Acute ischemic stroke (AIS) is a comprehensive syndrome characterized by neurological dysfunction, resulting from cerebral tissue ischemia and hypoxia due to impaired blood supply, which further leads to tissue softening or even necrosis. Restoring blood flow through recanalization of the occluded vessel is crucial for AIS treatment. Although more and more patients benefit from intravenous thrombolysis or endovascular therapy, some still have poor prognosis after vessel recanalization. Most studies indicate that ineffective recanalization, early neurological deterioration, and hemorrhagic transformation are the three main causes of adverse prognosis after recanalization therapy for AIS. This article systematically reviews the epidemiological characteristics, pathogenesis, and risk factors of the above three aspects based on previous studies, aiming to provide guidance for the diagnosis and treatment of adverse prognosis in AIS patients after recanalization therapy.

Acute ischemic stroke (AIS) is a comprehensive syndrome characterized by neurological dysfunction, resulting from cerebral tissue ischemia and hypoxia due to impaired blood supply, which further leads to tissue softening or even necrosis. Restoring blood flow through recanalization of the occluded vessel is crucial for AIS treatment. Although more and more patients benefit from intravenous thrombolysis or endovascular therapy, some still have poor prognosis after vessel recanalization. Most studies indicate that ineffective recanalization, early neurological deterioration, and hemorrhagic transformation are the three main causes of adverse prognosis after recanalization therapy for AIS. This article systematically reviews the epidemiological characteristics, pathogenesis, and risk factors of the above three aspects based on previous studies, aiming to provide guidance for the diagnosis and treatment of adverse prognosis in AIS patients after recanalization therapy.

Objective:To evaluate the relationship between systemic immune-inflammatory index (SII) and prognosis of acute respiratory distress syndrome (ARDS).Methods:ARDS patients from the I Medical Information Mart for Intensive CareⅢ were selected as the study objects. Patients were followed up for one year. The primary endpoint was the 30-day mortality rate, and secondary endpoints were the 90-day and one-year mortality rates. Cox proportional hazard regression analysis was used to assess SII as an independent risk factor for ARDS patients, with propensity score matching to control for confounding factors.Results:A total of 723 ARDS patients were included in this study. Patients with SII≥ 3655 had older age, lower SpO 2 levels, and higher simplified acute physiology scoreⅡ (SAPSⅡ) and sequential organ failure assessment (SOFA) scores compared to those with SII <3655. Additionally, the 30-day, 90-day, and one-year mortality rates were higher in patients with SII ≥3655. Cox proportional hazard regression analysis showed that high SII level was an independent risk factor for the prognosis of ARDS at 30 days ( HR=1.68, 95% CI: 1.19-2.36, P=0.0028), 90 days ( HR=1.46, 95% CI: 1.07-1.99, P=0.0170), and one year ( HR=1.34, 95% CI: 1.01-1.77, P=0.0425). Propensity score matching analysis further confirmed the relationship between SII and the prognosis of ARDS patients. Conclusions:SII, as a simple and easily measurable index, is an independent risk factor for the prognosis of ARDS patients.