Introduction: Recent advances in cancer therapy have enabled long-term survival even in patients with advanced disease; however, chronic postoperative pain and other long-term treatment-related adverse effects have emerged as new challenges. Here, we report a case in which spinal cord stimulation (SCS) was introduced for post-thoracotomy pain syndrome (PTPS) following thoracic malignancy surgery, successfully achieving pain relief and opioid dose reduction in a patient with established opioid dependence. Case: The patient, a 32-year-old woman, developed persistent neuropathic pain after surgery. Some pharmacologic therapies were ineffective, leading to increased opioid use and eventual dependence. Following SCS implantation, pain improved with marked improvement in activities of daily living. Conclusion: SCS represents an effective option for intractable pain such as PTPS and may contribute to improved quality of life and reduced opioid reliance in cancer survivors.