The pandemic of the COVID-19 accelerated the research and developing process of nucle-ic acid vaccines worldwide.Biopharmaceutical companies represented by Pfizer BioNTech and Mod-erna of the United States completed the marketing of the COVID-19 mRNA vaccine at an aston-ishing speed.In a short time,COVID-19 nucleic acid vaccine from development to commercial pro-duction,and then to the rapid expansion of the industry,giving researchers great shock and inspira-tion.Can we utilize advanced technology platforms and develop veterinary nucleic acid vaccines un-der the concept of One Health to ensure the common health of animals and humans.This article summarizes the research progress of nucleic acid vaccines in companion animals and foodborne ani-mal diseases in recent years,and puts forward prospects for the application of nucleic acid vac-cines,especially mRNA vaccines.

The pandemic of the COVID-19 accelerated the research and developing process of nucle-ic acid vaccines worldwide.Biopharmaceutical companies represented by Pfizer BioNTech and Mod-erna of the United States completed the marketing of the COVID-19 mRNA vaccine at an aston-ishing speed.In a short time,COVID-19 nucleic acid vaccine from development to commercial pro-duction,and then to the rapid expansion of the industry,giving researchers great shock and inspira-tion.Can we utilize advanced technology platforms and develop veterinary nucleic acid vaccines un-der the concept of One Health to ensure the common health of animals and humans.This article summarizes the research progress of nucleic acid vaccines in companion animals and foodborne ani-mal diseases in recent years,and puts forward prospects for the application of nucleic acid vac-cines,especially mRNA vaccines.

Objective To explore the effect of irbesartan on cardiac endothelial-mesenchymal transition (EndMT) in diabetic rats.Methods The model of diabetic rat was induced by intraperitoneal injection with streptozotocin (STZ,35 mg/kg) in spontaneous hypertensive rats (SHR).Diabetic rats were divided into diabetic group and the Irbesartan treated group.The pathological changes were investigated by fluorescence microscope and electron microscope.The EndMT was studied in human aortic endothelial cells (HAEC) exposure to high glucose.The concentration of angiotensin Ⅱ in the supernatant was detected by radioimmunoassay.Immunofluorescence staining was performed to detect the co-localization of CD31 and FSP1.Results The significant myocardial fibrosis was presented in the diabetic group.Endothelial protrusions were prominent feature in myocardial microvascular of diabetic rat compared with the control group rats.Double staining of HAEC showed co-localization of CD31 and FSP1,which was decreased by the treatment of Irbesartan (P ＜ 0.05).When HAEC was exposed to high glucose,it showed some cells acquired spindle-shaped morphology and lost CD31 staining,and FSP1 and α-SMA protein expression levels were markedly upregulated,which attenuated by the treatment of Irbesartan.Conclusion Irbesartan might prevent diabetes from myocardial fibrosis via inhibition of EndMT in diabetic rats.