BACKGROND: Hepatocellular  carcinoma  (HCC)  is  a  primary  tumor  of  the  liver,  which  develops  in  the  setting  of  chronic  liver  disease.  In  the  Philippines,  despite  being  the  third  leading  site  of  cancer,  there  are  limited  studies  on  prognostic  factors,  treatment  outcomes  and  survival.
Objectives: This  study  aims  to  investigate  prognostic  features, treatment outcomes and survival of HCC patients in  our  institution.

METHODOLOGY: Retrospective  cohort  study  was  employed.  All  consecutive  patients  diagnosed  with  HCC  in  our  institution  from  January  2008  to  December  2014  were  included.  Demographic  data,  tumor  characteristics,  risk  factors  and  treatment  outcomes  were  retrieved  through 
review  of  medical  records.  Cox  regression  and  Kaplan-Meier  survival  analyses  were  used  to  identify  prognostic  factors  and  estimate  survival,  respectively.  Statistical  analyses  were  performed  with  STATA  v13.

RESULTS: A  total  of  346 patients were included. Mean age was  61.47+13.08  years.  55.78%  had  hepatitis  B  virus  (HBV)  infection,  65.15%  had  cirrhosis  solitary  nodule  (55.08%) 
was  the  dominant  tumor  pattern,  mostly  involving  the  right  lobe  (51.85%)  and  >3cm  (85.48%)  in  diameter.  43.5%  were  barcelona  clinic  liver  cancer  (BCLC)  stage  B  and  43.81%  had  advanced  stage  on  presentation  (BCLC  C/D).  Majority  did  not  have  portal  vein  thrombosis  (PVT)  and  distant  metastasis.  Overall  median  survival  was  13.17  months (range, < one month - 92 months). Those who had ocoregional  therapy  had  the  longest  median  survival  (30.33 months), followed by systemic chemotherapy (26.67
months)  then  surgery  (13.17  months).

CONCLUSION: Among HCC patients In our institution, chronic hepatitis  B  was  found  to  be  the  primary  risk  factor  for  its  development. Median survival was 13.17 months with longest median  survival  among  those  who  received  locoregional  treatment.  Child-Turcotte-Pugh  C  (CTP  C),  BCLC  stages  C and  D  were  independent  predictors  of  mortality.

Human ; Male ; Female ; Carcinoma, Hepatocellular ; Hepatitis B Virus ; Hepatitis B, Chronic ; Cytidine Triphosphate ; Portal Vein ; Liver Neoplasms ; Liver Cirrhosis ; Kaplan-meier Estimate ; Thrombosis