Objective To explore the correlation between six characteristics of perioperative hypothermia and allogeneic red blood cell(RBC)transfusions in patients who underwent abdominal surgeries.Methods Patients who underwent abdominal surgeries at West China Hospital,Sichuan University between October 2019 and July 2021 were retrospectively enrolled.A wearable wireless temperature sensor was used to continuously monitor the core body temperature of patients throughout the perioperative period.The perioperative temperature nadir,maximum temperature loss,percentage of time with hypothermia,time-weigh ted average temperature,area under the curve(AUC)at 36 ℃,and AUC at 37 ℃ were calculated for the period from entering the operation room to 24 hours after the end of anesthesia.The restricted cubic spline(RCS)and multiple logistic regression models were used to explore the correlation between these temperature characteristics and perioperative allogeneic RBC transfusions.Results A total of 3119 patients were included in the study,with an allogeneic RBC transfusion rate of 2.8％.The RCS model showed that allogeneic RBC transfusion was associated with the perioperative temperature nadir(Poverall=0.048)and AUC at 36 ℃(Poverall=0.026)and no statistical significance was found in the nonlinear test.The association between allogeneic RBC transfusions and other temperature characteristics was not statistically significant.According to the RCS model results,cut-off points were taken to form groups based on the body temperature characteristics.Multivariate logistic regression showed that the perioperative temperature nadir＜35.5 ℃(odds ratio[OR]=2.47,95％confidence interval[CI]:1.21-5.03)and AUC at 36 ℃≥100 ℃·min(OR=2.24,95％CI:1.09-4.58)were associated with increased demand for allogeneic RBC transfusion.Conclusion Hypothermia is associated with an increased need for perioperative allogeneic RBC transfusions and has a cumulative effect over time.For patients at high risk of bleeding,attention should be paid to the prevention of perioperative hypothermia and reduction in the cumulative exposure to hypothermia,thereby reducing the need for blood transfusion.

Objective    To investigate the mid-to-long term quality of life (QOL) and influencing factors in the patients after heart valve replacement. Methods    Convenient sampling method was used to recruit 224 patients who had heart valve replacement surgery in our hospital from June 2008 to June 2017. There were 63 males and 161 females, aged 18-83 (51.49±10.60) years. General information questionnaire and MOS SF-36 scale were used to collect data. Univariate analysis and multiple linear regression analysis were used to analyze and determine the influencing factors for the QOL. Results    The total score of QOL of 224 patients was 71.78±17.60 points. All these scores of the patients were significantly lower than those of the general population of Chengdu (P<0.05) except the dimension of vitality. The QOL scores differences between sex, marital status, family income, working condition, the occurrence of anticoagulant complications and other complications were significant (P<0.05). Multivariate analysis showed that family income, working condition, the occurrence of anticoagulant complications and other complications could be included in the regression model, explaining 26.8% of total variance. Conclusion    The mid-to-long term QOL is lower in the patients after heart valve replacement. Family income, working condition, anticoagulant complications and other complications are the main influencing factors for mid-to-long term QOL for patients after heart valve replacement.

Objective To study the effects of ?2-adrenergic receptor gene Arg16Gly polymorphism on blood lipid and apolipoprotein ratio and its role in blood lipid and apolipoprotein ratio mediated by high carbohydrate/low fat (HC/LF) diet in healthy young persons.Methods Fifty-six healthy young volunteers had regular diet for 7 d followed by HC/LF diet for 6 d.Twelve-hour fasting venous blood samples were collected on days 1,8 and 14 to measure blood lipid and apolipoprotein (apo) AI and B100 levels,and to calculate ratios of TG/HDL-C,log (TG/HDL-C),TC/HDL-C,LDL-C/HDL-C and apoAI/apoB100.DNA was isolated from genome.Arg16Gly polymorphism was analyzed by PCR-RFLP.Results No significant difference was found in the baseline lipid and apolipoprotein ratio in subjects with AA genotype and G carriers before and after regular or HC/LF diet.The ratios of TG/HDL-C (P=0.017),log (TG/HDL-C) (P=0.031),and apoAI/apoB100 (P=0.006) were significantly higher,while those of TC/HDL-C (P=0.001) and LDL-C/HDL-C (P