Interstitial lung disease is a common lung disease of connective tissue disease,which seriously affects the survival rate and quality of life of patients with connective tissue disease.Interstitial lung disease may occur in the whole course of connective tissue disease.Therefore,imaging plays an important role in the whole disease cycle of connective tissue-associated interstitial lung disease.At present,high-resolution computed tomography is the cornerstone of screening,diagnosis and follow-up of connective tissue-associated interstitial lung disease,but ionizing radiation is a potential limiting factor in its clinical application.In recent years,new imaging techniques have developed rapidly,and some promising research results have been achieved in the early screening,diagnosis and efficacy evaluation of connective tissue-associated interstitial lung disease,and they are gradually moving towards non-invasive,low-radiation and accurate imaging analysis techniques.This article reviews the advances in imaging research of connective tissue-associated interstitial lung disease,and analyzes the advantages and disadvantages of various new imaging techniques,as well as the challenges and prospects.

Objective:To explore the protective effect and underlying mechanism of hyperbaric oxygen (HBO) on delayed encephalopathy after carbon monoxide poisoning (DEACMP) in mice.Methods:Totally 225 adult male Kunming mice were selected to establish CO poisoning model via intraperitoneal injection carbon monoxide (CO), and were randomly divided into the air control group, CO poisoning group, and HBO group. Each group was further divided into five time points group, that was 1, 3, 7, 14 and 21 d. The mice in the air control group were injected intraperitoneally with the same amount of air, and the HBO group received HBO treatment at the same time every day. DEACMP mice model was screened by behaviors using the open field test, new object recognition test and nesting test, and the content of myelin basic protein (MBP) were assayed. The mouse brain tissue and mitochondrial were prepared and malonialdehyde (MDA) and adenosine triphosphate (ATP) content were measured with ultraviolet spectrophotometer. MBP content in brain tissue and cytochrome C (CytC) content in the mitochondrial were measured by ELISA. The mitochondria membrane potential (MMP) was measured by flow cytometry.Results:Compared with the air control group, the content of carboxyhemoglobin (COHB) in blood increased significantly and the content of MBP in brain tissue decreased significantly in CO poisoning mice. CO poisoning mice showed motor ability and cognitive dysfunction. Compared with the air control group, the contents of MMP, CytC and ATP were significantly decreased ( P<0.01) in the CO poisoning group; while the MDA content was significantly increased ( P<0.01). Compared with the CO poisoning group, mice behaviors were improved significantly ( P<0.05), the content of MBP, MMP, CytC and ATP were increased ( P<0.05), while the MDA content decreased significantly ( P<0.01) in the HBO group. Conclusions:The abnormal mitochondrial function might be closely related to the occurrence and development of DEACMP, and HBO therapy plays an effective role in preventing and treating the DEACMP mice model via the mitochondrial pathway.

Objective To observe the therapeutic effects of hyperbaric oxygen ( HBO) on sleep disorders induced by different diseases , so as to provide evidence for diagnosis and treatment of such disorders . Methods Fifty-five patients with sudden inductive neural hearing loss and 63 patients with stroke and traumatic brain injury who received treatment in the hospital were recruited as research subjects .In accordance with treatment methods, the patients were divided into the HBO group and the routine treatment group or the control group.The patients of the 2 groups were given the same drug treatment , except that the patients of the HBO group received HBO therapy, one session a day.After one course of treatment, sleep quality in the patients of the 2 groups were evaluated by Pittsburgh sleep quality index (PSQI).Results T-test revealed that sleep quality of the patients with sudden inductive neural hearing loss , stroke and traumatic brain injury in the 2 groups after therapy was all superior to that before therapy (P <0.05).At the same time, 2 independent sample t-test indicated that scores of sleep efficiency , sleep disorder, daytime function and demand for hypnotic drug in the patients with inductive neural hearing loss after HBO treatment (8.93 ±2.29)were all superior to those of the control group patients (11.26 ±2.35), and statistical significance could be seen when comparisons were made between the patients of the 2 groups(P <0.05).Following HBO therapy, the patients with stroke and traumatic brain injury after HBO treatment showed little improvement in daytime function , however, other scores (11.21 ±1.76) were all superior to those of the control group (13.56 ±1.30), also with statistical significance(P <0.05).Conclusions HBO could improve sleep disturbance induced by sudden inductive neural hearing loss, stroke and traumatic brain injury.

Objective To observe the therapeutic effects of hyperbaric oxygen ( HBO) on sleep disorders induced by different diseases , so as to provide evidence for diagnosis and treatment of such disorders . Methods Fifty-five patients with sudden inductive neural hearing loss and 63 patients with stroke and traumatic brain injury who received treatment in the hospital were recruited as research subjects .In accordance with treatment methods, the patients were divided into the HBO group and the routine treatment group or the control group.The patients of the 2 groups were given the same drug treatment , except that the patients of the HBO group received HBO therapy, one session a day.After one course of treatment, sleep quality in the patients of the 2 groups were evaluated by Pittsburgh sleep quality index (PSQI).Results T-test revealed that sleep quality of the patients with sudden inductive neural hearing loss , stroke and traumatic brain injury in the 2 groups after therapy was all superior to that before therapy (P <0.05).At the same time, 2 independent sample t-test indicated that scores of sleep efficiency , sleep disorder, daytime function and demand for hypnotic drug in the patients with inductive neural hearing loss after HBO treatment (8.93 ±2.29)were all superior to those of the control group patients (11.26 ±2.35), and statistical significance could be seen when comparisons were made between the patients of the 2 groups(P <0.05).Following HBO therapy, the patients with stroke and traumatic brain injury after HBO treatment showed little improvement in daytime function , however, other scores (11.21 ±1.76) were all superior to those of the control group (13.56 ±1.30), also with statistical significance(P <0.05).Conclusions HBO could improve sleep disturbance induced by sudden inductive neural hearing loss, stroke and traumatic brain injury.

Objective To investigate the therapeutic effect and side effect of prourokinase (Pro-uk) on the patients with acute myocardial infarction. Method From May 2004 to May 2005, a total of 68 cases of acute myocardial infarction treated by thrombolytic agents within 6 hours after onset were divided randomly into Pro-uk group ( n = 43) and urokinase (UK) group ( re = 25). In the Pro- uk group, there were 22 eases treated with 50 mg Pro-uk and 21 cases prescribed in 60 mg Pro-uk. The patency of involved coronary artery was evaluated by using selective coronary angiography at 90 minutes after thrombolytic therapy. The incidence of early heart events, bleeding and adverse reaction, were alse observed. Results (1) The total rates of resumed patency of obstructed coronary artery (TIMI grade 2 and 3 flow) were 76.7% in Pro-uk treated patients and 52.2% in UK treated patient ( P = 0. 041). (2) The occurrence of hyporrhea was lowered more significantly in Pro-uk treated patients than in UK treated patients (P = 0.029), but there were no intracranial hemorrhage found in both group. (3) Early cardiac events and adverse reactions were similar between two groups. Conclusions Pro-UK is safe and effective for the patients with acute myocardial infarction.