[Objective]To explore Professor XU Guangxing's experience in differentiating and treating gastric cancer based on the"Yangming Weihe(stomach closed)"theory.[Methods]Through clinical shadowing,organizing and analyzing medical cases,and studying relevant literature,combined with Professor XU Guangxing's understanding of gastric cancer,this paper summarizes his experience in differentiating and treating gastric cancer based on the"Yangming Weihe"theory from the perspectives of theoretical connotation,etiology,pathogenesis and medication strategies.A medical case is included for validation.[Results]The theory of"Yangming Weihe"originates from the opening-closing-pivot theory.The Yangming closing mechanism serves as a component of the ascending and descending movement of Qi in the human body.Together with the Taiyin opening mechanism and the Jueyin closing mechanism,it collectively regulates the physiological functions of the stomach.Professor XU Guangxing proposes that the etiology and pathogenesis of gastric cancer can be categorized into three patterns:dysfunction of the Yangming closing mechanism;impaired Taiyin-Yangming opening-closing coordination;dual dysfunction of the Jueyin-Yangming closing mechanisms.His therapeutic strategies focus on:clearing heat,moistening dryness and promoting descending with bitter flavors to unblock Yangming;strengthening the spleen and harmonizing the middle-Jiao to support the opening-closing mechanism;dispersing wind pathogens and consolidating dissipation to restore the dual closing mechanisms.The attached medical case involved a postoperative gastric cancer patient,diagnosed as dual Jueyin-Yangming closing mechanism failure according to the"Yangming Weihe"theory.The treatment protocol emphasized:clearing dryness,nourishing Yin and unblocking-tonifying Yangming;dispersing wind,astringing dissipation and consolidating-descending Jueyin.The herbal regimen achieved stable and positive outcomes.[Conclusion]Professor XU Guangxing's approach to treating gastric cancer based on the"Yangming weihe"theory is characterized by unique insights into the etiology and pathogenesis,distinctive features in syndrome differentiation and treatment,and notable clinical efficacy.This methodology merits further research and broader promotion.

[Objective]To explore the academic characteristics of SHI Fa's On Continuation of Simple Formulas,the backbone physician of Yongjia medical school,and enrich the research on the academic thought of Yongjia medical school.[Methods]By using the method of literature research,through the study of On Continuation of Simple Formulas and other works of Yongjia medical school,combined with modern related research literature,this paper analyzes and sorts out the background,compilation principles and academic characteristics of On Continuation of Simple Formulas,and verifies it with medical cases.[Results]SHI Fa inherited the academic thoughts of CHEN Yan,the founder of Yongjia medical school,and his great disciple WANG Shuo,and corrected the oversimplification of Simple Formulas,"There is no difference between deficiency,excess,cold and heat syndromes,and one party governs one disease".Starting from clinical application,he not only pursued simplicity,but also pursued practicality.He abided by the principle of syndrome differentiation and treatment,adhered to the principle of pulse first and combination of pulse and disease,emphasized the protection of stomach Qi and the treatment of three causes,and advocated familiarity with medicinal properties and medication according to syndrome.The attached medical cases fully verified the fallacy of WANG Shuo's"one party governs all the syndromes"and the correctness of the academic characteristics of syndrome differentiation and treatment and addition and subtraction with the syndrome.[Conclusion]On Continuation of Simple Formulas attaches importance to the academic characteristics of syndrome differentiation,combination of pulse and disease,careful medication and protection of stomach Qi,which enriches the academic thought of Yongjia medical school and promotes the inheritance and development of Yongjia medical school.It also has enlightening significance for today's clinical diagnosis and treatment.

[Objective]To explore Professor XU Guangxing's experience in differentiating and treating gastric cancer based on the"Yangming Weihe(stomach closed)"theory.[Methods]Through clinical shadowing,organizing and analyzing medical cases,and studying relevant literature,combined with Professor XU Guangxing's understanding of gastric cancer,this paper summarizes his experience in differentiating and treating gastric cancer based on the"Yangming Weihe"theory from the perspectives of theoretical connotation,etiology,pathogenesis and medication strategies.A medical case is included for validation.[Results]The theory of"Yangming Weihe"originates from the opening-closing-pivot theory.The Yangming closing mechanism serves as a component of the ascending and descending movement of Qi in the human body.Together with the Taiyin opening mechanism and the Jueyin closing mechanism,it collectively regulates the physiological functions of the stomach.Professor XU Guangxing proposes that the etiology and pathogenesis of gastric cancer can be categorized into three patterns:dysfunction of the Yangming closing mechanism;impaired Taiyin-Yangming opening-closing coordination;dual dysfunction of the Jueyin-Yangming closing mechanisms.His therapeutic strategies focus on:clearing heat,moistening dryness and promoting descending with bitter flavors to unblock Yangming;strengthening the spleen and harmonizing the middle-Jiao to support the opening-closing mechanism;dispersing wind pathogens and consolidating dissipation to restore the dual closing mechanisms.The attached medical case involved a postoperative gastric cancer patient,diagnosed as dual Jueyin-Yangming closing mechanism failure according to the"Yangming Weihe"theory.The treatment protocol emphasized:clearing dryness,nourishing Yin and unblocking-tonifying Yangming;dispersing wind,astringing dissipation and consolidating-descending Jueyin.The herbal regimen achieved stable and positive outcomes.[Conclusion]Professor XU Guangxing's approach to treating gastric cancer based on the"Yangming weihe"theory is characterized by unique insights into the etiology and pathogenesis,distinctive features in syndrome differentiation and treatment,and notable clinical efficacy.This methodology merits further research and broader promotion.

[Objective]To explore the academic characteristics of SHI Fa's On Continuation of Simple Formulas,the backbone physician of Yongjia medical school,and enrich the research on the academic thought of Yongjia medical school.[Methods]By using the method of literature research,through the study of On Continuation of Simple Formulas and other works of Yongjia medical school,combined with modern related research literature,this paper analyzes and sorts out the background,compilation principles and academic characteristics of On Continuation of Simple Formulas,and verifies it with medical cases.[Results]SHI Fa inherited the academic thoughts of CHEN Yan,the founder of Yongjia medical school,and his great disciple WANG Shuo,and corrected the oversimplification of Simple Formulas,"There is no difference between deficiency,excess,cold and heat syndromes,and one party governs one disease".Starting from clinical application,he not only pursued simplicity,but also pursued practicality.He abided by the principle of syndrome differentiation and treatment,adhered to the principle of pulse first and combination of pulse and disease,emphasized the protection of stomach Qi and the treatment of three causes,and advocated familiarity with medicinal properties and medication according to syndrome.The attached medical cases fully verified the fallacy of WANG Shuo's"one party governs all the syndromes"and the correctness of the academic characteristics of syndrome differentiation and treatment and addition and subtraction with the syndrome.[Conclusion]On Continuation of Simple Formulas attaches importance to the academic characteristics of syndrome differentiation,combination of pulse and disease,careful medication and protection of stomach Qi,which enriches the academic thought of Yongjia medical school and promotes the inheritance and development of Yongjia medical school.It also has enlightening significance for today's clinical diagnosis and treatment.

Objective To establish and validate a Nomogram model for predicting the overall survival(OS)of the patients with intrahepatic cholangiocarcinoma(ICC)based on domestic multicenter data,and screen the beneficiaries of adjuvant chemotherapy based on the prediction model.Methods From December 2011 to December 2017,the data of 278 patients with postoperative pathological diagnosis of ICC from 4 medical centers in our country were collected retrospectively COX regression model was used to screen the independent risk factors of OS and constructed a Nomogram model.This model was used to stratify the risk of OS for all patients and to screen the beneficiaries of adjuvant chemotherapy.Results A total of 278 patients were enrolled,and 23 cases(8.3%)received adjuvant chemotherapy.COX multivariate analysis showed that drinking history,ECOG score,method of hepatectomy,lymph node status,number of tumors,and tumor differentiation were independent risk factors for postoperative OS.The Nomogram model had a C-index of 0.690(95%CI:0.646-0.734)in the training cohort and 0.740(95%CI:0.863-0.617)in the validation cohort.According to risk stratification by Nomogram model,in the high-risk group there was a statistically significant difference in survival between adjuvant chemotherapy and non-adjuvant chemotherapy(P=0.033),whereas in the low-risk group,there was no significant difference in survival(P=0.59).Conclusions Nomogram model based on independent risk factors of OS demonstrated excellent predictive capability for survival and could be used to screen,and identify the patients with ICC who benefit from adjuvant chemotherapy.