Background: Early stage ovarian cancer may be managed with fertility-sparing surgery, to preserve the uterus and contralateral ovary, thus preserving future reproductive function. The aim of this study was to determine the reproductive outcome of early stage ovarian cancer managed conservatively by unilateral salpingooophorectomy, and to compare the survival and recurrence rate among those who had and did not have pregnancy after treatment. Methodology:: A retrospective cohort study was conducted on 34 patients with early stage ovarian cancer who underwent fertility-sparing surgery from January 2005 to December 2018. Fertility outcome following treatment was determined. Survival and recurrence rate was analyzed between those who had and did not have pregnancy after surgery. Results: A total of 34 out of 661 (5.14%) new cases of ovarian cancer who underwent fertility-sparing surgery were analyzed, with a mean age of 23.71 ± 5.57 years (range: 12-36 years old), with the most common complaints of increasing abdominal girth (11/34, 32.35%) or palpable abdominal mass (11/34, 32.35%). Successful pregnancy was seen in 9 cases (26.47%), with 2 of them currently pregnant. Overall recurrence and survival rates were 14.71% and 91.18%, respectively. There was no statistically significant difference in the survival rate (88.89% vs 92%, p-value 0.7778) and rate of recurrence (22.22% and 12%, p-value 0.4578) between those who got pregnant after fertility-sparing surgery for early stage ovarian cancer, FIGO Stage IA and IC, compared to those who did not get pregnant. Conclusions Fertility-sparing surgery can be effectively offered to young patients with early stage ovarian cancer, to preserve reproductive function, with 26.47% successful pregnancy rate. Pregnancy had no significant effect on recurrence and survival among FIGO stage IA and IC ovarian cancer who underwent fertility-sparing surgery by unilateral salpingooophorectomy.
Fertility ; Health Services ; Ovarian Neoplasms

Harlequin fetus is rare and is the most severe form of congenital ichthyosis, inherited as autosomal recessive trait with an incidence of about 1 in 300,000 births. It is characterized by hyperkeratosis and desquamation of the epidermis which begins prenatally. The skin barrier is severely compromised, leading to excessive water loss, electrolyte imbalance, temperature dysregulation and an increased risk of life threatening infection. In our institution, we report a case of a pregnant woman with a previously born child affected with Harlequin Ichthyosis. For this second pregnancy, they were expecting to have a normal baby since the congenital sonographic scan done prenatally was unremarkable. However, the mother delivered at 29-30 weeks age of gestation with the fetus showing signs of harlequin ichthyosis. The child was a 1200 gram female neonate born prematurely by partial breech extraction. Clinical manifestations of harlequin ichthyosis were present at birth. Furthermore, the fetus suffered from respiratory distress few hours after delivery and died few days after birth. Prenatal diagnosis of HI is made with the use of ultrasound guided fetal skin biopsy, imaging technique with 20 and 30 real time sonography as well as genetic mutational analysis. Prenatal genetic counseling is very essential in her case because of the serious implications to consider for her offspring. The complex management of our patient can be best achieved by a multidisciplinary approach characterized by strong communication, both among the medical team and with the family.

Human ; Adult ; Harlequin Type Ichthyosis ; Ichthyosis, Lamellar ; Genetic Counseling ; Temperature ; Ichthyosiform Erythroderma, Congenital ; Parturition ; Prenatal Diagnosis ; Fetus ; Epidermis ; Electrolytes ; Biopsy

Objective: This study was designed to determine the efficacy of combined metronidazole and lactobacillus tablet in the treatment of bacterial vaginosis among pregnant women. Methodology: Fifty pregnant patients with bacterial vaginosis diagnosed by Nugent Criteria where included and randomized into group A, metronidazole and placebo and group B, metronidazole and lactobacillus tablet. The study utilized a block randomization where the sequence of the treatment assignment was randomly selected based on a set of random numbers generated. Group A received metronidazole 500 mg tab BID and placebo tablet once a day for 7 days. Group B received metronidazole 500 mg BID and lactobacillus tablet (50 million unit of lactobacillus strain per tablet) once a day for 7 days. Gram stain of vaginal discharge was done one week after the treatment, and then repeated every two weeks until delivery in both arms. Maternal and fetal complications such as premature rupture of membranes, preterm labor, chorioamnionitis were recorded. If therapy failed, patients were retreated with clindamycin 300 mg BID for one week. Adverse reactions to the drug were likewise recorded. Result: The mean Nugent score reduction in the metronidazoie and lactobacillus group was significantly larger than the mean decrease in the metronidazole and placebo groups (p-value=0.019). The result was higher after two weeks of treatment. (p-value=0.012 < 0.019).There is no significant difference in pregnancy and fetal outcome between the two groups. The metronidazole and placebo groups experienced recurrence of bacterial vaginosis of 24 percent while no patient in the metronidazole and lactobacillus groups experienced recurrence (p-value=0.022) after 4 weeks. Conclusion: Based on the findings from this study, Metronidazole combined with lactobacillus is a better treatment for bacterial vaginosis than metronidazole alone. (Author)
Lactobacillus ; Women ; Metronidazole ; Obstetric Labor, Premature ; Bacterial Infections ; Vaginitis ; Pregnant Women ; Vaginosis Bacterial

The authors investigated the effects of acupressure on intraocular pressure (IOP) in normal individuals in an uncontrolled trial.The IOP at 30, 60, and 90 minutes post-intervention was compared to that of baseline in 28 eyes of 14 normal individuals.Similarly, the IOP changes on the right and left eye were recorded after applying acupressure on the left foot only.The mean difference in IOP at 30, 60, 90 minutes after acupressure was 1.60, 3.16, 2.79, respectively, which was statistically significant at 60 and 90 minutes only (p=<0.01).The greatest decrease of IOP post acupressure was recorded at 60 minutes.The right eye showed a significantly greater decrease than the left at 60 and 90 minutes with a mean value of 2.58 and 1.98, respectively.
Human ; ACUPRESSURE ; ALTERNATIVE MEDICINE ; GLAUCOMA ; REFLEXOLOGY