Objective:To explore the bidirectional relationship between adaptability and insomnia symptoms in college students.Methods:A longitudinal study was conducted across three phases over a span of two years,invol-ving a sample of 13 861 students from a comprehensive university in Shandong Province.The Adaptability Scale(APAS)and the Insomnia Symptoms Scale(ISI)were used to measure adaptability and insomnia symptoms,re-spectively.A latent variable structural equation model was applied to assess the cross-lagged associations between a-daptability and insomnia symptoms over time.Results:The Baseline APAS scores negatively predicted the ISI scores one year later(β=-0.05,P＜0.001),and the APAS scores at one year negatively predicted the ISI scores at the two-year mark(β=-0.04,P＜0.001).Similarly,the baseline ISI scores negatively predicted the APAS scores one year later(β=-0.06,P＜0.001),and the ISI scores at one year negatively predicted the APAS scores two years later(β=-0.03,P＜0.01).Conclusion:The study demonstrates that adaptability helps prevent insom-nia symptoms in students,while insomnia negatively impacts students'adaptability.

Objective:To explore the bidirectional relationship between adaptability and insomnia symptoms in college students.Methods:A longitudinal study was conducted across three phases over a span of two years,invol-ving a sample of 13 861 students from a comprehensive university in Shandong Province.The Adaptability Scale(APAS)and the Insomnia Symptoms Scale(ISI)were used to measure adaptability and insomnia symptoms,re-spectively.A latent variable structural equation model was applied to assess the cross-lagged associations between a-daptability and insomnia symptoms over time.Results:The Baseline APAS scores negatively predicted the ISI scores one year later(β=-0.05,P＜0.001),and the APAS scores at one year negatively predicted the ISI scores at the two-year mark(β=-0.04,P＜0.001).Similarly,the baseline ISI scores negatively predicted the APAS scores one year later(β=-0.06,P＜0.001),and the ISI scores at one year negatively predicted the APAS scores two years later(β=-0.03,P＜0.01).Conclusion:The study demonstrates that adaptability helps prevent insom-nia symptoms in students,while insomnia negatively impacts students'adaptability.

OBJECTIVE:To determine the contents of chloromycetin and dexamethasone acetate in Jiefu cream.METHODS:A reversed-phase HPLC was established for the determination with C18 column as stationary phase.The mobile phase consisted of acetonitrile and 0.05%mol/L phosphate buffer solution(40∶60),the detection wavelength was 240nm.RESULTS:Chlorom-ycetin had a good linearity (r=0.9 998) in the range of 0.1～0.3mg/ml,the mean recovery was 100.6% with a RSD of 1.3%.Dexamethasone acetate had a good linearity(r=0.9 998) in the range of 0.02～0.08mg/ml,the mean recovery was 101.1% with a RSD of 1.7%.CONCLUSION:The method is simple,sensitive and accurate.