Objective To explore the relationship between surgical treatment combined with drug therapy and the recovery of hepatic function following tumor resection of primary liver cancer ( PLC) , and to provide reasonable recommendations for clinical treat-ment of the disease .Methods One hundred and twenty cases , which were diagnosed as primary liver cancer and given tumor resection from January 2009 to December 2010 in our hospital were selected and analyzed retrospectively .There were 82 cases that had complete records and could be used for effective analysis .Based on "the China National Formulary"(2010) and the mechanism of drugs , hepa-to-protectants were divided into 6 categories:⑴A=anti-inflammatory drug , B=membrane system stabilizing drug , C=combined de-toxification drug, D=enhanced energy supply drug, E=regeneration promotion drug and F =the category of other drugs.Results (1) When the A+D treatment profile was compared with the C +D treatment profile, the k value of total bilirubin (TB) was P=0.046 and the k value of aspartate aminotransferase (AST) was P=0.035.The C+D treatment profile was superior to that of the A +D treatment profile.(2) Positive correlation could be noted between the k values of ALT and AST (P<0.01).(3) The k value of TB and AST were negatively correlated with the blocking time of portal vein , cirrhosis type and other variables .Conclusion After tumor resection of the primary liver cancer , the C +D treatment profile was superior to the A +D treatment profile in enhancing recovery of hepatic function .