Congenital heart disease (CHD) may result from various risk factors including genetic, epigenetic, and environmental elements. The parallel and synchronous development of the placenta and fetal heart establishes a regulatory relationship known as the placenta-heart axis. Placental insufficiency may impact fetal cardiac development, while abnormal cardiac development can conversely disrupt placental structure and function. This review examines the association between placental abnormalities and CHD, providing insights into the etiology and underlying mechanisms of CHD.

Congenital heart disease (CHD) may result from various risk factors including genetic, epigenetic, and environmental elements. The parallel and synchronous development of the placenta and fetal heart establishes a regulatory relationship known as the placenta-heart axis. Placental insufficiency may impact fetal cardiac development, while abnormal cardiac development can conversely disrupt placental structure and function. This review examines the association between placental abnormalities and CHD, providing insights into the etiology and underlying mechanisms of CHD.