1.Microscopic Polyangiitis in a Nonagenarian: Diagnostic and Therapeutic Challenges in Geriatric Vasculitis
Leila C. TOU ; Colleen DOYLE ; Gregory PAYNE ; Robert BUNTYN ; James LAMB
Annals of Geriatric Medicine and Research 2026;30(1):137-141
Microscopic polyangiitis (MPA) is a rare antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis that poses unique diagnostic and therapeutic challenges in seniors. We describe a 90-year-old female with diabetes, hypertension and heart failure who presented with anasarca and rapid renal failure. Evaluation revealed myeloperoxidase-ANCA positivity, and renal biopsy confirmed pauci-immune crescentic glomerulonephritis. Her course was complicated by anemia and deep vein thrombosis. She was managed with high-dose corticosteroids, rituximab, and supportive hemodialysis, achieving improvement in renal function. This case highlights how comorbidities may obscure recognition of vasculitis and how assessment of frailty and baseline function are essential in weighing risks of immunosuppression in older adults. Clinicians should maintain vigilance for ANCA-associated vasculitis in older adults with unexplained renal decline and tailor therapy to balance disease control with vulnerability to treatment toxicity.
2.Image-Guided Bilateral Transpedicular Basivertebral Nerve Ablation in Vertebrogenic Pain: Early Experience With Expanded Indications
Luke C. SMITH ; William Roger PETERS ; James Thomas Ernest SMITH ; Mario Giuseppe ZOTTI ; Craig BUCHAN ; Robert WRIGHT
Journal of Minimally Invasive Spine Surgery and Technique 2026;11(Suppl 1):S84-S93
Objective:
This study presents an early multicentre experience with an adapted basivertebral nerve ablation (BVNA) technique using bilateral transpedicular access, evaluating its safety, efficacy, and potential for expanded indications.
Methods:
Participants were recruited from 2 Gold Coast centres based on the presence of chronic, sharp midline axial lower back pain and evidence of type 1 or type 2 Modic changes on imaging. The radiofrequency ablation procedure was performed via transpedicular access under computed tomographic guidance. Satisfaction outcomes were assessed at 2 months using a visual analogue scale and Likert scales. Statistical analyses compared outcomes according to sex and pain indications.
Results:
Forty patients were included in the study, of whom 33 underwent BVNA for Modic type 1 and type 2 vertebrogenic pain, and 8 underwent the procedure for expanded indications, with no complications reported. Among those treated for expanded indications, 2 had vertebrogenic endplate changes adjacent to a prior fusion, 2 had persistent pain following subacute osteoporotic fractures, and one each presented with a haemangioma, inflammatory endplate osteitis associated with spondyloarthropathy, and a postmyeloma fracture. Overall, 75% of participants reported being satisfied or very satisfied with the treatment of their painful condition. All patients treated for expanded indications expressed satisfaction or high satisfaction, with visual analogue score reductions ranging from 30% to 100%.
Conclusion
Early experience with BVNA using a bilateral transpedicular access technique suggests that it is a safe and effective procedure. It may also be applicable in selected cases involving expanded indications, particularly where persistent back pain remains refractory to or unsuitable for other therapeutic options.
3.Influence of lateralized versus medialized reverse shoulder arthroplasty design on external and internal rotation: a systematic review and meta-analysis
Kevin A. HAO ; Robert J. CUETO ; Christel GHARBY ; David FREEMAN ; Joseph J. KING ; Thomas W. WRIGHT ; Diana ALMADER-DOUGLAS ; Bradley S. SCHOCH ; Jean-David WERTHEL
Clinics in Shoulder and Elbow 2024;27(1):59-71
Restoration of external (ER) and internal rotation (IR) after Grammont-style reverse shoulder arthroplasty (RSA) is often unreliable. The purpose of this systematic review was to evaluate the influence of RSA medio-lateral offset and subscapularis repair on axial rotation after RSA. Methods: We conducted a systematic review of studies evaluating axial rotation (ER, IR, or both) after RSA with a defined implant design. Medio-lateral implant classification was adopted from Werthel et al. Meta-analysis was conducted using a random-effects model. Results: Thirty-two studies reporting 2,233 RSAs were included (mean patient age, 72.5 years; follow-up, 43 months; 64% female). The subscapularis was repaired in 91% (n=2,032) of shoulders and did not differ based on global implant lateralization (91% for both, P=0.602). On meta-analysis, globally lateralized implants achieved greater postoperative ER (40° [36°–44°] vs. 27° [22°–32°], P<0.001) and postoperative improvement in ER (20° [15°–26°] vs. 10° [5°–15°], P<0.001). Lateralized implants with subscapularis repair or medialized implants without subscapularis repair had significantly greater postoperative ER and postoperative improvement in ER compared to globally medialized implants with subscapularis repair (P<0.001 for both). Mean postoperative IR was reported in 56% (n=18) of studies and achieved the minimum necessary IR in 51% of lateralized (n=325, 5 cohorts) versus 36% (n=177, 5 cohorts) of medialized implants. Conclusions: Lateralized RSA produces superior axial rotation compared to medialized RSA. Lateralized RSA with subscapularis repair and medialized RSA without subscapularis repair provide greater axial rotation compared to medialized RSA with subscapularis repair. Level of evidence: 2A.
4.Comparative study of the shear bond strength of various veneering materials on grade II commercially pure titanium.
Eun Young LEE ; Sul Gi JUN ; Robert F WRIGHT ; Eun Jin PARK
The Journal of Advanced Prosthodontics 2015;7(1):69-75
PURPOSE: To compare the shear bond strength of various veneering materials to grade II commercially pure titanium (CP-Ti). MATERIALS AND METHODS: Thirty specimens of CP-Ti disc with 9 mm diameter and 10 mm height were divided into three experimental groups. Each group was bonded to heat-polymerized acrylic resin (Lucitone 199), porcelain (Triceram), and indirect composite (Sinfony) with 7 mm diameter and 2 mm height. For the control group (n=10), Lucitone 199 were applied on type IV gold alloy castings. All samples were thermocycled for 5000 cycles in 5-55degrees C water. The maximum shear bond strength (MPa) was measured with a Universal Testing Machine. After the shear bond strength test, the failure mode was assessed with an optic microscope and a scanning electron microscope. Statistical analysis was carried out with a Kruskal-Wallis Test and Mann-Whitney Test. RESULTS: The mean shear bond strength and standard deviations for experimental groups were as follows: Ti-Lucitone 199 (12.11 +/- 4.44 MPa); Ti-Triceram (11.09 +/- 1.66 MPa); Ti-Sinfony (4.32 +/- 0.64 MPa). All of these experimental groups showed lower shear bond strength than the control group (16.14 +/- 1.89 MPa). However, there was no statistically significant difference between the Ti-Lucitone 199 group and the control group, and the Ti-Lucitone 199 group and the Ti-Triceram group. Most of the failure patterns in all experimental groups were adhesive failures. CONCLUSION: The shear bond strength of veneering materials such as heat-polymerized acrylic resin, porcelain, and indirect composite to CP-Ti was compatible to that of heatpolymerized acrylic resin to cast gold alloy.
Adhesives
;
Alloys
;
Dental Porcelain
;
Titanium*
;
Water
5.Ultrasound Guided Local Endovascular Coiling of an Iatrogenic Superficial Temporal Artery Pseudoaneurysm.
Christina Huang WRIGHT ; James WRIGHT ; Anish BADJATIYA ; Sunil MANJILA ; Steven REED ; Robert GEERTMAN
Journal of Cerebrovascular and Endovascular Neurosurgery 2015;17(4):313-317
Pseudoaneurysms of the superficial temporal artery are rare and may be treated by manual compression, surgical intervention, coil embolization, or percutaneous thrombin injection. We present a novel technique of local ultrasound guided low-profile coil embolization of the superficial temporal artery with both satisfactory cosmetic and surgical results.
Aneurysm, False*
;
Embolization, Therapeutic
;
Temporal Arteries*
;
Thrombin
;
Ultrasonography*
6.Prosthetic rehabilitation in patient with soft palatal defect.
Myung Woo CHANG ; Jong jin KIM ; John D PIRO ; Robert F WRIGHT
The Journal of Korean Academy of Prosthodontics 1999;37(1):134-138
No abstract available.
Humans
;
Rehabilitation*

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