1.Research progress on the intervention of energy metabolism disorders in chronic heart failure by active ingredients of traditional Chinese medicine through regulating circadian rhythms
Ruiqi GUO ; Sutong WANG ; Zhaohui LYU ; Yan LI ; Renwei GUAN ; Xiao LI
China Pharmacy 2026;37(5):670-675
The onset and progression of chronic heart failure (CHF) are closely associated with myocardial energy metabolism disorders, and this pathological process significantly affects patient prognosis. Traditional Chinese medicine (TCM), grounded in time-based medical theories such as the correspondence between humans and nature and the theory of circadian flow of meridians (Ziwu Liuzhu), exhibits intrinsic consistency with modern circadian rhythm theory, providing a unique theoretical framework for understanding and intervening in CHF from a temporal perspective. This article systematically explores the impact of circadian rhythms on energy metabolism and the potential mechanisms by which TCM active ingredients intervene in CHF through a review of relevant literature. It is found that various TCM active ingredients, including flavonoids (such as nobiletin), alkaloids (such as berberine), and polyphenols (such as resveratrol), can improve mitochondrial function, promote fatty acid oxidation, enhance glucose uptake and utilization efficiency, maintain metabolic balance, and alleviate oxidative stress and inflammatory responses in myocardial cells by regulating the expression and rhythms of core circadian clock genes such as CLOCK, BMAL1, PER, and CRY. These actions thereby correct energy metabolism disorders and improve cardiac function. Further exploration of the interaction mechanisms between these components and the circadian rhythms holds promise for providing novel theoretical foundations and potential intervention strategies for the prevention and treatment of CHF.
2.Historical Evolution and Modern Research of Processing of Cyperi Rhizoma: A Review
Ming YU ; Xiuru ZHANG ; Cuicui ZHANG ; Weijie WANG ; Renwei GUAN ; Ruiqi GUO ; Fang WANG ; Huibin LIN
Chinese Journal of Experimental Traditional Medical Formulae 2023;29(3):223-232
Cyperi Rhizoma is a common Chinese medicine in clinical practice, which has a long history of processing. In order to sort out the process of its processing, starting with the angle of processing excipients, the historical evolution and developmental venation of Cyperi Rhizoma processing were analyzed and summarized by consulting relevant literature of ancient medical records and modern codes. After combing the ancient and modern literature, it was found that there were many processing methods of Cyperi Rhizoma, the processing methods without auxiliary materials included frying, boiling, steaming and so on, and the adding auxiliary materials included vinegar, ginger, salt, multiple excipients, etc. However, with the evolution of history, some characteristic excipients have gradually disappeared, while vinegar-processed products are mainly used in modern times. Meanwhile, processing methods of Cyperi Rhizoma are well documented in various processing standards, the phenomenon of multiple methods adopted in one place and different methods in different places exists, which lacks unified quality standards and leads to uneven quality of Cyperi Rhizoma decoction pieces, which may even affect the safety and effectiveness of its clinical medication. Based on this, the problems existing in the processing research of Cyperi Rhizoma were analyzed in this paper, and made an outlook on the inheritance of the ancient processing methods and the quality standard improvement of the decoction pieces, in order to provide important literature evidence and theoretical support for the study of processing process and mechanism of Cyperi Rhizoma.

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