ADE during the same time)and 4 cases occurred after management( accounted for 4. 7% of 84 cases of ADR/ADE during the same time). Conclusion Application of PDCA cycle method may improve quality of IV infusion speed management in inpatients and increase medication safety management level.

Objective To investigate the therapeutic effects and mechanism of anti-radiation pneumonia decoction(ARPD) on radiation induced lung fibrosis in rats.Methods One hundred and five male SD rats in a SPF grade were divided into Chinese medicine group,single radiation group and control group by random digits table method,with 35 in each group.After anesthetization,rats in Chinese medicine and single radiation groups were exposed to 6 MV X-rays at the dose of 15Gy.Rats in Chinese medicine group were treated with ARPD at the dosage of 10 ml·kg-1 ·d-1 once a day,but rats in single radiation group did not receive ARPD treatment.Rats in control group were treated with neither irradiation nor drugs.Five rats of each group were killed and the lung tissues and blood samples were collected at 15,30,60,75,90,105 and 140 d.The pathological changes of lung tissues were observed and the tissue protein and gene expressions of TGF-β1,PAI-1 and collagen type Ⅲ(C Ⅲ) were assayed by Western blot and RT-PCR.ELISA was used to detect serum TGF-β1 and plasma PAI-1.Tissue and serum HYP were determined by acid hydrolysis and alkaline hydrolysis methods respectively.Results Inflammation was found in the lung tissues of all the exposed rats.Obvious pathological lung fibrosis was found at 60 d,the inflammation and the fibrosis in treated group were slighter than those in single radiation group.In Chinese medicine group,the protein and gene expression levels of TGF-β1,PAI-1,C Ⅲ 30 d(Protein:t =2.49-3.74,t =2.63-4.57 and t =2.76-3.83;Gene:t =2.59-4.33,t =2.83-4.62 and t =2.83-3.96,P＜0.05),serum TGF-β1 and plasma PAI-1 15 dlater (t =2.85-6.27 and t =3.69-5.27,P＜0.05),and the levels of tissue and serum HYP60 dlater (t=3.65-4.40 and t =6.56-3.75,P＜0.05),all of them were lower than those in single radiation groups.There were significant positive correlations between tissue TGF-β1 and PAI-1 as well as C Ⅲ (Protein expression:r =0.604,0.759,P ＜0.05;Gene expression:r=0.519,0.816,P＜0.05).Conclusions ARPD may inhibit the pulmonary fibrosis by decreasing the levels of TGF-β1,PAI-1 and C Ⅲ.