1.Osteonecrosis as a serious adverse reaction of glucocorticoids
Zili LI ; Shushan SHI ; Jinwei JIANG ; Renrun WANG ; Fang LI
Adverse Drug Reactions Journal 1999;1(1):33-35
Objective:To analyse osteonecrosis induced by glucocorticoids in the clinical practice,and provide basis for early prevention,diagnosis and treatment.Methods:128 cases of osteonecrosiss were induced by glucocorticoidstreatment during the 10 years between 1986 and 1995,and the aspects of age,sex,course of diseases,primary diseases,dose of glucocorticoids,and early clinical manifestation were analysed.Results:The incidence of osteonecrosis was lower in doses normlly than in doses abnormally,and the incidence was higher in long treatment course than in short treatment course.Conclusion:Rational use of glucocorticoids and early prevention can reduce the incidence of osteonecrosis.
2.Osteonecrosis as a serious adverse reaction of glucocorticoids
Zili LI ; Shushan SHI ; Jinwei JIANG ; Renrun WANG ; Fang LI
Adverse Drug Reactions Journal 1999;1(1):33-35
Objective:To analyse osteonecrosis induced by glucocorticoids in the clinical practice,and provide basis for early prevention,diagnosis and treatment.Methods:128 cases of osteonecrosiss were induced by glucocorticoidstreatment during the 10 years between 1986 and 1995,and the aspects of age,sex,course of diseases,primary diseases,dose of glucocorticoids,and early clinical manifestation were analysed.Results:The incidence of osteonecrosis was lower in doses normlly than in doses abnormally,and the incidence was higher in long treatment course than in short treatment course.Conclusion:Rational use of glucocorticoids and early prevention can reduce the incidence of osteonecrosis.
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