Objective:To explore the teaching reform of the Food Analysis experiment course under the concept of employment-oriented education,and to improve students'practical ability and employment competitiveness.Methods:Taking students majoring in Food Quality and Safety at a certain university as the research objects,the control group adopted traditional teaching,while the experimental group carried out reforms by optimizing the curriculum system,innovating the teaching mode,and establishing a diversified evaluation system.The total scores,teaching effectiveness,satisfaction with the teaching mode,and the evaluation of graduates by employers between the two groups were compared.Results:The average total score of the experimental group was significantly higher than that of the control group(P＜0.05).The teaching effect evaluations of the experimental group in improving experimental operation skills and enhancing employment position cognition were all higher than those of the control group(P＜0.05).The satisfaction of the experimental group with the teaching mode was better than that of the control group(P＜0.05).In the evaluation results of employers on graduates,the excellent rate of the experimental group was significantly higher than that of the control group(P＜0.01).Conclusion:The reform measures effectively improve the teaching quality and students'comprehensive literacy,and deliver high-quality talents with both practical ability and innovative thinking to the food industry.

Objective:To explore the correlation between elderly education and health status of elderly people in urban and rural areas.Methods:A cross-sectional survey was conducted from Jul 2024 to Dec 2024 involving 200 elderly people aged 60 and above in Shenyang.Among them,62 participated in elderly education and 138 did not.The psychological and health status of the two groups were evaluated using the Satisfaction with Life Scale(SWLS),Hamilton Anxiety and Depression Scale,Montreal Cognitive Assessment Scale,and a self-designed questionnaire on health status.Results:There were statistically significant differences in age,years of education,occupation(before retirement),living conditions,and residential location between the two groups(P＜0.05).There were statistically significant differences in life satisfaction,delayed recall ability,and occurrence of physical limitations between the two groups(P＜0.05).Conclusion:Conducting elderly education for the elderly population is of great significance in promoting their physical and mental health,promoting the construction of a positive aging concept,and establishing a comprehensive elderly health system.

Objective:To explore the correlation between elderly education and health status of elderly people in urban and rural areas.Methods:A cross-sectional survey was conducted from Jul 2024 to Dec 2024 involving 200 elderly people aged 60 and above in Shenyang.Among them,62 participated in elderly education and 138 did not.The psychological and health status of the two groups were evaluated using the Satisfaction with Life Scale(SWLS),Hamilton Anxiety and Depression Scale,Montreal Cognitive Assessment Scale,and a self-designed questionnaire on health status.Results:There were statistically significant differences in age,years of education,occupation(before retirement),living conditions,and residential location between the two groups(P＜0.05).There were statistically significant differences in life satisfaction,delayed recall ability,and occurrence of physical limitations between the two groups(P＜0.05).Conclusion:Conducting elderly education for the elderly population is of great significance in promoting their physical and mental health,promoting the construction of a positive aging concept,and establishing a comprehensive elderly health system.

Objective:To explore the teaching reform of the Food Analysis experiment course under the concept of employment-oriented education,and to improve students'practical ability and employment competitiveness.Methods:Taking students majoring in Food Quality and Safety at a certain university as the research objects,the control group adopted traditional teaching,while the experimental group carried out reforms by optimizing the curriculum system,innovating the teaching mode,and establishing a diversified evaluation system.The total scores,teaching effectiveness,satisfaction with the teaching mode,and the evaluation of graduates by employers between the two groups were compared.Results:The average total score of the experimental group was significantly higher than that of the control group(P＜0.05).The teaching effect evaluations of the experimental group in improving experimental operation skills and enhancing employment position cognition were all higher than those of the control group(P＜0.05).The satisfaction of the experimental group with the teaching mode was better than that of the control group(P＜0.05).In the evaluation results of employers on graduates,the excellent rate of the experimental group was significantly higher than that of the control group(P＜0.01).Conclusion:The reform measures effectively improve the teaching quality and students'comprehensive literacy,and deliver high-quality talents with both practical ability and innovative thinking to the food industry.

Objective To construct a key nursing technology system for the treatment of patients exposed to nuclear radiation in hospitals,and provide technical guidance and support for emergency nursing rescue in hospitals of nuclear radiation accidents.Methods A research group was composed of a team with rich experience in nuclear radiation accidents.Based on 4 scenarios of nuclear radiation accidents(including external irradiation,internal irradiation,external contamination,internal contamination),the literature search was conducted to form the first draft of the system.Delphi method was used to complete 2 rounds of expert letter consultation,and the final draft of the key nursing technology system for hospital treatment of patients with nuclear radiation exposure was constructed according to the revised opinions of experts.Results A total of 16 experts completed 2 rounds of correspondence.The effective recovery rates were 100％and 80％;the recommendation rates were 65％and 50％;the authority coefficients(Cr)were 0.778 and 0.797;the coefficient of variation(CV)of the 2 rounds of expert letter consultation was ≤0.25.Finally,a key nursing technology system for in-hospital treatment of patients with nuclear radiation exposure was formed,including 5 first-level indicators,26 second-level indicators and 74 third-level indicators.Conclusion The constructed key nursing technology system for hospital treatment of patients with nuclear radiation exposure is highly practical and scientific,and it is conducive to the formation of standardized nuclear radiation exposure treatment procedures,and provides a theoretical basis for the training and evaluation of nursing staff related to nuclear radiation exposure.

With the continuous deepening of China's aging population,it is necessary to promote elderly disease prevention services,strengthen the construction of elderly medical resources,cultivate a team of service talents,and comprehensively improve elderly health service capabilities.The health support system for the elderly should be continuously improved through the combination of medical care and elderly care,smart elderly care,and elderly education.These measures are of great significance for actively coping with population aging

The development of acute liver injury can result in liver cirrhosis, liver failure, and even liver cancer, yet there is currently no effective therapy for it. The purpose of this study was to investigate the protective effect and therapeutic mechanism of Lyciumbarbarum polysaccharides (LBPs) on acute liver injury induced by carbon tetrachloride (CCl₄). To create a model of acute liver injury, experimental canines received an intraperitoneal injection of 1 mL/kg of CCl₄ solution. The experimental canines in the therapy group were then fed LBPs (20 mg/kg). CCl₄-induced liver structural damage, excessive fibrosis, and reduced mitochondrial density were all improved by LBPs, according to microstructure data. By suppressing Kelch-like epichlorohydrin (ECH)-associated protein 1 (Keap1), promoting the production of sequestosome 1 (SQSTM1)/p62, nuclear factor erythroid 2-related factor 2 (Nrf2), and phase II detoxification genes and proteins downstream of Nrf2, and restoring the activity of anti-oxidant enzymes like catalase (CAT), LBPs can restore and increase the antioxidant capacity of liver. To lessen mitochondrial damage, LBPs can also enhance mitochondrial respiration, raise tissue adenosine triphosphate (ATP) levels, and reactivate the respiratory chain complexes I‒V. According to serum metabolomics, the therapeutic impact of LBPs on acute liver damage is accomplished mostly by controlling the pathways to lipid metabolism. 9-Hydroxyoctadecadienoic acid (9-HODE), lysophosphatidylcholine (LysoPC/LPC), and phosphatidylethanolamine (PE) may be potential indicators of acute liver injury. This study confirmed that LBPs, an effective hepatoprotective drug, may cure acute liver injury by lowering oxidative stress, repairing mitochondrial damage, and regulating metabolic pathways.
Animals ; Dogs ; Antioxidants/metabolism* ; Carbon Tetrachloride ; Chemical and Drug Induced Liver Injury/drug therapy* ; Kelch-Like ECH-Associated Protein 1/metabolism* ; Liver ; Metabolic Networks and Pathways ; Mitochondria/metabolism* ; NF-E2-Related Factor 2/metabolism* ; Oxidative Stress ; Polysaccharides/pharmacology* ; Lycium/chemistry*

Objective Optimizing the extraction process of prescription medicinal materials of hospital preparation of compound Yangshe granules. Methods A high performance liquid chromatograph (HPLC) quantitative method was established for deacetyl asperulosidicacid methyl ester (DME) and ferulic acid (FC) of the active ingredient. Based on the content of DME, FC and the yield of extract, the extraction process of compound Yangshe granule extract was optimized using central composite design-response surface methodology. Results The established HPLC method of quantification of active components in compound Yangshe granules met the requirements of method validation. The optimal extraction process optimized by central composite design-response surface methodology were as follows: the weight of extraction solvent was 12 times of the medicinal slices, the alcohol concentration was 73% and the extraction time was 60 min. Conclusion In this study, the quantitative method of active components in compound Yangshe granule by HPLC has been successfully established, and the optimized extraction process is simple and easy to operate with good repeatability.

Objective:To establish a competency assessment system for nutritional support specialist nurses, so as to provide reference basis for training reform, functional performance, and improvement of nursing service quality for nutritional support specialist nurses.Methods:Based on the practice standards of nutrition support specialist nurses published by American Society for Parenteral and Enteral Nutrition, the draft of the competency assessment system for nutrition support specialist nurses was developed through literature search and group discussion. From November 2021 to February 2022, two rounds of expert letter consultation were conducted with 15 experts by Delphi method, indicators were screened and modified according to expert suggestions, and the final competency assessment system for nutrition support specialist nurses was formed.Results:The effective response rates of the two rounds of expert inquiry questionnaires were 93.3% (14/15) and 100.0% (15/15) , with expert authority coefficients of 0.922 and 0.917, respectively. In the first round of expert consultation, 50.0% (3/6) of the first-level indicators agreed with a percentage≥80.0%, and 64.9% (24/37) of the second-level indicators agreed with a percentage≥80.0%. In the second round of expert letter consultation, the agreement percentage of the first and second indicators were≥80.0%. The final competency assessment system for nutrition support specialist nurses included 6 first-level indicators (practical ability, communication and coordination ability, education and consultation ability, legal and ethical decision-making ability, scientific research ability, leadership) and 29 second-level indicators.Conclusions:The competency assessment system for nutritional support specialist nurses constructed in this study is scientific, reasonable, and highly reliable, which can be used to standardize the training process of nutritional support specialist nurses, promote personal development.

The development of acute liver injury can result in liver cirrhosis, liver failure, and even liver cancer, yet there is currently no effective therapy for it. The purpose of this study was to investigate the protective effect and therapeutic mechanism of Lycium barbarum polysaccharides (LBPs) on acute liver injury induced by carbon tetrachloride (CCl4). To create a model of acute liver injury, experimental canines received an intraperitoneal injection of 1 mL/kg of CCl4 solution. The experimental canines in the therapy group were then fed LBPs (20 mg/kg). CCl4-induced liver structural damage, excessive fibrosis, and reduced mitochondrial density were all improved by LBPs, according to microstructure data. By suppressing Kelch-like epichlorohydrin (ECH)-associated protein 1 (Keap1), promoting the production of sequestosome 1 (SQSTM1)/p62, nuclear factor erythroid 2-related factor 2 (Nrf2), and phase Ⅱ detoxification genes and proteins downstream of Nrf2, and restoring the activity of anti-oxidant enzymes like catalase (CAT), LBPs can restore and increase the antioxidant capacity of liver. To lessen mitochondrial damage, LBPs can also enhance mitochondrial respiration, raise tissue adenosine triphosphate (ATP) levels, and reactivate the respiratory chain complexes I?V. According to serum metabolomics, the therapeutic impact of LBPs on acute liver damage is accomplished mostly by controlling the pathways to lipid metabolism. 9-Hydroxyoctadecadienoic acid (9-HODE), lysophosphatidylcholine (LysoPC/LPC), and phosphatidylethanolamine (PE) may be potential indicators of acute liver injury. This study confirmed that LBPs, an effective hepatoprotective drug, may cure acute liver injury by lowering oxidative stress, repairing mitochondrial damage, and regulating metabolic pathways.